CANINE DISTEMPER VIRUS ANTIBODY TITERS IN DOMESTIC CATS AFTER DELIVERY OF A LIVE ATTENUATED VIRUS VACCINE

2016 ◽  
Vol 47 (2) ◽  
pp. 551-557 ◽  
Author(s):  
Edward Ramsay ◽  
Ryan Sadler ◽  
Robert Rush ◽  
Tracie Seimon ◽  
Ania Tomaszewicz ◽  
...  
Keyword(s):  
Virus Vaccine ◽  
Canine Distemper Virus ◽  
Domestic Cats ◽  
Canine Distemper ◽  
Virus Antibody ◽  
Attenuated Virus ◽  
Antibody Titers

scholarly journals Vaccination against Canine Distemper Virus Infection in Infant Ferrets with and without Maternal Antibody Protection, Using Recombinant Attenuated Poxvirus Vaccines

2000 ◽  
Vol 74 (14) ◽  
pp. 6358-6367 ◽  
Author(s):  
Janet Welter ◽  
Jill Taylor ◽  
James Tartaglia ◽  
Enzo Paoletti ◽  
Charles B. Stephensen
Keyword(s):  
Canine Distemper Virus ◽  
Clinical Signs ◽  
Neutralizing Antibody ◽  
Maternal Antibody ◽  
Canine Distemper ◽  
Parenteral Immunization ◽  
Multiple Routes ◽  
Antibody Titers ◽  
Group 3 ◽  
Rabies Glycoprotein

ABSTRACT Canine distemper virus (CDV) infection of ferrets is clinically and immunologically similar to measles, making this a useful model for the human disease. The model was used to determine if parenteral or mucosal immunization of infant ferrets at 3 and 6 weeks of age with attenuated vaccinia virus (NYVAC) or canarypox virus (ALVAC) vaccine strains expressing the CDV hemagglutinin (H) and fusion (F) protein genes (NYVAC-HF and ALVAC-HF) would induce serum neutralizing antibody and protect against challenge infection at 12 weeks of age. Ferrets without maternal antibody that were vaccinated parenterally with NYVAC-HF (n = 5) or ALVAC-HF (n = 4) developed significant neutralizing titers (log10 inverse mean titer ± standard deviation of 2.30 ± 0.12 and 2.20 ± 0.34, respectively) by the day of challenge, and all survived with no clinical or virologic evidence of infection. Ferrets without maternal antibody that were vaccinated intranasally (i.n.) developed lower neutralizing titers, with NYVAC-HF producing higher titers at challenge (1.11 ± 0.57 versus 0.40 ± 0.37, P = 0.02) and a better survival rate (6/7 versus 0/5, P = 0.008) than ALVAC-HF. Ferrets with maternal antibody that were vaccinated parenterally with NYVAC-HF (n = 7) and ALVAC-HF (n = 7) developed significantly higher antibody titers (1.64 ± 0.54 and 1.28 ± 0.40, respectively) than did ferrets immunized with an attenuated CDV vaccine (0.46 ± 0.59;n = 7) or the recombinant vectors expressing rabies glycoprotein (RG) (0.19 ± 0.32; n = 8,P = 7 × 10−6). The NYVAC vaccine also protected against weight loss, and both the NYVAC and attenuated CDV vaccines protected against the development of some clinical signs of infection, although survival in each of the three vaccine groups was low (one of seven) and not significantly different from the RG controls (none of eight). Combined i.n.-parenteral immunization of ferrets with maternal antibody using NYVAC-HF (n = 9) produced higher titers (1.63 ± 0.25) than did i.n. immunization with NYVAC-HF (0.88 ± 0.36; n = 9) and ALVAC-HF (0.61 ± 0.43; n = 9, P = 3 × 10−7), and survival was also significantly better in the i.n.-parenteral group (3 of 9) than in the other HF-vaccinated animals (none of 18) or in controls immunized with RG (none of 5) (P = 0.0374). Multiple routes were not tested with the ALVAC vaccine. The results suggest that infant ferrets are less responsive to i.n. vaccination than are older ferrets and raises questions about the appropriateness of this route of immunization in infant ferrets or infants of other species.

HUMORAL RESPONSE AND PROTECTION FROM EXPERIMENTAL CHALLENGE FOLLOWING VACCINATION OF RACCOON PUPS WITH A MODIFIED-LIVE CANINE DISTEMPER VIRUS VACCINE

1999 ◽  
Vol 35 (3) ◽  
pp. 430-439 ◽  
Author(s):  
Jean A. Paré ◽  
Ian K. Barker ◽  
Graham J. Crawshaw ◽  
Scott A. McEwen ◽  
P. Susy Carman ◽  
...  
Keyword(s):  
Virus Vaccine ◽  
Canine Distemper Virus ◽  
Humoral Response ◽  
Canine Distemper ◽  
Experimental Challenge

Seroconversion of puppies to canine parvovirus and canine distemper virus: a comparison of two combination vaccines

2000 ◽  
Vol 36 (2) ◽  
pp. 137-142 ◽  
Author(s):  
MJ Coyne
Keyword(s):  
Canine Distemper Virus ◽  
Serum Antibody ◽  
Canine Parvovirus ◽  
The Other ◽  
Canine Distemper ◽  
Combination Vaccines ◽  
Antibody Titers ◽  
The Mean ◽  
To Receive ◽  
Mean Time

Sixty puppies were randomly assigned to receive one of two commercially available combination vaccines, and responses to the canine parvovirus and canine distemper virus components of the vaccines were determined by measuring serum antibody titers. The percentage of puppies that seroconverted to canine parvovirus was significantly higher and the mean time for seroconversion was significantly shorter for puppies that received one of the vaccines than for puppies that received the other vaccine. Percentages of puppies that seroconverted to canine distemper virus were not significantly different.

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