Osteosarcoma of the Tibiotarsus With Possible Pulmonary Metastasis in a Ring-necked Dove (Streptopelia risoria)

2014 ◽  
Vol 28 (1) ◽  
pp. 50-56 ◽  
Author(s):  
Stephanie Lamb ◽  
Drury Reavill ◽  
John Wojcieszyn ◽  
Nicholas Sitinas
Keyword(s):  
Pulmonary Metastasis ◽  
Streptopelia Risoria

Thulium cyber laser-assisted uniportal thoracoscopic resection of a pulmonary metastasis from colorectal cancer

2020 ◽  
Vol 75 (6) ◽  
Author(s):  
Filippo Lococo ◽  
Amedeo Iaffaldano ◽  
Edoardo Zanfrini ◽  
Luca Pogliani ◽  
Diomira Tabacco ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Pulmonary Metastasis ◽  
Thoracoscopic Resection

scholarly journals Platelet-derived lysophosphatidic acid mediated LPAR1 activation as a therapeutic target for osteosarcoma metastasis

Oncogene ◽  
2021 ◽  
Author(s):  
Satoshi Takagi ◽  
Yuki Sasaki ◽  
Sumie Koike ◽  
Ai Takemoto ◽  
Yosuke Seto ◽  
...  
Keyword(s):  
Platelet Activation ◽  
Pulmonary Metastasis ◽  
Lysophosphatidic Acid ◽  
Therapeutic Intervention ◽  
Molecular Mechanisms ◽  
Morphological Changes ◽  
Osteosarcoma Cells ◽  
Invasion And Metastasis ◽  
Platelet Releasate

AbstractOsteosarcoma is the most common primary malignant bone cancer, with high rates of pulmonary metastasis. Osteosarcoma patients with pulmonary metastasis have worse prognosis than those with localized disease, leading to dramatically reduced survival rates. Therefore, understanding the biological characteristics of metastatic osteosarcoma and the molecular mechanisms of invasion and metastasis of osteosarcoma cells will lead to the development of innovative therapeutic intervention for advanced osteosarcoma. Here, we identified that osteosarcoma cells commonly exhibit high platelet activation-inducing characteristics, and molecules released from activated platelets promote the invasiveness of osteosarcoma cells. Given that heat-denatured platelet releasate maintained the ability to promote osteosarcoma invasion, we focused on heat-tolerant molecules, such as lipid mediators in the platelet releasate. Osteosarcoma-induced platelet activation leads to abundant lysophosphatidic acid (LPA) release. Exposure to LPA or platelet releasate induced morphological changes and increased invasiveness of osteosarcoma cells. By analyzing publicly available transcriptome datasets and our in-house osteosarcoma patient-derived xenograft tumors, we found that LPA receptor 1 (LPAR1) is notably upregulated in osteosarcoma. LPAR1 gene KO in osteosarcoma cells abolished the platelet-mediated osteosarcoma invasion in vitro and the formation of early pulmonary metastatic foci in experimental pulmonary metastasis models. Of note, the pharmacological inhibition of LPAR1 by the orally available LPAR1 antagonist, ONO-7300243, prevented pulmonary metastasis of osteosarcoma in the mouse models. These results indicate that the LPA–LPAR1 axis is essential for the osteosarcoma invasion and metastasis, and targeting LPAR1 would be a promising therapeutic intervention for advanced osteosarcoma.

scholarly journals A Theranostic Cellulose Nanocrystal‐Based Drug Delivery System with Enhanced Retention in Pulmonary Metastasis of Melanoma

Small ◽  
2021 ◽  
pp. 2007705
Author(s):  
Surachet Imlimthan ◽  
You Cheng Khng ◽  
Outi Keinänen ◽  
Wenzhong Zhang ◽  
Anu J. Airaksinen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Pulmonary Metastasis ◽  
Cellulose Nanocrystal

scholarly journals Prometastatic secretome trafficking via exosomes initiates pancreatic cancer pulmonary metastasis

2020 ◽  
Vol 481 ◽  
pp. 63-75 ◽  
Author(s):  
Kosuke Ogawa ◽  
Qiushi Lin ◽  
Le Li ◽  
Xuewei Bai ◽  
Xuesong Chen ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Pulmonary Metastasis
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