Early Gene Expression Profile in Mouse Brain after Exposure to Ionizing Radiation

2006 ◽  
Vol 165 (2) ◽  
pp. 142-154 ◽  
Author(s):  
Ashraf S. Mahmoud-Ahmed ◽  
Shelley Atkinson ◽  
C. Shun Wong
Keyword(s):  
Gene Expression ◽  
Ionizing Radiation ◽  
Gene Expression Profile ◽  
Mouse Brain ◽  
Expression Profile ◽  
Early Gene ◽  
Early Gene Expression

Early gene expression profile of human skin to injury using high-density cDNA microarrays

2001 ◽  
Vol 9 (5) ◽  
pp. 360-370 ◽  
Author(s):  
Jana Cole ◽  
Raymond Tsou ◽  
Ken Wallace ◽  
Nicole Gibran ◽  
Frank Isik
Keyword(s):  
Gene Expression ◽  
Human Skin ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Cdna Microarrays ◽  
High Density ◽  
Early Gene ◽  
Early Gene Expression

Gene Expression Profile of the Neonatal Female Mouse Brain After Administration of Testosterone Propionate

2015 ◽  
Vol 12 (4) ◽  
pp. 887-896 ◽  
Author(s):  
Yutaka Nakachi ◽  
Mioko Iseki ◽  
Tomotaka Yokoo ◽  
Yosuke Mizuno ◽  
Yasushi Okazaki
Keyword(s):  
Gene Expression ◽  
Gene Expression Profile ◽  
Mouse Brain ◽  
Expression Profile ◽  
Female Mouse ◽  
Testosterone Propionate

scholarly journals Gene Expression Profiling of Leiomyoma and Myometrial Smooth Muscle Cells in Response to Transforming Growth Factor-β

Endocrinology ◽  
2005 ◽  
Vol 146 (3) ◽  
pp. 1097-1118 ◽  
Author(s):  
Xiaoping Luo ◽  
Li Ding ◽  
Jingxia Xu ◽  
Nasser Chegini
Keyword(s):  
Gene Expression ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Binding Protein ◽  
Muscle Cells ◽  
Time Dependent ◽  
Early Gene ◽  
A Cell

Altered expression of the TGF-β system is recognized to play a central role in various fibrotic disorders, including leiomyoma. In this study we performed microarray analysis to characterize the gene expression profile of leiomyoma and matched myometrial smooth muscle cells (LSMC and MSMC, respectively) in response to the time-dependent action of TGF-β and, after pretreatment with TGF-β type II receptor (TGF-βRII) antisense oligomer-blocking/reducing TGF-β autocrine/paracrine actions. Unsupervised and supervised assessments of the gene expression values with a false discovery rate selected at P ≤ 0.001 identified 310 genes as differentially expressed and regulated in LSMC and MSMC in a cell- and time-dependent manner by TGF-β. Pretreatment with TGF-βRII antisense resulted in changes in the expression of many of the 310 genes regulated by TGF-β, with 54 genes displaying a response to TGF-β treatment. Comparative analysis of the gene expression profile in TGF-βRII antisense- and GnRH analog-treated cells indicated that these treatments target the expression of 222 genes in a cell-specific manner. Gene ontology assigned these genes functions as cell cycle regulators, transcription factors, signal transducers, tissue turnover, and apoptosis. We validated the expression and TGF-β time-dependent regulation of IL-11, TGF-β-induced factor, TGF-β-inducible early gene response, early growth response 3, CITED2 (cAMP response element binding protein-binding protein/p300-interacting transactivator with ED-rich tail), Nur77, Runx1, Runx2, p27, p57, growth arrest-specific 1, and G protein-coupled receptor kinase 5 in LSMC and MSMC using real-time PCR. Together, the results provide the first comprehensive assessment of the LSMC and MSMC molecular environment targeted by autocrine/paracrine action of TGF-β, highlighting potential involvement of specific genes whose products may influence the outcome of leiomyoma growth and fibrotic characteristics by regulating inflammatory response, cell growth, apoptosis, and tissue remodeling.

Differential oxidative stress gene expression profile in mouse brain after proton exposure

2010 ◽  
Vol 46 (8) ◽  
pp. 718-725 ◽  
Author(s):  
Sudhakar Baluchamy ◽  
Ye Zhang ◽  
Prabakaran Ravichandran ◽  
Vani Ramesh ◽  
Ayodotun Sodipe ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Gene Expression Profile ◽  
Mouse Brain ◽  
Expression Profile ◽  
Stress Gene

Memory processing and apamin induce immediate early gene expression in mouse brain

1993 ◽  
Vol 18 (1-2) ◽  
pp. 17-22 ◽  
Author(s):  
Catherine Heurteaux ◽  
Claude Messier ◽  
Claude Destrade ◽  
Michel Lazdunski
Keyword(s):  
Gene Expression ◽  
Mouse Brain ◽  
Immediate Early Gene ◽  
Early Gene ◽  
Immediate Early ◽  
Memory Processing ◽  
Early Gene Expression
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