Analysis of Gene Expression Changes in PHA-M Stimulated Lymphocytes – Unraveling PHA Activity as Prerequisite for Dicentric Chromosome Analysis

2018 ◽  
Vol 189 (6) ◽  
pp. 579 ◽  
Author(s):  
C. Beinke, ◽  
M. Port ◽  
R. Ullmann ◽  
K. Gilbertz ◽  
M. Majewski ◽  
...  
Keyword(s):  
Gene Expression ◽  
Chromosome Analysis ◽  
Dicentric Chromosome

QUICKSCAN DICENTRIC CHROMOSOME ANALYSIS FOR RADIATION BIODOSIMETRY

2010 ◽  
Vol 98 (2) ◽  
pp. 276-281 ◽  
Author(s):  
F N. Flegal ◽  
Y Devantier ◽  
J P. McNamee ◽  
R C. Wilkins
Keyword(s):  
Chromosome Analysis ◽  
Dicentric Chromosome ◽  
Radiation Biodosimetry

scholarly journals Optimization and validation of automated dicentric chromosome analysis for radiological/nuclear triage applications

2019 ◽  
Vol 847 ◽  
pp. 503087 ◽  
Author(s):  
Terri L. Ryan ◽  
Maria B. Escalona ◽  
Tammy L. Smith ◽  
Joseph Albanese ◽  
Carol J. Iddins ◽  
...  
Keyword(s):  
Chromosome Analysis ◽  
Dicentric Chromosome

Laboratory Intercomparison of the Dicentric Chromosome Analysis Assay

2013 ◽  
Vol 180 (2) ◽  
pp. 129-137 ◽  
Author(s):  
C. Beinke ◽  
S. Barnard ◽  
H. Boulay-Greene ◽  
A. De Amicis ◽  
S. De Sanctis ◽  
...  
Keyword(s):  
Chromosome Analysis ◽  
Dicentric Chromosome ◽  
Laboratory Intercomparison

Validation of QuickScan Dicentric Chromosome Analysis for High Throughput Radiation Biological Dosimetry

2012 ◽  
Vol 102 (2) ◽  
pp. 143-153 ◽  
Author(s):  
F. N. Flegal ◽  
Y. Devantier ◽  
L. Marro ◽  
R. C. Wilkins
Keyword(s):  
High Throughput ◽  
Chromosome Analysis ◽  
Dicentric Chromosome ◽  
Biological Dosimetry

Molecular and Microscopic Analysis of Altered Gene Expression in Transgenic and Gene Targeted Mice

1996 ◽  
Vol 54 ◽  
pp. 12-13
Author(s):  
W. K. Jones ◽  
J. Robbins
Keyword(s):  
Gene Expression ◽  
Pulmonary Veins ◽  
Microscopic Analysis ◽  
Mouse Tissue ◽  
Adult Heart ◽  
Heavy Chains ◽  
Altered Gene Expression ◽  
Altered Gene ◽  
Pulmonary Myocardium

Two myosin heavy chains (MyHC) are expressed in the mammalian heart and are differentially regulated during development. In the mouse, the α-MyHC is expressed constitutively in the atrium. At birth, the β-MyHC is downregulated and replaced by the α-MyHC, which is the sole cardiac MyHC isoform in the adult heart. We have employed transgenic and gene-targeting methodologies to study the regulation of cardiac MyHC gene expression and the functional and developmental consequences of altered α-MyHC expression in the mouse.We previously characterized an α-MyHC promoter capable of driving tissue-specific and developmentally correct expression of a CAT (chloramphenicol acetyltransferase) marker in the mouse. Tissue surveys detected a small amount of CAT activity in the lung (Fig. 1a). The results of in situ hybridization analyses indicated that the pattern of CAT transcript in the adult heart (Fig. 1b, top panel) is the same as that of α-MyHC (Fig. 1b, lower panel). The α-MyHC gene is expressed in a layer of cardiac muscle (pulmonary myocardium) associated with the pulmonary veins (Fig. 1c). These studies extend our understanding of α-MyHC expression and delimit a third cardiac compartment.

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