Boron Determination in Liver Tissue by Combining Quantitative Neutron Capture Radiography (QNCR) and Histological Analysis for BNCT Treatment Planning at the TRIGA Mainz

2011 ◽  
Vol 176 (3) ◽  
pp. 388-396 ◽  
Author(s):  
C. Schütz ◽  
C. Brochhausen ◽  
S. Altieri ◽  
K. Bartholomew ◽  
S. Bortolussi ◽  
...  
Keyword(s):  
Treatment Planning ◽  
Neutron Capture ◽  
Liver Tissue ◽  
Histological Analysis ◽  
Boron Determination

Quantitative bioimaging of p-boronophenylalanine in thin liver tissue sections as a tool for treatment planning in boron neutron capture therapy

2014 ◽  
Vol 407 (9) ◽  
pp. 2365-2371 ◽  
Author(s):  
Olga Reifschneider ◽  
Christian L. Schütz ◽  
Christoph Brochhausen ◽  
Gabriele Hampel ◽  
Tobias Ross ◽  
...  
Keyword(s):  
Treatment Planning ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Liver Tissue ◽  
Neutron Capture Therapy ◽  
Tissue Sections ◽  
Boron Neutron Capture

scholarly journals Evaluation of a treatment planning system developed for clinical boron neutron capture therapy and validation against an independent Monte Carlo dose calculation system

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Naonori Hu ◽  
Hiroki Tanaka ◽  
Ryo Kakino ◽  
Syuushi Yoshikawa ◽  
Mamoru Miyao ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Treatment Planning ◽  
Neutron Capture ◽  
Gamma Ray ◽  
Dose Calculation ◽  
Planning System ◽  
Treatment Planning System ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Monte Carlo Dose Calculation

AbstractBoron neutron capture therapy (BNCT) for the treatment of unresectable, locally advanced, and recurrent carcinoma of the head and neck cancer has been approved by the Japanese government for reimbursement under the national health insurance as of June 2020. A new treatment planning system for clinical BNCT has been developed by Sumitomo Heavy Industries, Ltd. (Sumitomo), NeuCure® Dose Engine. To safely implement this system for clinical use, the simulated neutron flux and gamma ray dose rate inside a water phantom was compared against experimental measurements. Furthermore, to validate and verify the new planning system, the dose distribution inside an anthropomorphic head phantom was compared against a BNCT treatment planning system SERA and an in-house developed Monte Carlo dose calculation program. The simulated results closely matched the experimental results, within 5% for the thermal neutron flux and 10% for the gamma ray dose rate. The dose distribution inside the head phantom closely matched with SERA and the in-house developed dose calculation program, within 3% for the tumour and a difference of 0.3 Gyw for the brain.

Development of a New Monte-Carlo Treatment Planning System for Boron Neutron Capture Therapy

2009 ◽  
Author(s):  
Hiroaki Kumada ◽  
Takemi Nakamura ◽  
Akira Matsumura ◽  
Koji Ono
Keyword(s):  
Monte Carlo ◽  
Treatment Planning ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Planning System ◽  
Radiotherapy Planning ◽  
Treatment Planning System ◽  
Neutron Capture Therapy ◽  
Particle Radiotherapy ◽  
Boron Neutron Capture

To improve treatment planning in boron neutron capture therapy (BNCT), a new Monte-Carlo radiotherapy planning system is under development at Japan Atomic Energy Agency (JAEA). This system (developing code: JCDS-FX) builds on fundamental technologies of JCDS (JAEA Computation Dosimetry System) which has been applied to actual BNCT trials at Japan Research Reactor No.4 (JRR-4). Basic technologies of JCDS have been taken over to JCDS-FX, and some new functions have been built into the system. One of features of the JCDS-FX is that PHITS as a multi-purpose particle Monte-Carlo transport code has been applied to particle transport calculation. Application of PHITS enables to evaluate doses for neutrons and photons as well as protons and heavy ions. Therefore, the JCDS-FX with PHITS can perform treatment planning for not only BNCT but also particle radiotherapy. To verify calculation accuracy of the JCDS-FX with PHITS, dose evaluations for neutron irradiation of a cylindrical water phantom and for an actual clinical trial conducted at JRR-4 were performed. The verification results indicated that JCDS-FX is applicable to BNCT treatment planning in practical use. Further verifications of the system are being performed to achieve practical application of the system in the future. And in addition to the BNCT, investigations for application of the system to any other particle radiotherapy like proton therapy are carried forward.

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