Analysis of Radiation-Induced Chromosomal Aberrations on a Cell-by-Cell Basis after Alpha-Particle Microbeam Irradiation: Experimental Data and Simulations

2018 ◽  
Vol 189 (6) ◽  
pp. 597-604 ◽  
Author(s):  
Antonella Testa ◽  
Francesca Ballarini ◽  
Ulrich Giesen ◽  
Octávia Monteiro Gil ◽  
Mario P. Carante ◽  
...  
Keyword(s):  
Experimental Data ◽  
Alpha Particle ◽  
Chromosomal Aberrations ◽  
Cell Basis ◽  
Microbeam Irradiation ◽  
A Cell ◽  
Radiation Induced

Lean Blowout Predictions of a Non-Premixed V-Gutter Stabilized Flame Using a Damkohler Number Methodology

2011 ◽  
Author(s):  
Hui-ru Wang ◽  
Jie Jin
Keyword(s):  
Experimental Data ◽  
Number Fields ◽  
Inlet Temperature ◽  
Damkohler Number ◽  
Atmosphere Pressure ◽  
Inlet Velocity ◽  
Lean Blowout ◽  
Cell Basis ◽  
Damköhler Number ◽  
A Cell

The lean blowout stability of a non-premixed, V-gutter stabilized flame was investigated using a Damkohler number methodology. The flow and chemical timescales were extracted from the reacting RANS CFD results on a cell-by-cell basis. Assessment of three representative definitions of flow and chemical timescales for Damkohler number based on different blowout mechanisms was performed. By examining the Damkohler number fields, the structure of the flame or the possibility of blowout can be estimated. The results demonstrated that a distinct transition between stable and unstable flames was observed by decreasing the fuel-air ratio or increasing the inlet velocity at atmosphere pressure and an inlet temperature of 537K. All three definitions can predict the lean blowout limit in a reasonable consistent with the available experimental data through adjusting the critical Damkohler number of each definition in the current study. The performances and physical differences of three definitions were also discussed.

Radiation-induced versus endogenous DNA damage and assays that measure parameters reflecting DNA damage on cell by cell basis: comments on the article by Pollycove and Feinendegen

2003 ◽  
Vol 22 (6) ◽  
pp. 309-313 ◽  
Author(s):  
Joseph L Roti Roti
Keyword(s):  
Dna Damage ◽  
Comet Assay ◽  
Micronucleus Assay ◽  
State Level ◽  
Dna Lesions ◽  
Cell Basis ◽  
Significant Difference ◽  
Dependent Parameter ◽  
A Cell ◽  
Radiation Induced

The article by Pollycove and Feinendegen raises important issues regarding the relative contributions of endogenous and radiation-induced DNA damage to the overall DNA damage burden following low level radiation exposures. Clearly, resolution of the issues raised in their article will have important implications regarding regulatory philosophy. Dose-limiting studies of DNA damage measured on a cell-by-cell basis was used to analyze available data in the context of the proposed model. If one proposes that significant numbers of oxidative DNA lesions are present in cells at a steady state level at any give time, then such damage will be included in the background measure of any DNA damage dependent parameter that is sensitive to these classes of DNA damage. Then the expected number of lesions per cell was compared, prior to X- or γ-ray exposure, at the dose that gives the minimum statistically significant difference from background, at the dose where the DNA damage dependent parameter is twice background (i.e., the doubling dose). The lesion frequencies predicted from the model by Pollycove and Feinendegen are reasonable for the micronucleus assay and the inhibition of DNA supercoil rewinding, but appear to be inconsistent with results from the comet assay. Possible explanations for the inconsistency between the comet assay dose) response data and the predicted levels of DNA damage predicted by the model are discussed, suggesting that the estimates of the radiation induced damage are too low and those for endogenous damage are too high. The goal in introducing these issues is not to be negative to the article but to present a basis for future discussions and more importantly future experimental work, by which the important issues raised can be resolved.

Effect of Different Input Loading Form on Structure-Born Sound Radiation

2012 ◽  
Vol 518-523 ◽  
pp. 3768-3771
Author(s):  
Zhi Yong Xie ◽  
Qi Dou Zhou ◽  
Gang Ji
Keyword(s):  
Experimental Data ◽  
Forced Vibration ◽  
Sound Radiation ◽  
Added Mass ◽  
Elastic Vibration ◽  
Simulation And Experiment ◽  
Radiation Induced ◽  
Vibration And Sound Radiation ◽  
Loading Form ◽  
Good Agreement

The exciting force’s accurate measurement of is crucial to the structure-born sound radiation. Forced vibration and sound radiation of the ribbed cylinder is examined in the anechoic room. An approach called added mass and damping method is proposed to calculate the elastic vibration and acoustic field of the cylinder. Results obtained from simulation are show to be in good agreement with the experimental data. Sound radiation induced by different input loading form is examined via simulation and experiment. And the equipollence of force and pressure acting on the base is validated.

Modeling cell response to low doses of photon irradiation: Part 2—application to radiation-induced chromosomal aberrations in human carcinoma cells

2015 ◽  
Vol 55 (1) ◽  
pp. 31-40 ◽  
Author(s):  
Micaela Cunha ◽  
Etienne Testa ◽  
Olga V. Komova ◽  
Elena A. Nasonova ◽  
Larisa A. Mel’nikova ◽  
...  
Keyword(s):  
Chromosomal Aberrations ◽  
Cell Response ◽  
Carcinoma Cells ◽  
Low Doses ◽  
Human Carcinoma ◽  
Photon Irradiation ◽  
Radiation Induced

Radiation-Induced Buoyancy-Driven Flow in Rectangular Enclosures: Experiment and Analysis

1987 ◽  
Vol 109 (2) ◽  
pp. 427-433 ◽  
Author(s):  
B. W. Webb ◽  
R. Viskanta
Keyword(s):  
Experimental Data ◽  
Temperature Field ◽  
Theoretical Model ◽  
Radiation Flux ◽  
Convective Motion ◽  
Radiative Heating ◽  
Working Fluid ◽  
Injection Technique ◽  
Flux Divergence ◽  
Radiation Induced

Experiments have been performed to study the rate of internal radiative heating on the natural convective motion in a vertical rectangular enclosure irradiated from the side. A Mach–Zehnder interferometer has been used to determine the temperature field, and a fluorescing dye injection technique was employed to illustrate the flow structure with water as the working fluid. A theoretical model is developed for predicting the absorption of thermal radiation and the subsequent buoyancy-driven flow. Predictions based on spectral calculations for the radiation flux divergence agree well with the experimental data.

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