Immune System Modifications Induced in a Mouse Model of Chronic Exposure to90Sr

2016 ◽  
Vol 185 (3) ◽  
pp. 267-284 ◽  
Author(s):  
Nicholas Synhaeve ◽  
Stefania Musilli ◽  
Johanna Stefani ◽  
Nour Nicolas ◽  
Olivia Delissen ◽  
...  
Keyword(s):  
Immune System ◽  
Mouse Model ◽  
Chronic Exposure

Polyamine supplementation in infant formula: Influence on lymphocyte populations and immune system-related gene expression in a Balb/cOlaHsd mouse model

2014 ◽  
Vol 59 ◽  
pp. 8-15 ◽  
Author(s):  
Carlos Gómez-Gallego ◽  
Rafael Frias ◽  
Gaspar Pérez-Martínez ◽  
María José Bernal ◽  
María Jesús Periago ◽  
...  
Keyword(s):  
Gene Expression ◽  
Immune System ◽  
Mouse Model ◽  
Infant Formula ◽  
Related Gene ◽  
Lymphocyte Populations

scholarly journals Chronic exposure to aluminum and melatonin through the diet: Neurobehavioral effects in a transgenic mouse model of Alzheimer disease

2014 ◽  
Vol 69 ◽  
pp. 320-329 ◽  
Author(s):  
Celeste Di Paolo ◽  
Ingrid Reverte ◽  
Maria Teresa Colomina ◽  
José L. Domingo ◽  
Mercedes Gómez
Keyword(s):  
Alzheimer Disease ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Chronic Exposure ◽  
Transgenic Mouse Model ◽  
Neurobehavioral Effects

scholarly journals P06.07 In vivo studies of immunomodulatory a-CTLA-4 antibody in a humanized mouse model

2021 ◽  
Vol 9 (Suppl 1) ◽  
pp. A22.1-A22
Author(s):  
C Reitinger ◽  
F Nimmerjahn
Keyword(s):  
Immune System ◽  
Mouse Model ◽  
Cancer Immunotherapy ◽  
Model Systems ◽  
Checkpoint Control ◽  
Human Immune System ◽  
Humanized Mouse ◽  
Humanized Mouse Model ◽  
Human Immune

BackgroundRecent findings in cancer immunotherapy have reinforced the hypothesis that the immune system is able to control most cancers. Immunomodulatory antibodies can enhance immune responses, having the potential to generate anti-cancer immunity.1–4Materials and MethodsMost current studies addressing this question are performed in murine mouse model systems or use in vitro culture systems, which do not reflect the human in vivo situation, potentially leading to results that cannot be fully translated into human cancer therapy. Therefore, it is necessary to establish a new mouse model, which allows the study of cancer immunotherapy in the context of a human immune system. We focused on the establishment of a humanized mouse model, in which different immunomodulatory antibodies can be tested in the presence of a human immune system.ResultsFirst experiments concerning the suitability to test immunomodulatory antibodies in the humanized mouse model, revealed that effects of checkpoint-control antibody a-CTLA-4 were similar to the effects seen in patients of clinical studies. To analyse the anti-tumor activities of immunomodulatory antibodies in vivo we are establishing a human melanoma-like tumor model in humanized mice.ConclusionsThis enables us to test the efficacy of immunomodulatory agonistic antibodies (such as CP-870,893) and checkpoint control antibodies (such as anti-CTLA-4) in eliminating a melanoma-like tumor. Furthermore, parameters like tumor infiltrating human cells und cytokine/chemokine production can be analysed.ReferencesSchuster M, Nechansky A, Loibner H. Cancer immunotherapy. Biotechnol J 2006;1:138–147.Mellman I, Coukos G, Dranoff G. Cancer immunotherapy comes of age. Nature rev 2011;480:480–489.Finn OJ. Immuno-oncology: understanding the function and dysfunction of the immune system in cancer. Annals of Oncology 2012;23:vii6–vii9.Langer LF, Clay TM, Morse MA. Update on anti-CTLA-4 in clinical trials. Expert Opin Biol Ther 2007;8:1245–1256.Disclosure InformationC. Reitinger: None. F. Nimmerjahn: None.

scholarly journals Mice with a humanized immune system are resilient to transplantation of human microbiota

2021 ◽  
Author(s):  
Wei Zhou ◽  
Kin-hoe Chow ◽  
Rory Geyer ◽  
Paola Peshkepija ◽  
Elizabeth Fleming ◽  
...  
Keyword(s):  
Animal Model ◽  
Immune System ◽  
Mouse Model ◽  
Fecal Microbiota Transplantation ◽  
Host Immune System ◽  
Donor Strain ◽  
Humanized Mouse ◽  
Humanized Mouse Model ◽  
Human Leukocytes ◽  
Human Specific

Human gut microbiota has co-evolved with human, and plays important roles in regulating the development and functioning of the host immune system. To study the human-specific microbiome-immunune interaction in an animal model is challenging as the animal model needs to capture both the human-specific immune functions and the human-specific microbiome composition. Here we combined two widely-used humanization procedures to generate a humanized mouse model (HMA-huCD34) with functional human leukocytes developed from engrafted huCD34+ cells and human fecal microbes introduced through fecal microbiota transplantation, and investigated how the two introduced human components interact. We found that the engrafted human leukocytes are resilient to the transplanted human microbes, while reciprocally the transplanted microbial community in the huCD34 mice was significantly different from mice without a humanized immune system. By tracking the colonization of human fecal Bacteroides strains in the mouse gut, we found that the composition of the strain population changes over time, the trajectory of which depends upon the type of mouse. On the other hand, different from Bacteroides, Akkermansia muciniphila exhibited consistent and rapid fixation of a single donor strain in all tested mice, suggesting strong purifying selection common to all mouse types. Our prospect study illustrated the complex interactions between the transplanted microbiome and different host factors, and suggested that the humanized mouse model may not faithfully reproduce the human-specific microbiome-immune interaction.

scholarly journals Mycotoxins and health risks

1986 ◽  
Vol 5 (3) ◽  
pp. 154-156
Author(s):  
P. G. Thiel
Keyword(s):  
South Africa ◽  
Immune System ◽  
Health Risks ◽  
Chronic Exposure ◽  
Epidemiological Data ◽  
Domestic Animals ◽  
Agricultural Products ◽  
Farm Animals ◽  
Fungal Contamination ◽  
Experimental Animals

Fungal contamination of agricultural products can prove to be harmful to humans and domestic animals as these fungi produce a variety of mycotoxins which can eventually occur in food. Acute intoxications with mycotoxins occur regularly in farm animals but, fortunately, are infrequently observed in humans. However, the chronic exposure of humans to mycotoxins occurs regularly. Such exposures are potentially teratogenic and carcmogenic and can suppress the immune system. It is presently impossible to establish safe levels of exposure for most mycotoxins due to scanty epidemiological data and insufficient observations on experimental animals. With respect to aflatoxin all available data point to a real health risk. Risk analysis based on epidemiological observations shows that the liver-cancer risk for individuals in South Africa is potentially increased by continued exposure to the present legally permitted level of aflatoxin in food.

P156 PSYCHOLOGICAL STRESS INDUCES ALTERATIONS IN BEHAVIOR AND THE MUCOSAL IMMUNE SYSTEM IN A SPONTANEOUS MOUSE MODEL OF ILEITIS

2019 ◽  
Vol 156 (3) ◽  
pp. S104-S105
Author(s):  
Adrian Gomez-Nguyen ◽  
Ludovica F. Buttò ◽  
Abigail R. Basson ◽  
Theresa Pizarro ◽  
Fabio Cominelli
Keyword(s):  
Immune System ◽  
Mouse Model ◽  
Psychological Stress ◽  
Mucosal Immune System

scholarly journals Metabolomics analysis of a mouse model for chronic exposure to ambient PM2.5

2019 ◽  
Vol 247 ◽  
pp. 953-963 ◽  
Author(s):  
Yanyi Xu ◽  
Wanjun Wang ◽  
Ji Zhou ◽  
Minjie Chen ◽  
Xingke Huang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Chronic Exposure ◽  
Metabolomics Analysis

scholarly journals Dietary myo-inositol chemoprevents lung carcinogenesis via boosting immune system in Kras mouse model

2019 ◽  
Vol 11 (3) ◽  
pp. 632-635
Author(s):  
Raziye Piranlioglu ◽  
Hasan Korkaya ◽  
Khaled A. Hassan
Keyword(s):  
Immune System ◽  
Mouse Model ◽  
Lung Carcinogenesis
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