scholarly journals Global Gene Expression Response in Mouse Models of DNA Repair Deficiency after Gamma Irradiation

2018 ◽  
Vol 189 (4) ◽  
pp. 337 ◽  
Author(s):  
Nils Rudqvist ◽  
Evagelia C. Laiakis ◽  
Shanaz A. Ghandhi ◽  
Suresh Kumar ◽  
Jeffrey D. Knotts ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Repair ◽  
Gamma Irradiation ◽  
Mouse Models ◽  
Global Gene Expression ◽  
Gene Expression Response ◽  
Repair Deficiency ◽  
Dna Repair Deficiency ◽  
Expression Response

The global gene expression response of Escherichia coli to l-phenylalanine

2005 ◽  
Vol 115 (3) ◽  
pp. 221-237 ◽  
Author(s):  
T. Polen ◽  
M. Krämer ◽  
J. Bongaerts ◽  
M. Wubbolts ◽  
V.F. Wendisch
Keyword(s):  
Gene Expression ◽  
Escherichia Coli ◽  
Global Gene Expression ◽  
Gene Expression Response ◽  
Expression Response

scholarly journals Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function

2019 ◽  
Vol 116 (29) ◽  
pp. 14573-14582 ◽  
Author(s):  
Bin Gui ◽  
Fu Gui ◽  
Tomoaki Takai ◽  
Chao Feng ◽  
Xiao Bai ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Dna Damage ◽  
Dna Repair ◽  
Androgen Receptor ◽  
Damage Repair ◽  
Repair Deficiency ◽  
Selective Targeting ◽  
Dna Repair Deficiency ◽  
Parp 1

Androgen receptor (AR) is a ligand-activated transcription factor and a key driver of prostate cancer (PCa) growth and progression. Understanding the factors influencing AR-mediated gene expression provides new opportunities for therapeutic intervention. Poly(ADP-ribose) Polymerase (PARP) is a family of enzymes, which posttranslationally modify a range of proteins and regulate many different cellular processes. PARP-1 and PARP-2 are two well-characterized PARP members, whose catalytic activity is induced by DNA-strand breaks and responsible for multiple DNA damage repair pathways. PARP inhibitors are promising therapeutic agents that show synthetic lethality against many types of cancer (including PCa) with homologous recombination (HR) DNA-repair deficiency. Here, we show that, beyond DNA damage repair function, PARP-2, but not PARP-1, is a critical component in AR transcriptional machinery through interacting with the pioneer factor FOXA1 and facilitating AR recruitment to genome-wide prostate-specific enhancer regions. Analyses of PARP-2 expression at both mRNA and protein levels show significantly higher expression of PARP-2 in primary PCa tumors than in benign prostate tissues, and even more so in castration-resistant prostate cancer (CRPC) tumors. Selective targeting of PARP-2 by genetic or pharmacological means blocks interaction between PARP-2 and FOXA1, which in turn attenuates AR-mediated gene expression and inhibits AR-positive PCa growth. Next-generation antiandrogens act through inhibiting androgen synthesis (abiraterone) or blocking ligand binding (enzalutamide). Selective targeting of PARP-2, however, may provide an alternative therapeutic approach for AR inhibition by disruption of FOXA1 function, which may be beneficial to patients, irrespective of their DNA-repair deficiency status.

Differential Global Gene Expression Response Patterns of Human Endothelium Exposed to Shear Stress and Intraluminal Pressure

2005 ◽  
Vol 42 (5) ◽  
pp. 441-452 ◽  
Author(s):  
Maria Andersson ◽  
Lena Karlsson ◽  
Per-Arne Svensson ◽  
Erik Ulfhammer ◽  
Mikael Ekman ◽  
...  
Keyword(s):  
Gene Expression ◽  
Shear Stress ◽  
Global Gene Expression ◽  
Intraluminal Pressure ◽  
Response Patterns ◽  
Gene Expression Response ◽  
Expression Response ◽  
Human Endothelium

scholarly journals Arabidopsis Plastid AMOS1/EGY1 Integrates Abscisic Acid Signaling to Regulate Global Gene Expression Response to Ammonium Stress

2012 ◽  
Vol 160 (4) ◽  
pp. 2040-2051 ◽  
Author(s):  
Baohai Li ◽  
Qing Li ◽  
Liming Xiong ◽  
Herbert J. Kronzucker ◽  
Ute Krämer ◽  
...  
Keyword(s):  
Gene Expression ◽  
Abscisic Acid ◽  
Global Gene Expression ◽  
Gene Expression Response ◽  
Abscisic Acid Signaling ◽  
Ammonium Stress ◽  
Expression Response

scholarly journals Transcriptomic responses in mouse blood during the first week after in vivo gamma irradiation

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Sunirmal Paul ◽  
Norman J. Kleiman ◽  
Sally A. Amundson
Keyword(s):  
Gene Expression ◽  
Gene Ontology ◽  
Global Gene Expression ◽  
Gene Expression Response ◽  
Neutron Exposure ◽  
Expression Response ◽  
Higher Doses ◽  
Agilent Microarrays ◽  
Radiation Biodosimetry

AbstractDue to limitations of available human models for development of gene expression based radiation biodosimetry, many such studies have made use of mouse models. To provide a broad view of the gene expression response to irradiation in the mouse, we have exposed male C57BL/6 mice to 0, 1.5, 3, 6 or 10 Gy of gamma rays, sacrificing groups of the mice at 1, 2, 3, 5, or 7 days after exposure. We then profiled global gene expression in blood from individual mice using Agilent microarrays. In general, we found increasing numbers of genes differentially expressed with increasing dose, with more prolonged responses after the higher doses. Gene ontology analysis showed a similar pattern, with more biological processes enriched among the genes responding to higher doses, and at later times after exposure. Clustering the timecourse expression data using maSigPro identified four broad patterns of response, representing different gene ontology functions. The largest of these clusters included genes with initially decreased expression followed by increased expression at later times, a pattern of expression previously reported for several genes following neutron exposure. Another gene cluster showing consistent down regulation suggests genes useful for biodosimetry throughout the first week after exposure can be identified.

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