Growth of V79 Cells as Xenograft Tumors Promotes Multicellular Resistance but does not Increase Spontaneous or Radiation-Induced Mutant Frequency

2005 ◽  
Vol 164 (6) ◽  
pp. 733-744 ◽  
Author(s):  
J. P. Banáth ◽  
L. Sinnott ◽  
B. Larrivée ◽  
S. H. MacPhail ◽  
P. L. Olive
Keyword(s):  
V79 Cells ◽  
Radiation Induced ◽  
Multicellular Resistance ◽  
Mutant Frequency ◽  
Induced Mutant

The Effect of Dose Rate on X-Radiation-Induced Mutant Frequency and the Nature of DNA Lesions in Mouse Lymphoma L5178Y Cells

1990 ◽  
Vol 122 (3) ◽  
pp. 316 ◽  
Author(s):  
Helen H. Evans ◽  
Mark Nielsen ◽  
Jaroslav Mencl ◽  
Min-Fen Horng ◽  
Marlene Ricanati
Keyword(s):  
Dose Rate ◽  
Dna Lesions ◽  
Radiation Induced ◽  
Mutant Frequency ◽  
Induced Mutant ◽  
Mouse Lymphoma

HOST-RELATIONSHIPS OF RADIATION-INDUCED MUTANT STRAINS OF HYMENOLEPIS DIMINUTA*

2006 ◽  
Vol 113 (1) ◽  
pp. 343-359 ◽  
Author(s):  
Arthur W. Jones ◽  
J. A. Dvorak ◽  
M. M. Hossain ◽  
J. L. Huffman ◽  
C. P. Hutchins ◽  
...  
Keyword(s):  
Hymenolepis Diminuta ◽  
Mutant Strains ◽  
Radiation Induced ◽  
Host Relationships ◽  
Induced Mutant

Mutant Frequency at the Hprt Locus and in Minisatellite Sequences in Chinese Hamster V79 Cells Irradiated with Low-Energy Protons (31 keV/μm) and Ultraviolet Light (254 nm)

1997 ◽  
Vol 148 (3) ◽  
pp. 203 ◽  
Author(s):  
Silvia Ogheri ◽  
Valeria Bruna ◽  
Franco Cera ◽  
Silvia Favaretto ◽  
Roberto Cherubini ◽  
...  
Keyword(s):  
Ultraviolet Light ◽  
Chinese Hamster ◽  
Low Energy ◽  
V79 Cells ◽  
Chinese Hamster V79 Cells ◽  
Hprt Locus ◽  
Mutant Frequency

scholarly journals Recovery of a low mutant frequency after ionizing radiation-induced mutagenesis during spermatogenesis

2008 ◽  
Vol 654 (2) ◽  
pp. 150-157 ◽  
Author(s):  
Guogang Xu ◽  
Gabriel W. Intano ◽  
John R. McCarrey ◽  
Ronald B. Walter ◽  
C. Alex McMahan ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Radiation Induced ◽  
Induced Mutagenesis ◽  
Mutant Frequency

EMS-induced mutant frequency and spectrum in bone marrow of D6-2 transgenic mice

1998 ◽  
Vol 41 (3) ◽  
pp. 286-292
Author(s):  
Huaixing Li ◽  
Hua Yang ◽  
Jianxiu Li ◽  
Yiping Hu ◽  
Xiaopeng Wang ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Transgenic Mice ◽  
Mutant Frequency ◽  
Induced Mutant

Chronic UV radiation–induced RORγt+ IL-22–producing lymphoid cells are associated with mutant KC clonal expansion

2021 ◽  
Vol 118 (37) ◽  
pp. e2016963118
Author(s):  
Julia M. Lewis ◽  
Patrick F. Monico ◽  
Fatima N. Mirza ◽  
Suzanne Xu ◽  
Sara Yumeen ◽  
...  
Keyword(s):  
Uv Radiation ◽  
Clonal Expansion ◽  
Lymphoid Cells ◽  
Uv Exposure ◽  
Skin Cancer Prevention ◽  
Clone Size ◽  
Radiation Induced ◽  
Type 3 ◽  
Induced Mutant ◽  
Epidermal Langerhans Cells

Chronic ultraviolet (UV) radiation exposure is the greatest risk factor for cutaneous squamous cell carcinoma (cSCC) development, and compromised immunity accelerates this risk. Having previously identified that epidermal Langerhans cells (LC) facilitate the expansion of UV-induced mutant keratinocytes (KC), we sought to more fully elucidate the immune pathways critical to cutaneous carcinogenesis and to identify potential targets of intervention. Herein, we reveal that chronic UV induces and LC enhance a local immune shift toward RORγt+ interleukin (IL)-22/IL-17A–producing cells that occurs in the presence or absence of T cells while identifying a distinct RORγt+ Sca-1+ CD103+ ICOS+ CD2+/− CCR6+ intracellular CD3+ cutaneous innate lymphoid cell type-3 (ILC3) population (uvILC3) that is associated with UV-induced mutant KC growth. We further show that mutant KC clone size is markedly reduced in the absence of RORγt+ lymphocytes or IL-22, both observed in association with expanding KC clones, and find that topical application of a RORγ/γt inhibitor during chronic UV exposure reduces local expression of IL-22 and IL-17A while markedly limiting mutant p53 KC clonal expansion. We implicate upstream Toll-like receptor signaling in driving this immune response to chronic UV exposure, as MyD88/Trif double-deficient mice also show substantially reduced p53 island number and size. These data elucidate key immune components of chronic UV–induced cutaneous carcinogenesis that might represent targets for skin cancer prevention.

Ultrastructure of giant plastids in a radiation induced mutant of Osmunda regalis

1973 ◽  
Vol 42 (5-6) ◽  
pp. 491-501 ◽  
Author(s):  
T.D. Allen ◽  
M.V. Haigh ◽  
A. Howard
Keyword(s):  
Radiation Induced ◽  
Induced Mutant
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