c-Myc Sustains Transformed Phenotype and Promotes Radioresistance of Embryonal Rhabdomyosarcoma Cell Lines

2016 ◽  
Vol 185 (4) ◽  
pp. 411-422 ◽  
Author(s):  
G. L. Gravina ◽  
C. Festuccia ◽  
V. M. Popov ◽  
A. Di Rocco ◽  
A. Colapietro ◽  
...  
Keyword(s):  
Cell Lines ◽  
Embryonal Rhabdomyosarcoma ◽  
Rhabdomyosarcoma Cell

scholarly journals PARP inhibitors affect growth, survival and radiation susceptibility of human alveolar and embryonal rhabdomyosarcoma cell lines

2018 ◽  
Vol 145 (1) ◽  
pp. 137-152 ◽  
Author(s):  
Simona Camero ◽  
Simona Ceccarelli ◽  
Francesca De Felice ◽  
Francesco Marampon ◽  
Olga Mannarino ◽  
...  
Keyword(s):  
Cell Lines ◽  
Parp Inhibitors ◽  
Embryonal Rhabdomyosarcoma ◽  
Rhabdomyosarcoma Cell

scholarly journals Expression of the MyoD1 muscle determination gene defines differentiation capability but not tumorigenicity of human rhabdomyosarcomas.

1989 ◽  
Vol 9 (11) ◽  
pp. 4722-4730 ◽  
Author(s):  
A L Hiti ◽  
E Bogenmann ◽  
F Gonzales ◽  
P A Jones
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Cell Types ◽  
Chain Gene ◽  
Tumor Cell Lines ◽  
Myosin Heavy Chain Gene ◽  
Mouse Muscle ◽  
Primary Explants ◽  
Rhabdomyosarcoma Cell ◽  
Multinucleated Myotubes

Several human rhabdomyosarcoma cell lines, cultured primary tumor explants, and biopsies of tumor and normal skeletal muscle tissue expressed a 2.0-kilobase transcript that hybridized to the mouse muscle determination gene MyoD1. This transcript was found in tumor cell lines and primary explants that developed multinucleated myotubes but was absent in Wilms' tumors or cell lines and primary explants that developed multinucleated myotubes but was absent in Wilms' tumors or cell lines derived from other mesenchymal tumor cell types. Expression of the human homolog of MyoD1 therefore can define a tumor as a rhabdomyosarcoma. Transfection of the mouse MyoD1 gene into the human rhabdomyosarcoma cell line RD increased the ability of the tumor cells to differentiate into multinucleated myotubes and enhanced myosin heavy-chain gene expression but did not decrease tumorigenicity in nude mice.

scholarly journals Characterization of a New Human Embryonal Rhabdomyosarcoma Cell Line, RMS-GR

1998 ◽  
Vol 89 (5) ◽  
pp. 525-532 ◽  
Author(s):  
Juan Emilio Fernández ◽  
Jose Prados ◽  
Consolación Melguizo ◽  
Nicola Arena ◽  
Fabio Malavasi ◽  
...  
Keyword(s):  
Cell Line ◽  
Embryonal Rhabdomyosarcoma ◽  
Rhabdomyosarcoma Cell Line ◽  
Rhabdomyosarcoma Cell

Testosterone-mediated activation of androgenic signalling sustains in vitro the transformed and radioresistant phenotype of rhabdomyosarcoma cell lines

2018 ◽  
Vol 42 (2) ◽  
pp. 183-197 ◽  
Author(s):  
S. Giannattasio ◽  
F. Megiorni ◽  
V. Di Nisio ◽  
A. Del Fattore ◽  
R. Fontanella ◽  
...  
Keyword(s):  
Cell Lines ◽  
Rhabdomyosarcoma Cell
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