Pharmacokinetics of a Single Intramuscular Injection of Long-Acting Ceftiofur Crystalline-Free Acid in Cattle Egrets (Bubulcus ibis)

2017 ◽  
Vol 31 (4) ◽  
pp. 314-318
Author(s):  
Jennifer A. Waldoch ◽  
Sherry K. Cox ◽  
Douglas L. Armstrong
Keyword(s):  
Intramuscular Injection ◽  
Free Acid ◽  
Bubulcus Ibis ◽  
Single Intramuscular Injection ◽  
Long Acting

Pharmacokinetics of long-acting ceftiofur crystalline-free acid in helmeted guineafowl (Numida meleagris) after a single intramuscular injection

2011 ◽  
Vol 72 (11) ◽  
pp. 1514-1518 ◽  
Author(s):  
Kimberlee B. Wojick ◽  
Jennifer N. Langan ◽  
Michael J. Adkesson ◽  
Sherry K. Cox ◽  
Kathryn C. Gamble
Keyword(s):  
Intramuscular Injection ◽  
Free Acid ◽  
Numida Meleagris ◽  
Single Intramuscular Injection ◽  
Long Acting

scholarly journals Comparison of Intramuscular Betamethasone and Oral Pprednisone in the Prevention of Relapse of Acute Asthma

2001 ◽  
Vol 8 (3) ◽  
pp. 147-152 ◽  
Author(s):  
John S Chan ◽  
Robert L Cowie ◽  
Gerald C Lazarenka ◽  
Cinde Little ◽  
Sandra Scott ◽  
...  
Keyword(s):  
Relapse Rate ◽  
Intramuscular Injection ◽  
Inhaled Corticosteroids ◽  
Acute Asthma ◽  
Oral Prednisone ◽  
Double Blind ◽  
Intention To Treat ◽  
Single Intramuscular Injection ◽  
Acute Exacerbations ◽  
Long Acting

OBJECTIVE: To compare the relapse rate after a single intramuscular injection of a long acting corticosteroid, betamethasone, with oral prednisone in patients discharged from the emergency department (ED) for acute exacerbations of asthma.PATIENTS AND METHODS: Patients with acute exacerbations of asthma who were suitable for discharge from the ED were enrolled in a double-blind, randomized, placebo controlled pilot study. At discharge, patients were randomly assigned to receive either intramuscular betamethasone 12 mg and placebo capsules, or a placebo intramuscular injection and prednisone 50 mg daily for seven days. At days 7 and 21, patients were contacted by telephone to determine relapse. Relapse was defined as an unscheduled visit to a physician for treatment of continuing or worsening symptoms of asthma.RESULTS: One hundred and seventy-one patients were enrolled, of whom 87 were randomly assigned to the betamethasone group and 84 to the prednisone group. Baseline char- acteristics were matched evenly between the groups, with the exception of asthma duration (15.5 versus 21.2 years, respectively) and use of inhaled corticosteroids (46% versus 64.3% respectively) (P<0.05). Using intention-to-treat analysis, the relapse rates for betamethasone and prednisone at day 7 were 14.9% (13 of 87 patients) and 25% (21 of 84 patients), respectively (P=0.1), and at day 21, the rates were 36.8% (32 of 87 patients) and 31% (26 of 84 patients), respectively (P=0.4). There were no differences in symptom score, peak flows and adverse effects between the two groups at days 7 and 21.CONCLUSIONS: A single dose of intramuscular betamethasone 12 mg was safe and as efficacious as prednisone in preventing the relapse of acute asthma. There was a trend toward a reduced relapse rate at seven days. In select ED patients discharged for acute asthma, intramuscular betamethasone may be an effective alternative to prednisone.

A CLINICAL BIOASSAY METHOD OF LONG-ACTING CORTICOTROPHIN PREPARATIONS AND ITS APPLICATION AS AN INTRAMUSCULAR CORTICOTROPHIN TEST

1964 ◽  
Vol 47 (4) ◽  
pp. 565-573
Author(s):  
H. Colldahl ◽  
E. Diczfalusy
Keyword(s):  
Intravenous Infusion ◽  
Intramuscular Injection ◽  
Block Design ◽  
Phosphate Solution ◽  
Acth Test ◽  
Asthmatic Patients ◽  
Randomized Block Design ◽  
Single Intramuscular Injection ◽  
Long Acting ◽  
Different Order

ABSTRACT The corticosteroidogenetic potency of a corticotrophin preparation – given as an intravenous infusion – was compared in asthmatic patients with that of the same preparation dissolved in an aqueous polyphloretin phosphate solution and given as a single intramuscular injection. Four-point assays with a completely randomized block design were employed, each patient being injected with each of the four doses in a different order. The results indicate that for the purposes of a clinical corticotrophin (ACTH)-test, the 8-hours' intravenous infusion of corticotrophin can suitably be replaced by a single intramuscular injection of a mixture of corticotrophin and polyphloretin phosphate. The clinical bioassay described appears also suitable for the assessment of the corticosteroidogenetic potency of various types of long-acting corticotrophin preparations.

Pharmacokinetics of a single intramuscular injection of ceftiofur crystalline-free acid in American black ducks (Anas rubripes)

2012 ◽  
Vol 73 (5) ◽  
pp. 620-627 ◽  
Author(s):  
Katharine L. Hope ◽  
Lisa A. Tell ◽  
Barbara A. Byrne ◽  
Suzan Murray ◽  
Scott E. Wetzlich ◽  
...  
Keyword(s):  
Intramuscular Injection ◽  
Free Acid ◽  
Anas Rubripes ◽  
Single Intramuscular Injection ◽  
American Black

Pharmacokinetics of a single intramuscular injection of ceftiofur crystalline-free acid in red-tailed hawks (Buteo jamaicensis)

2015 ◽  
Vol 76 (12) ◽  
pp. 1077-1084 ◽  
Author(s):  
Miranda J. Sadar ◽  
Michelle G. Hawkins ◽  
Barbara A. Byrne ◽  
Andrew N. Cartoceti ◽  
Kevin Keel ◽  
...  
Keyword(s):  
Intramuscular Injection ◽  
Free Acid ◽  
Buteo Jamaicensis ◽  
Single Intramuscular Injection
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