Relative Biological Effectiveness and Tolerance Dose of Fission Neutrons in Canine Skin for a Potential Combination of Neutron Capture Therapy and Fast-Neutron Therapy

2003 ◽  
Vol 160 (4) ◽  
pp. 436-442
Author(s):  
Tsuyoshi Kadosawa ◽  
Fumihito Ohashi ◽  
Ryohei Nishimura ◽  
Nobuo Sasaki ◽  
Isao Saito ◽  
...  
Keyword(s):  
Fast Neutron ◽  
Neutron Capture ◽  
Relative Biological Effectiveness ◽  
Neutron Capture Therapy ◽  
Neutron Therapy ◽  
Tolerance Dose ◽  
Biological Effectiveness ◽  
Fission Neutrons ◽  
Fast Neutron Therapy

scholarly journals Thermal neutron Relative Biological Effectiveness factors for Boron Neutron Capture Therapy from In Vitro Irradiations

2020 ◽  
Author(s):  
María Pedrosa-Rivera ◽  
Javier Praena ◽  
Ignacio Porras ◽  
Manuel Pedro Sabariego ◽  
Ulli Köster ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Thermal Neutron ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Relative Biological Effectiveness ◽  
Neutron Capture Therapy ◽  
Tumor Cell Lines ◽  
Boron Neutron Capture ◽  
Effectiveness Factors ◽  
Biological Effectiveness

The experimental determination of the relative biological effectiveness of thermal neutron factors is fundamental in Boron Neutron Capture Therapy. Present values have been obtained using mixed beams consisting of both neutrons and photons of various energies. A common weighting factor has been used for both thermal and fast neutron doses, although such an approach has been questioned. At the nuclear reactor of the Institut Laue-Langevin a pure low-energy neutron beam has been used to determine thermal neutron relative biological effectiveness factors. Different tumor cell lines, corresponding to glioblastoma, melanoma, and head and neck squamous cell carcinoma, and non-tumor cell lines (lung fibroblast and embryonic kidney) have been irradiated using an experimental arrangement designed to minimise neutron-induced secondary gamma radiation. Additionally, the cells were irradiated with photons at a medical linear accelerator, providing reference data for comparison with that from neutron irradiation. Survival and proliferation were studied after irradiation, yielding the Relative Biological Effectiveness corresponding to the damage of thermal neutrons for the different tissue types.

The Relative Biological Effectiveness of 10 B-Neutron Capture Therapy for Early Skin Reaction in the Hamster

1991 ◽  
Vol 128 (2) ◽  
pp. 186 ◽  
Author(s):  
Junichi Hiratsuka ◽  
Hiroshi Fukuda ◽  
Tooru Kobayashi ◽  
Hiroshi Karashima ◽  
Kazuo Yoshino ◽  
...  
Keyword(s):  
Skin Reaction ◽  
Neutron Capture ◽  
Relative Biological Effectiveness ◽  
Neutron Capture Therapy ◽  
Biological Effectiveness

Treatment Planning for Boron Neutron Capture Enhanced Fast Neutron Therapy

2001 ◽  
pp. 723-728 ◽  
Author(s):  
Chandrasekhar Kota ◽  
Jay Burmeister ◽  
Richard Maughan ◽  
Kenneth Levin ◽  
Paul Chuba ◽  
...  
Keyword(s):  
Fast Neutron ◽  
Treatment Planning ◽  
Neutron Capture ◽  
Neutron Therapy ◽  
Boron Neutron Capture ◽  
Fast Neutron Therapy
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