The Greater Lethality of UVB Radiation to Cultured Human Cells is Associated with the Specific Activation of a DNA Damage-Independent Signaling Pathway

2007 ◽  
Vol 167 (6) ◽  
pp. 655-662 ◽  
Author(s):  
Miwa Horikawa-Miura ◽  
Naoki Matsuda ◽  
Masahiro Yoshida ◽  
Yutaka Okumura ◽  
Toshio Mori ◽  
...  
Keyword(s):  
Dna Damage ◽  
Signaling Pathway ◽  
Human Cells ◽  
Uvb Radiation ◽  
Cultured Human Cells

Oxidative DNA damage and inflammatory responses in cultured human cells and in humans exposed to traffic-related particles

2014 ◽  
Vol 217 (1) ◽  
pp. 23-33 ◽  
Author(s):  
Udomratana Vattanasit ◽  
Panida Navasumrit ◽  
Man Bahadur Khadka ◽  
Jantamas Kanitwithayanun ◽  
Jeerawan Promvijit ◽  
...  
Keyword(s):  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Inflammatory Responses ◽  
Human Cells ◽  
Cultured Human Cells

DNA damage and DNA repair in cultured human cells exposed to chromate

1979 ◽  
Vol 26 (3) ◽  
pp. 267-280 ◽  
Author(s):  
R.P. Whiting ◽  
H.F. Stich ◽  
D.J. Koropatnick
Keyword(s):  
Dna Damage ◽  
Dna Repair ◽  
Human Cells ◽  
Cultured Human Cells

DNA damage and growth inhibition in cultured human cells by bleomycin congeners

Biochemistry ◽  
1985 ◽  
Vol 24 (13) ◽  
pp. 3207-3214 ◽  
Author(s):  
David E. Berry ◽  
Li Ho Chang ◽  
Sidney M. Hecht
Keyword(s):  
Dna Damage ◽  
Growth Inhibition ◽  
Human Cells ◽  
Cultured Human Cells

Alpha-Tocopherol Protects Cultured Human Cells from the Acute Lethal Cytotoxicity of Dioxin

2002 ◽  
Vol 72 (3) ◽  
pp. 147-153 ◽  
Author(s):  
Kei-Ichi Hirai ◽  
Jie-Hong Pan ◽  
Ying-Bo Shui ◽  
Eriko Simamura ◽  
Hiroki Shimada ◽  
...  
Keyword(s):  
Cell Death ◽  
Cell Damage ◽  
Smooth Endoplasmic Reticulum ◽  
Dehydroascorbic Acid ◽  
Human Cells ◽  
Alpha Tocopherol ◽  
Cervical Cancer Cells ◽  
Cultured Human Cells ◽  
Nuclear Damage ◽  
Conjunctival Epithelial Cells

The possible protection of cultured human cells from acute dioxin injury by antioxidants was investigated. The most potent dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), caused vacuolization of the smooth endoplasmic reticulum and Golgi apparatus in cultured human conjunctival epithelial cells and cervical cancer cells. Subsequent nuclear damage included a deep irregular indentation resulting in cell death. A dosage of 30–40 ng/mL TCDD induced maximal intracellular production of H2O2 at 30 minutes and led to severe cell death (0–31% survival) at two hours. A dose of 1.7 mM alpha-tocopherol or 1 mM L-dehydroascorbic acid significantly protected human cells against acute TCDD injuries (78–97% survivals), but vitamin C did not provide this protection. These results indicate that accidental exposure to fatal doses of TCDD causes cytoplasmic free radical production within the smooth endoplasmic reticular systems, resulting in severe cytotoxicity, and that vitamin E and dehydroascorbic acid can protect against TCDD-induced cell damage.

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