scholarly journals Novel Breast Cancer Risk Alleles and Interaction with Ionizing Radiation among U.S. Radiologic Technologists

2010 ◽  
Vol 173 (2) ◽  
pp. 214-224 ◽  
Author(s):  
Parveen Bhatti ◽  
Michele M. Doody ◽  
Preetha Rajaraman ◽  
Bruce H. Alexander ◽  
Meredith Yeager ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Ionizing Radiation ◽  
Radiologic Technologists ◽  
Risk Alleles

scholarly journals Breast Cancer Risk Polymorphisms and Interaction with Ionizing Radiation among U.S. Radiologic Technologists

2008 ◽  
Vol 17 (8) ◽  
pp. 2007-2011 ◽  
Author(s):  
Parveen Bhatti ◽  
Michele M. Doody ◽  
Bruce H. Alexander ◽  
Jeff Yuenger ◽  
Steven L. Simon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Ionizing Radiation ◽  
Radiologic Technologists

scholarly journals Nucleotide excision repair polymorphisms may modify ionizing radiation-related breast cancer risk in US radiologic technologists

2008 ◽  
Vol 123 (11) ◽  
pp. 2713-2716 ◽  
Author(s):  
Preetha Rajaraman ◽  
Parveen Bhatti ◽  
Michele Morin Doody ◽  
Steven L. Simon ◽  
Robert M. Weinstock ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Ionizing Radiation ◽  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Radiologic Technologists ◽  
Nucleotide Excision

scholarly journals Radiologic Technologist and Radiologist Knowledge Gaps about Breast Density Revealed by an Online Continuing Education Course

2020 ◽  
Vol 2 (4) ◽  
pp. 315-329 ◽  
Author(s):  
Robin L Seitzman ◽  
JoAnn Pushkin ◽  
Wendie A Berg
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Continuing Education ◽  
Breast Density ◽  
Cancer Risk Assessment ◽  
Knowledge Gaps ◽  
Radiologic Technologists ◽  
Breast Cancer Risk Assessment ◽  
Post Test

Abstract Objective We sought to identify provider knowledge gaps and their predictors, as revealed by a breast density continuing education course marketed to the radiology community. Methods The course, continually available online during the study period of November 2, 2016 and December 31, 2018, includes demographics collection; a monograph on breast density, breast cancer risk, and screening; and a post-test. Four post-test questions were modified during the study period, resulting in different sample sizes pre- and postmodification. Multiple logistic regression was used to identify predictors of knowledge gaps (defined as > 25% of responses incorrect). Results Of 1649 analyzable registrants, 1363 (82.7%) were radiologic technologists, 226 (13.7%) were physicians, and 60 (3.6%) were other nonphysicians; over 90% of physicians and over 90% of technologists/nonphysicians specialized in radiology. Sixteen of 49 physicians (32.7%) and 80/233 (34.3%) technologists/nonphysicians mistakenly thought the Gail model should be used to determine “high-risk” status for recommending MRI or genetic testing. Ninety-nine of 226 (43.8%) physicians and 682/1423 (47.9%) technologists/nonphysicians misunderstood the inverse relationship between increasing age and lifetime breast cancer risk. Fifty-two of 166 (31.3%) physicians and 549/1151 (47.7%) technologists/nonphysicians were unaware that MRI should be recommended for women with a family history of BRCA1/BRCA2 mutations. Tomosynthesis effectiveness was overestimated, with 18/60 (30.0%) physicians and 95/272 (34.9%) technologists/nonphysicians believing sensitivity nearly equaled MRI. Knowledge gaps were more common in technologists/nonphysicians. Conclusions Important knowledge gaps about breast density, breast cancer risk assessment, and screening exist among radiologic technologists and radiologists. Continued education efforts may improve appropriate breast cancer screening recommendations.

Investigation of Triple-Negative Breast Cancer Risk Alleles in An International African-Enriched Cohort

2020 ◽  
Author(s):  
Rachel Martini ◽  
Yalei Chen ◽  
Brittany Jenkins ◽  
Isra Elhussin ◽  
Esther Cheng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Therapeutic Potential ◽  
African Ancestry ◽  
Case Series ◽  
European Ancestry ◽  
Risk Alleles

Abstract Large-scale efforts to identify breast cancer risk alleles have historically taken place among women on European ancestry, with recent efforts to validate these alleles or identify risk alleles applicable to women of African descent. We investigated the effect of previously reported breast cancer and triple-negative breast cancer (TNBC) risk alleles in our African enriched International Center for the Study of Breast Cancer Subtypes (ICSBCS) cohort. Using case-control and nested case-series approaches, we report that the Duffy-null allele (rs2814778) is associated with TNBC risk (OR = 3.814, p = 0.001), specifically among AA individuals, after adjusting for self-indicated race and west African ancestry (OR = 3.368, p = 0.007). We have also validated the protective effect of the minor allele of the ANKLE1 missense variant rs2363956 among AA for TNBC (OR = 0.4204, p = 0.005). We have shown that differential prevalence of the protective allele may reflect a polymorphic function of ANKLE1 in TNBC breast cancer outcomes. These AA specific risk alleles present opportunities for future studies of therapeutic potential that address race-specific differences in BC and TNBC risk and disease outcome.

scholarly journals Novel breast cancer risk alleles and endometrial cancer risk

2008 ◽  
Vol 123 (12) ◽  
pp. 2961-2964 ◽  
Author(s):  
Monica McGrath ◽  
I-Min Lee ◽  
Julie Buring ◽  
David J. Hunter ◽  
Immaculata De Vivo
Keyword(s):  
Breast Cancer ◽  
Endometrial Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Endometrial Cancer Risk ◽  
Risk Alleles
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