scholarly journals Ionizing Radiation Sensitizes Breast Cancer Cells to Bcl-2 Inhibitor, ABT-737, through Regulating Mcl-1

2014 ◽  
Vol 182 (6) ◽  
pp. 618-625 ◽  
Author(s):  
Hao Wu ◽  
Devora S. Schiff ◽  
Yong Lin ◽  
Hanmanth J. R. Neboori ◽  
Sharad Goyal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ionizing Radiation ◽  
Cancer Cells ◽  
Breast Cancer Cells

scholarly journals Regulation of Ionizing Radiation-Induced Adhesion of Breast Cancer Cells to Fibronectin by Alpha5beta1 Integrin

2014 ◽  
Vol 181 (6) ◽  
pp. 650-658 ◽  
Author(s):  
Shin Hee Lee ◽  
Huiwen Cheng ◽  
Ye Yuan ◽  
Shiyong Wu
Keyword(s):  
Breast Cancer ◽  
Ionizing Radiation ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Radiation Induced

Metastasis of breast cancer cells to the bone, lung, and lymph nodes promotes resistance to ionizing radiation

2017 ◽  
Vol 193 (10) ◽  
pp. 848-855 ◽  
Author(s):  
Takamitsu Hara ◽  
Manabu Iwadate ◽  
Kazunoshin Tachibana ◽  
Satoshi Waguri ◽  
Seiichi Takenoshita ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ionizing Radiation ◽  
Lymph Nodes ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Resistance To Ionizing Radiation

scholarly journals MicroRNA-302 Replacement Therapy Sensitizes Breast Cancer Cells to Ionizing Radiation

2012 ◽  
Vol 30 (4) ◽  
pp. 1008-1016 ◽  
Author(s):  
Zhongxing Liang ◽  
Jeffrey Ahn ◽  
Donna Guo ◽  
John R. Votaw ◽  
Hyunsuk Shim
Keyword(s):  
Breast Cancer ◽  
Ionizing Radiation ◽  
Replacement Therapy ◽  
Cancer Cells ◽  
Breast Cancer Cells

scholarly journals Sestrin2 Modulates AMPK Subunit Expression and Its Response to Ionizing Radiation in Breast Cancer Cells

PLoS ONE ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. e32035 ◽  
Author(s):  
Toran Sanli ◽  
Katja Linher-Melville ◽  
Theodoros Tsakiridis ◽  
Gurmit Singh
Keyword(s):  
Breast Cancer ◽  
Ionizing Radiation ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Subunit Expression

DNA-PK inhibition by NU7441 sensitizes breast cancer cells to ionizing radiation and doxorubicin

2013 ◽  
Vol 143 (1) ◽  
pp. 47-55 ◽  
Author(s):  
Wojciech M. Ciszewski ◽  
Michele Tavecchio ◽  
Jarosław Dastych ◽  
Nicola J. Curtin
Keyword(s):  
Breast Cancer ◽  
Ionizing Radiation ◽  
Cancer Cells ◽  
Breast Cancer Cells

Abstract LB-212: Ionizing radiation selectively promotes invasion of ErbB2-expressing breast cancer cells via regulation of FoxM1

2012 ◽  
Author(s):  
Diane M. Kambach ◽  
Valerie Sodi ◽  
Peter I. Lelkes ◽  
Mauricio Reginato ◽  
Jane Azizkhan-Clifford
Keyword(s):  
Breast Cancer ◽  
Ionizing Radiation ◽  
Cancer Cells ◽  
Breast Cancer Cells

scholarly journals Knockdown of lncRNA HOTAIR sensitizes breast cancer cells to ionizing radiation through activating miR-218

2019 ◽  
Vol 39 (4) ◽  
Author(s):  
Xuguang Hu ◽  
Dan Ding ◽  
Jiayi Zhang ◽  
Jianguo Cui
Keyword(s):  
Breast Cancer ◽  
Dna Damage ◽  
Ionizing Radiation ◽  
Cancer Cells ◽  
Cancer Progression ◽  
Breast Cancer Cells ◽  
Cancer Metastasis ◽  
Control Group ◽  
Radiation Induced ◽  
Lncrna Hotair

Abstract Radiotherapy is a major therapeutic strategy for breast cancer, while cancer radioresistance remains an obstacle for the successful control of the tumor. Novel radiosensitizing targets are to be developed to overcome radioresistance. Recently, long non-coding RNAs (lncRNAs) were proved to play critical roles in cancer progression. Among all, lncRNA HOTAIR was found to participate in cancer metastasis and chemoresistance. In the present study, we aimed to investigate the radiosensitizing effects of targeting HOTAIR and the underlying mechanism. Our data showed that HOTAIR (HOX antisense intergenic RNA) was up-regulated in breast cancer cells and tissues, and the expression of HOTAIR increased following irradiation. Knockdown of HOTAIR inhibited cell survival and increased cell apoptosis in response to ionizing radiation. Moreover, compared with control group, radiation induced more DNA damage and cell cycle arrest in HOTAIR knockdown cells. Finally, we found that the radiosentizing effects of HOTAIR were related to the up-regulation of miR-218, a ceRNA of HOTAIR. In conclusion, our finding showed that HOTAIR inhibition sensitizes breast cancer cells to ionizing radiation, induced severe DNA damage and activated apoptosis pathways, suggesting a possible role of HOTAIR as a novel target for breast cancer radiosensitization.

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