Some Statistical Implications of Dose Uncertainty in Radiation Dose–Response Analyses

2006 ◽  
Vol 166 (1) ◽  
pp. 303-312 ◽  
Author(s):  
Daniel W. Schafer ◽  
Ethel S. Gilbert
Keyword(s):  
Radiation Dose ◽  
Dose Response ◽  
Dose Uncertainty

scholarly journals Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Ning Liu ◽  
Yang Peng ◽  
Xinguang Zhong ◽  
Zheng Ma ◽  
Suiping He ◽  
...  
Keyword(s):  
Radiation Dose ◽  
Ionizing Radiation ◽  
Dose Response ◽  
Low Dose ◽  
Linear Trend ◽  
Hematological Parameters ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Spline Models ◽  
Cumulative Radiation Dose

Abstract Background Numerous studies have concentrated on high-dose radiation exposed accidentally or through therapy, and few involve low-dose occupational exposure, to investigate the correlation between low-dose ionizing radiation and changing hematological parameters among medical workers. Methods Using a prospective cohort study design, we collected health examination reports and personal dose monitoring data from medical workers and used Poisson regression and restricted cubic spline models to assess the correlation between changing hematological parameters and cumulative radiation dose and determine the dose-response relationship. Results We observed that changing platelet of 1265 medical workers followed up was statistically different among the cumulative dose groups (P = 0.010). Although the linear trend tested was not statistically significant (Ptrend = 0.258), the non-linear trend tested was statistically significant (Pnon-linear = 0.007). Overall, there was a correlation between changing platelets and cumulative radiation dose (a change of βa 0.008 × 109/L during biennially after adjusting for gender, age at baseline, service at baseline, occupation, medical level, and smoking habits; 95% confidence interval [CI] = 0.003,0.014 × 109/L). Moreover, we also found positive first and then negative dose-response relationships between cumulative radiation dose and changing platelets by restricted cubic spline models, while there were negative patterns of the baseline service not less than 10 years (− 0.015 × 109/L, 95% CI = − 0.024, − 0.007 × 109/L) and radiation nurses(− 0.033 × 109/L, 95% CI = − 0.049, − 0.016 × 109/L). Conclusion We concluded that although the exposure dose was below the limit, medical workers exposed to low-dose ionizing radiation for a short period of time might have increased first and then decreased platelets, and there was a dose-response relationship between the cumulative radiation dose and platelets changing.

Lack of radiation dose response for patients with low-risk clinically localized prostate cancer: a retrospective analysis

2002 ◽  
Vol 53 (5) ◽  
pp. 1106-1110 ◽  
Author(s):  
Mark D Hurwitz ◽  
Lindsey Schnieder ◽  
Judith Manola ◽  
Clair J Beard ◽  
Irving D Kaplan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radiation Dose ◽  
Retrospective Analysis ◽  
Dose Response ◽  
Low Risk ◽  
Localized Prostate Cancer

A Bayesian Semiparametric Model for Radiation Dose-Response Estimation

Risk Analysis ◽  
2015 ◽  
Vol 36 (6) ◽  
pp. 1211-1223 ◽  
Author(s):  
Kyoji Furukawa ◽  
Munechika Misumi ◽  
John B. Cologne ◽  
Harry M. Cullings
Keyword(s):  
Radiation Dose ◽  
Dose Response ◽  
Semiparametric Model ◽  
Bayesian Semiparametric

Quantifying murine bone marrow and blood radiation dose response following 18F-FDG PET with DNA damage biomarkers

2014 ◽  
Vol 770 ◽  
pp. 29-36 ◽  
Author(s):  
Grainne Manning ◽  
Kristina Taylor ◽  
Paul Finnon ◽  
Jennifer A. Lemon ◽  
Douglas R. Boreham ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Dna Damage ◽  
Radiation Dose ◽  
Dose Response ◽  
Fdg Pet ◽  
Murine Bone Marrow ◽  
18F Fdg

scholarly journals Radiation dose-response (a Bayesian model) in the radiotherapy of the localized prostatic adenocarcinoma: the reliability of PSA slope changes as a response surrogate endpoint

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e7172
Author(s):  
Reza Ali Mohammadpour ◽  
Jamshid Yazdani- Charati ◽  
SZahra Faghani ◽  
Ahad Alizadeh ◽  
Mohammadreza Barzegartahamtan
Keyword(s):  
Radiation Dose ◽  
Dose Response ◽  
Specific Antigen ◽  
Surrogate Endpoint ◽  
Assessment System ◽  
T Stage ◽  
Kaplan Meier ◽  
Total Radiation Dose ◽  
Product Limit ◽  
The Relationship

Purpose One of the characteristics of Prostate-Specific Antigen (PSA) is PSA slope. It is the rate of diminishing PSA marker over time after radiotherapy (RT) in prostate cancer (PC) patients. The purpose of this study was to evaluate the relationship between increasing RT doses and PSA slope as a potential surrogate for PC recurrence. Patients and Methods This retrospective study was conducted on PC patients who were treated by radiotherapy in the Cancer Institute of Iran during 2007–2012. By reviewing the records of these patients, the baseline PSA measurement before treatment (iPSA), Gleason score (GS), clinical T stage (T. stage), and periodic PSA measurements after RT and the total radiation dose received were extracted for each patient separately. We used a Bayesian dose-response model, analysis of variance, Kruskal–Wallis test, Kaplan–Meier product-limit method for analysis. Probability values less 0.05 were considered statistically significant. Results Based on the D’Amico risk assessment system, 13.34% of patients were classified as “Low Risk”, 51.79% were “Intermediate Risk”, and 34.87% were “High Risk”. In terms of radiation doses, 12.31% of the patients received fewer than 50 Gy, 15.38% received 50 to 69 Gy, 61.03% received 70 Gy, and 11.28% received more than 70 Gy. The PSA values decreased after RT for all dose levels. The slope of PSA changes was negative for 176 of 195 patients. By increasing the dosage of radiation, the PSA decreased but these changes were not statistically significant (p = 0.701) and PSA slope as a surrogate end point cannot met the Prentice’s criteria for PC recurrence. Conclusion Significant changes in the dose-response relationship were not observed when the PSA slope was considered as the response criterion. Therefore, although the absolute value of the PSA decreased with increasing doses of RT, the relationship between PSA slope changes and increasing doses was not clear and cannot be used as a reliable response surrogate endpoint.

Radiation dose response of normal brain

1988 ◽  
Vol 14 (1) ◽  
pp. 63-70 ◽  
Author(s):  
John R. Fike ◽  
Christopher E. Cann ◽  
Krzysztof Turowski ◽  
Robert J. Higgins ◽  
Albert S.L. Chan ◽  
...  
Keyword(s):  
Radiation Dose ◽  
Dose Response ◽  
Normal Brain
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