scholarly journals Coloration Patterns of the Tegmina of Mahanarva Spectabilis (Hemiptera: Cercopidae): Biological, Morphological and Genetic Bases

2020 ◽  
Vol 103 (3) ◽  
Author(s):  
Ricardo Aquino Borges ◽  
Alexander Machado Auad ◽  
Marcy Das Graças Fonseca ◽  
Cristiano Amancio Vieira Borges ◽  
Ana Luisa Sousa Azevedo ◽  
...  
Keyword(s):  
Coloration Patterns ◽  
Genetic Bases

EVOLUTIONARY-GENETIC BASES FOR SYMBIOTIC ENGINEERING IN PLANTS — a mini review

2018 ◽  
Vol 53 (3) ◽  
pp. 464-474
Author(s):  
N.A. Provorov ◽  
◽  
O.P. Onishchuk ◽  
Keyword(s):  
Evolutionary Genetic ◽  
Genetic Bases

Redescription of Orthopristis ruber and Orthopristis scapularis (Haemulidae: Perciformes), with a hybridization zone off the Atlantic coast of South America

Zootaxa ◽  
2019 ◽  
Vol 4576 (1) ◽  
pp. 109 ◽  
Author(s):  
ALEXANDRE PIRES MARCENIUK ◽  
RODRIGO ANTUNES CAIRES ◽  
LEONARDO MACHADO ◽  
NAJILA NOLIE CATARINE DANTAS CERQUEIRA ◽  
RAYLA ROBERTA M. DE S. SERRA ◽  
...  
Keyword(s):  
South America ◽  
Nuclear Dna ◽  
Atlantic Coast ◽  
Morphological Characteristics ◽  
Distinct Species ◽  
Valid Species ◽  
Brazilian Coast ◽  
Northern Coast ◽  
Western Atlantic ◽  
Coloration Patterns

The genus Orthopristis includes seven valid species, three from the western Atlantic and five from eastern Pacific, while the available identification guides and taxonomic keys incorrectly recognize Orthopristis ruber as the only valid species found on the Atlantic coast of South America. Efforts to expand the inventory of fish species from the northern coast of Brazil led to the identification of two distinct species of Orthopristis from Atlantic South America, based on the analysis of coloration patterns and meristic data, as well as DNA. In the present study, the limits of Orthopristis ruber are reviewed, while Orthopristis scapularis is recognized as a valid species for the northern and northeastern coasts of South America. Based on intermediate morphological characteristics and nuclear DNA markers, a hybrid zone was identified off the state of Espírito Santo, on the eastern Brazilian coast. Additionally, considerations are made on the diversity and biogeography of the coastal marine and estuarine fishes found on the Brazilian coast. 

The receptor hypothesis and the pathogenesis of depression: Genetic bases and biological correlates

2021 ◽  
Vol 167 ◽  
pp. 105542
Author(s):  
Hui-Qin Wang ◽  
Zhen-Zhen Wang ◽  
Nai-Hong Chen
Keyword(s):  
Genetic Bases

scholarly journals Molecular and Genetic Bases of Pancreatic Cancer

2012 ◽  
Vol 13 (6) ◽  
pp. 731-743 ◽  
Author(s):  
Vanja Vaccaro ◽  
Alain Gelibter ◽  
Emilio Bria ◽  
Pierluigi Iapicca ◽  
Paola Cappello ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Genetic Bases

scholarly journals Targeted inhibition of PI3Kα/δ is synergistic with BCL-2 blockade in genetically defined subtypes of DLBCL

Blood ◽  
2019 ◽  
Vol 133 (1) ◽  
pp. 70-80 ◽  
Author(s):  
Kamil Bojarczuk ◽  
Kirsty Wienand ◽  
Jeremy A. Ryan ◽  
Linfeng Chen ◽  
Mariana Villalobos-Ortiz ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Single Agent ◽  
Xenograft Model ◽  
Myeloid Cell ◽  
B Cell Lymphoma ◽  
Cell Receptor ◽  
Synergistic Activity ◽  
Genetic Bases

Abstract Inhibition of the B-cell receptor (BCR) signaling pathway is a promising treatment strategy in multiple B-cell malignancies. However, the role of BCR blockade in diffuse large B-cell lymphoma (DLBCL) remains undefined. We recently characterized primary DLBCL subsets with distinct genetic bases for perturbed BCR/phosphoinositide 3-kinase (PI3K) signaling and dysregulated B-cell lymphoma 2 (BCL-2) expression. Herein, we explore the activity of PI3K inhibitors and BCL-2 blockade in a panel of functionally and genetically characterized DLBCL cell line models. A PI3K inhibitor with predominant α/δ activity, copanlisib, exhibited the highest cytotoxicity in all BCR-dependent DLBCLs. The proapoptotic effect of copanlisib was associated with DLBCL subtype-specific dysregulated expression of BCL-2 family members including harakiri (HRK) and its antiapoptotic partner BCL extra large (BCL-xL), BCL2 related protein A1, myeloid cell leukemia 1 (MCL-1), and BCL2 interacting mediator of cell death. Using functional BH3 profiling, we found that the cytotoxic activity of copanlisib was primarily mediated through BCL-xL and MCL-1–dependent mechanisms that might complement BCL-2 blockade. For these reasons, we evaluated single-agent activity of venetoclax in the DLBCLs and identified a subset with limited sensitivity to BCL-2 blockade despite having genetic bases of BCL-2 dysregulation. As these were largely BCR-dependent DLBCLs, we hypothesized that combined inhibition of PI3Kα/δ and BCL-2 would perturb BCR-dependent and BCL-2–mediated survival pathways. Indeed, we observed synergistic activity of copanlisib/venetoclax in BCR-dependent DLBCLs with genetic bases for BCL-2 dysregulation in vitro and confirmed these findings in a xenograft model. These results provide preclinical evidence for the rational combination of PI3Kα/δ and BCL-2 blockade in genetically defined DLBCLs.

Differential coloration patterns in the intertidal crab Neohelice (=Chasmagnathus) granulata

2010 ◽  
Vol 91 (5) ◽  
pp. 1041-1047 ◽  
Author(s):  
Agustina Méndez Casariego ◽  
Tomás Luppi ◽  
Oscar Iribarne
Keyword(s):  
Salt Marshes ◽  
Field Experiments ◽  
Spatial Segregation ◽  
Body Coloration ◽  
Body Regions ◽  
Intertidal Crab ◽  
Coloration Pattern ◽  
Chasmagnathus Granulata ◽  
Colour Changes ◽  
Coloration Patterns

Many crustaceans with spatial segregation may present differential body coloration depending on the habitat they inhabit. Since crustaceans are unable to synthesize carotenoids, individuals must acquire them from their diet, so diet changes can modify individual coloration. The burrowing crab Neohelice (=Chasmagnathus) granulata inhabits the intertidal, from the uppermost parts of salt marshes to the lowest mudflat zones with a spatial segregation of different size-classes. They are primarily deposit feeders in mud flats and herbivorous–detritivorous in the salt marsh. We analysed the effect of intermoult length on the carapace colour of N. granulata, and the changes in carapace colour with crab size and zone. Crab colour varied between unvegetated and vegetated areas. Some of these differences were in part caused by colour changes related to crab size. Larger crabs show less intensive colours, and given that they inhabit the upper part of the intertidal a differential coloration pattern occurred between zones. In field experiments intermoult duration affected crab colour and some body regions analysed showed differences between zones unrelated to size.

scholarly journals The developmental and genetic bases of apetaly in Bocconia frutescens (Chelidonieae: Papaveraceae)

EvoDevo ◽  
2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Cristina Arango-Ocampo ◽  
Favio González ◽  
Juan Fernando Alzate ◽  
Natalia Pabón-Mora
Keyword(s):  
Genetic Bases
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