scholarly journals Propagation Distance of the α-Particle-Induced Bystander Effect: The Role of Nuclear Traversal and Gap Junction Communication

2009 ◽  
Vol 171 (5) ◽  
pp. 513-520 ◽  
Author(s):  
Sylvain Gaillard ◽  
David Pusset ◽  
Sonia M. de Toledo ◽  
Michel Fromm ◽  
Edouard I. Azzam
Keyword(s):  
Gap Junction ◽  
Bystander Effect ◽  
Propagation Distance ◽  
Gap Junction Communication

scholarly journals Connexin31-deficient trophoblast stem cells: a model to analyze the role of gap junction communication in mouse placental development

2004 ◽  
Vol 273 (1) ◽  
pp. 63-75 ◽  
Author(s):  
Mark Kibschull ◽  
Mariam Nassiry ◽  
Caroline Dunk ◽  
Alexandra Gellhaus ◽  
Jennifer A Quinn ◽  
...  
Keyword(s):  
Stem Cells ◽  
Gap Junction ◽  
Placental Development ◽  
Trophoblast Stem Cells ◽  
Trophoblast Stem ◽  
Gap Junction Communication

scholarly journals A model for glioma cell migration on collagen and astrocytes

2007 ◽  
Vol 5 (18) ◽  
pp. 75-83 ◽  
Author(s):  
M Aubert ◽  
M Badoual ◽  
C Christov ◽  
B Grammaticos
Keyword(s):  
Cell Migration ◽  
Gap Junction ◽  
Glioma Cell ◽  
Glioma Cells ◽  
Migration Patterns ◽  
Gap Junction Communication ◽  
Experimental Findings ◽  
Glioma Cell Migration ◽  
Gap Junction Inhibition

We present a model for the migration of glioma cells on substrates of collagen and astrocytes. The model is based on a cellular automaton where the various dynamical effects are introduced through adequate evolution rules. Using our model, we investigate the role of homotype and heterotype gap junction communication and show that it is possible to reproduce the corresponding experimental migration patterns. In particular, we confirm the experimental findings that inhibition of homotype gap junctions favours migration while heterotype inhibition hinders it. Moreover, the effect of heterotype gap junction inhibition dominates that of homotype inhibition.

scholarly journals The Role of Gap Junction Communication and Oxidative Stress in the Propagation of Toxic Effects among High-Dose α-Particle-Irradiated Human Cells

2011 ◽  
Vol 175 (3) ◽  
pp. 347-357 ◽  
Author(s):  
Narongchai Autsavapromporn ◽  
Sonia M. de Toledo ◽  
John B. Little ◽  
Jean-Paul Jay-Gerin ◽  
Andrew L. Harris ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gap Junction ◽  
Human Cells ◽  
Toxic Effects ◽  
High Dose ◽  
Gap Junction Communication ◽  
And Oxidative Stress

scholarly journals Astroglial connexins and cognition: memory formation or deterioration?

2020 ◽  
Vol 40 (1) ◽  
Author(s):  
Jin-Ting He ◽  
Xiao-Yan LI ◽  
Le Yang ◽  
Xin Zhao
Keyword(s):  
Gap Junctions ◽  
Gap Junction ◽  
Connexin 43 ◽  
Memory Formation ◽  
Gap Junction Communication ◽  
Different Types ◽  
Excessive Activation ◽  
High Conductance ◽  
Junction Proteins

Abstract Connexins are the membrane proteins that form high-conductance plasma membrane channels and are the important constituents of gap junctions and hemichannels. Among different types of connexins, connexin 43 is the most widely expressed and studied gap junction proteins in astrocytes. Due to the key involvement of astrocytes in memory impairment and abundant expression of connexins in astrocytes, astroglial connexins have been projected as key therapeutic targets for Alzheimer’s disease. On the other hand, the role of connexin gap junctions and hemichannels in memory formation and consolidation has also been reported. Moreover, deletion of these proteins and loss of gap junction communication result in loss of short-term spatial memory. Accordingly, both memory formation and memory deteriorating functions of astrocytes-located connexins have been documented. Physiologically expressed connexins may be involved in the memory formation, while pathologically increased expression of connexins with consequent excessive activation of astrocytes may induce neuronal injury and cognitive decline. The present review describes the memory formation as well as memory deteriorating functions of astroglial connexins in memory disorders of different etiology with possible mechanisms.

Opposite regulation of connexin33 and connexin43 by LPS and IL-1α in spermatogenesis

2006 ◽  
Vol 290 (3) ◽  
pp. C733-C740 ◽  
Author(s):  
Celine Fiorini ◽  
Xavier Decrouy ◽  
Norah Defamie ◽  
Dominique Segretain ◽  
Georges Pointis
Keyword(s):  
Gap Junction ◽  
Sertoli Cell ◽  
Negative Regulator ◽  
Seminiferous Tubules ◽  
Mrna Levels ◽  
Dependent Manner ◽  
Cx43 Expression ◽  
Gap Junction Communication ◽  
Cx43 Mrna

The gap junction proteins, connexins (Cxs), are present in the testis, and among them, Cx43 play an essential role in spermatogenesis. In the present study, we investigated the testicular expression and regulation of another Cx, Cx33, previously described as a negative regulator of gap junction communication. Cx33 mRNA was present in testis and undetectable in heart, liver, ovary, and uterus. In the mature testis, Cx33 was specifically immunolocalized in the basal compartment of the seminiferous tubules, whereas Cx43 was present in both seminiferous tubule and interstitial compartments. During stages IX and X of spermatogenesis, characterized by Sertoli cell phagocytosis of residual bodies, Cx43 was poorly expressed within seminiferous tubules, while Cx33 signal was strong. To evaluate the role of phagocytosis in the control of Cx33 and Cx43 expression, the effect of LPS was analyzed in the Sertoli cell line 42GPA9. We show herein that phagocytosis activation by LPS concomitantly stimulated Cx33 and inhibited Cx43 mRNA levels. These effects appear to have been mediated through IL-1α, because the exposure of Sertoli cells to the IL-1 receptor antagonist partly reversed these effects. IL-1α enhanced and reduced, respectively, the levels of Cx33 and Cx43 mRNA in a time- and dose-dependent manner. These data reveal that Cx33 and Cx43 genes are controlled differently within the testis and suggest that these two Cxs may exert opposite and complementary effects on spermatogenesis.

scholarly journals Critical role of gap junction communication, calcium and nitric oxide signaling in bystander responses to focal photodynamic injury

Oncotarget ◽  
2015 ◽  
Vol 6 (12) ◽  
pp. 10161-10174 ◽  
Author(s):  
Bianca Calì ◽  
Stefano Ceolin ◽  
Federico Ceriani ◽  
Mario Bortolozzi ◽  
Andrielly H.R. Agnellini ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Gap Junction ◽  
Critical Role ◽  
Nitric Oxide Signaling ◽  
Gap Junction Communication

The role of angiotensin in electrophysiological gap junction remodeling in human atrial fibrillation

2004 ◽  
Vol 52 (S 1) ◽  
Author(s):  
S Dhein ◽  
A Boldt ◽  
J Garbade ◽  
L Polontchouk ◽  
U Wetzel ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Gap Junction ◽  
Human Atrial Fibrillation
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