Ionizing Radiation-Induced Cell Death Is Partly Caused by Increase of Mitochondrial Reactive Oxygen Species in Normal Human Fibroblast Cells

2015 ◽  
Vol 183 (4) ◽  
pp. 455 ◽  
Author(s):  
Shinko Kobashigawa ◽  
Genro Kashino ◽  
Keiji Suzuki ◽  
Shunichi Yamashita ◽  
Hiromu Mori
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Human Fibroblast ◽  
Fibroblast Cells ◽  
Oxygen Species ◽  
Normal Human Fibroblast ◽  
Mitochondrial Reactive Oxygen Species ◽  
Human Fibroblast Cells ◽  
Radiation Induced ◽  
Normal Human

G2 chromatid damage and repair kinetics in normal human fibroblast cells exposed to low- or high-LET radiation

2004 ◽  
Vol 104 (1-4) ◽  
pp. 211-215 ◽  
Author(s):  
T. Kawata ◽  
H. Ito ◽  
T. Uno ◽  
M. Saito ◽  
S. Yamamoto ◽  
...  
Keyword(s):  
Human Fibroblast ◽  
Fibroblast Cells ◽  
Normal Human Fibroblast ◽  
Human Fibroblast Cells ◽  
High Let Radiation ◽  
High Let ◽  
Normal Human

scholarly journals Delayed Induction of Telomere Instability in Normal Human Fibroblast Cells by Ionizing Radiation

2004 ◽  
Vol 45 (1) ◽  
pp. 105-110 ◽  
Author(s):  
Mitsuaki OJIMA ◽  
Hiroki HAMANO ◽  
Masatoshi SUZUKI ◽  
Keiji SUZUKI ◽  
Seiji KODAMA ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Human Fibroblast ◽  
Fibroblast Cells ◽  
Normal Human Fibroblast ◽  
Human Fibroblast Cells ◽  
Normal Human

Reactivity trends of cobalt(III) complexes towards various amino acids based on the properties of the amino acid alkyl chains

2020 ◽  
Vol 76 (7) ◽  
pp. 663-672
Author(s):  
Charmaine Arderne ◽  
Kyle Fraser Batchelor ◽  
Bhawna Uprety ◽  
Rahul Chandran ◽  
Heidi Abrahamse
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Human Fibroblast ◽  
Fibroblast Cells ◽  
Normal Human Fibroblast ◽  
Alkyl Chains ◽  
Human Fibroblast Cells ◽  
Vis Spectroscopy ◽  
Normal Human

The reactivity of the cobalt(III) complexes dichlorido[tris(2-aminoethyl)amine]cobalt(III) chloride, [CoCl2(tren)]Cl, and dichlorido(triethylenetetramine)cobalt(III) chloride, [CoCl2(trien)]Cl, towards different amino acids (L-proline, L-asparagine, L-histidine and L-aspartic acid) was explored in detail. This study presents the crystal structures of three amino acidate cobalt(III) complexes, namely, (L-prolinato-κ2 N,O)[tris(2-aminoethyl)amine-κ4 N,N′,N′′,N′′′]cobalt(III) diiodide monohydrate, [Co(C5H8NO2)(C6H18N4)]I2·H2O, I, (L-asparaginato-κ2 N,O)[tris(2-aminoethyl)amine-κ4 N,N′,N′′,N′′′]cobalt(III) chloride perchlorate, [Co(C4H7N2O3)(C6H18N4)](Cl)(ClO4), II, and (L-prolinato-κ2 N,O)(triethylenetetramine-κ4 N,N′,N′′,N′′′)cobalt(III) chloride perchlorate, [Co(C4H7N2O3)(C6H18N4)](Cl)(ClO4), V. The syntheses of the complexes were followed by characterization using UV–Vis spectroscopy of the reaction mixtures and the initial rates of reaction were obtained by calculating the slopes of absorbance versus time plots. The initial rates suggest a stronger reactivity and hence greater affinity of the cobalt(III) complexes towards basic amino acids. The biocompatibility of the complexes was also assessed by evaluating the cytotoxicity of the complexes on cultured normal human fibroblast cells (WS1) in vitro. The compounds were found to be nontoxic after 24 h of incubation at concentrations up to 25 mM.

Sign in / Sign up

Export Citation Format

Share Document