Developing Gender-Specific Gene Expression Biodosimetry Using a Panel of Radiation-Responsive Genes for Determining Radiation Dose in Human Peripheral Blood

2019 ◽  
Vol 192 (4) ◽  
pp. 399 ◽  
Author(s):  
Shuang Li ◽  
Xue Lu ◽  
Jiang-Bin Feng ◽  
Mei Tian ◽  
Jun Wang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Radiation Dose ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Specific Gene ◽  
Specific Gene Expression ◽  
Gender Specific

Gender-specific gene expression in arsenic exposed mice

2006 ◽  
Vol 164 ◽  
pp. S46
Author(s):  
Erminio Marafante ◽  
Graziella Cimino-Reale ◽  
Casati Barbara ◽  
Marie Vahter
Keyword(s):  
Gene Expression ◽  
Specific Gene ◽  
Specific Gene Expression ◽  
Gender Specific

Detection of tumor specific gene expression in bone marrow and peripheral blood from patients with small cell lung carcinoma

Cancer ◽  
2003 ◽  
Vol 97 (4) ◽  
pp. 1057-1062 ◽  
Author(s):  
Masato Shingyoji ◽  
Yuichi Takiguchi ◽  
Reiko Watanabe ◽  
Kenzo Hiroshima ◽  
Ken Motoori ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bone Marrow ◽  
Lung Carcinoma ◽  
Peripheral Blood ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Specific Gene ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Specific Gene Expression

scholarly journals Mechanistic Models of Signaling Pathways Reveal the Drug Action Mechanisms behind Gender-Specific Gene Expression for Cancer Treatments

Cells ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 1579
Author(s):  
Cankut Çubuk ◽  
Fatma E. Can ◽  
María Peña-Chilet ◽  
Joaquín Dopazo
Keyword(s):  
Gene Expression ◽  
Signaling Pathways ◽  
Drug Action ◽  
Specific Gene ◽  
Mechanistic Models ◽  
Modeling Framework ◽  
Specific Gene Expression ◽  
Action Mechanisms ◽  
Gender Specific Differences ◽  
Gender Specific

Despite the existence of differences in gene expression across numerous genes between males and females having been known for a long time, these have been mostly ignored in many studies, including drug development and its therapeutic use. In fact, the consequences of such differences over the disease mechanisms or the drug action mechanisms are completely unknown. Here we applied mechanistic mathematical models of signaling activity to reveal the ultimate functional consequences that gender-specific gene expression activities have over cell functionality and fate. Moreover, we also used the mechanistic modeling framework to simulate the drug interventions and unravel how drug action mechanisms are affected by gender-specific differential gene expression. Interestingly, some cancers have many biological processes significantly affected by these gender-specific differences (e.g., bladder or head and neck carcinomas), while others (e.g., glioblastoma or rectum cancer) are almost insensitive to them. We found that many of these gender-specific differences affect cancer-specific pathways or in physiological signaling pathways, also involved in cancer origin and development. Finally, mechanistic models have the potential to be used for finding alternative therapeutic interventions on the pathways targeted by the drug, which lead to similar results compensating the downstream consequences of gender-specific differences in gene expression.

scholarly journals Gender-Specific Gene Expression in Post-Mortem Human Brain: Localization to Sex Chromosomes

2003 ◽  
Vol 29 (2) ◽  
pp. 373-384 ◽  
Author(s):  
Marquis P Vawter ◽  
Simon Evans ◽  
Prabhakara Choudary ◽  
Hiroaki Tomita ◽  
Jim Meador-Woodruff ◽  
...  
Keyword(s):  
Gene Expression ◽  
Human Brain ◽  
Sex Chromosomes ◽  
Specific Gene ◽  
Post Mortem ◽  
Specific Gene Expression ◽  
Brain Localization ◽  
Gender Specific
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