The Curative Outcome of Radioimmunotherapy in a Mouse Breast Cancer Model Relies on mTOR Signaling

2014 ◽  
Vol 182 (2) ◽  
pp. 219 ◽  
Author(s):  
Inge Verbrugge ◽  
Alessia Gasparini ◽  
Nicole M. Haynes ◽  
Jim Hagekyriakou ◽  
Mara Galli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mtor Signaling ◽  
Cancer Model ◽  
Breast Cancer Model ◽  
Mouse Breast Cancer

scholarly journals Stretching Reduces Tumor Growth in a Mouse Breast Cancer Model

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
L. Berrueta ◽  
J. Bergholz ◽  
D. Munoz ◽  
I. Muskaj ◽  
G. J. Badger ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Cancer Model ◽  
Breast Cancer Model ◽  
Mouse Breast Cancer

scholarly journals Novel Medicinal Mushroom Blend as a Promising Supplement in Integrative Oncology: A Multi-Tiered Study using 4T1 Triple-Negative Mouse Breast Cancer Model

2020 ◽  
Vol 21 (10) ◽  
pp. 3479 ◽  
Author(s):  
Elisa Roda ◽  
Fabrizio De Luca ◽  
Carmine Di Iorio ◽  
Daniela Ratto ◽  
Stella Siciliani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative ◽  
Lentinula Edodes ◽  
Metastatic Breast ◽  
Medicinal Mushroom ◽  
Cancer Model ◽  
Pulmonary Tissue ◽  
Markers Of Inflammation ◽  
Breast Cancer Model ◽  
Mouse Breast Cancer

Although medicinal mushroom extracts have been proposed as promising anti-cancer agents, their precise impacts on metastatic breast cancer are still to be clarified. For this purpose, the present study exploited the effect of a novel medicinal mushroom blend, namely Micotherapy U-care, in a 4T1 triple-negative mouse breast cancer model. Mice were orally administered with Micotherapy U-care, consisting of a mixture of Agaricus blazei, Ophiocordyceps sinensis, Ganoderma lucidum, Grifola frondosa, and Lentinula edodes. The syngeneic tumor-bearing mice were generated by injecting 4T1 cells in both supplemented and non-supplemented mice. After sacrifice 35 days later, specific endpoints and pathological outcomes of the murine pulmonary tissue were evaluated. (i) Histopathological and ultrastructural analysis and (ii) immunohistochemical assessment of TGF-ß1, IL-6 and NOS2, COX2, SOD1 as markers of inflammation and oxidative stress were performed. The QoL was comparatively evaluated. Micotherapy U-care supplementation, starting before 4T1 injection and lasting until the end of the experiment, dramatically reduced the pulmonary metastases density, also triggering a decrease of fibrotic response, and reducing IL-6, NOS, and COX2 expression. SOD1 and TGF-ß1 results were also discussed. These findings support the valuable potential of Micotherapy U-care as adjuvant therapy in the critical management of triple-negative breast cancer.

scholarly journals Author Correction: Stretching Reduces Tumor Growth in a Mouse Breast Cancer Model

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
L. Berrueta ◽  
J. Bergholz ◽  
D. Munoz ◽  
I. Muskaj ◽  
G. J. Badger ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Cancer Model ◽  
Breast Cancer Model ◽  
Mouse Breast Cancer

Radiation and Gold Nanoparticle Immunomodulation in MDA MB 231 Mouse Breast Cancer Model

2020 ◽  
Vol 108 (3) ◽  
pp. e545-e546
Author(s):  
B. Janic ◽  
R. Neff ◽  
S.L. Brown ◽  
F. Liu ◽  
G. Mao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gold Nanoparticle ◽  
Cancer Model ◽  
Breast Cancer Model ◽  
Mouse Breast Cancer

scholarly journals Systemic inflammation promotes lung metastasis via E-selectin upregulation in mouse breast cancer model

2014 ◽  
Vol 15 (6) ◽  
pp. 789-796 ◽  
Author(s):  
Man Jiang ◽  
Xiaoya Xu ◽  
Yuli Bi ◽  
Jiying Xu ◽  
Chengyong Qin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lung Metastasis ◽  
Systemic Inflammation ◽  
Cancer Model ◽  
Breast Cancer Model ◽  
Mouse Breast Cancer

scholarly journals Progression to Malignancy in the Polyoma Middle T Oncoprotein Mouse Breast Cancer Model Provides a Reliable Model for Human Diseases

2003 ◽  
Vol 163 (5) ◽  
pp. 2113-2126 ◽  
Author(s):  
Elaine Y. Lin ◽  
Joan G. Jones ◽  
Ping Li ◽  
Liyin Zhu ◽  
Kathleen D. Whitney ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Diseases ◽  
Cancer Model ◽  
Breast Cancer Model ◽  
Reliable Model ◽  
Mouse Breast Cancer

Chemokine CCL2/MCP-1 negatively regulates metastasis in a highly bone marrow-metastatic mouse breast cancer model

2009 ◽  
Vol 26 (7) ◽  
pp. 817-828 ◽  
Author(s):  
Munehisa Takahashi ◽  
Hiroshi Miyazaki ◽  
Mutsuo Furihata ◽  
Hirofumi Sakai ◽  
Takeo Konakahara ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Cancer Model ◽  
Breast Cancer Model ◽  
Mouse Breast Cancer

scholarly journals Zoledronic Acid Inhibits Visceral Metastases in the 4T1/luc Mouse Breast Cancer Model

2004 ◽  
Vol 10 (13) ◽  
pp. 4559-4567 ◽  
Author(s):  
Toru Hiraga ◽  
Paul J. Williams ◽  
Akimi Ueda ◽  
Daisuke Tamura ◽  
Toshiyuki Yoneda
Keyword(s):  
Breast Cancer ◽  
Zoledronic Acid ◽  
Cancer Model ◽  
Breast Cancer Model ◽  
Mouse Breast Cancer ◽  
Visceral Metastases
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