Endogenous Fibroblastic Progenitor Cells in the Adult Mouse Lung Are Highly Enriched in the Sca-1 Positive Cell Fraction

Stem Cells ◽  
2009 ◽  
Vol 27 (3) ◽  
pp. 623-633 ◽  
Author(s):  
Jonathan L. McQualter ◽  
Nathalie Brouard ◽  
Brenda Williams ◽  
Brandi N. Baird ◽  
Sunder Sims-Lucas ◽  
...  
2014 ◽  
Vol 23 (22) ◽  
pp. 2744-2757 ◽  
Author(s):  
Olga Chernaya ◽  
Vasily Shinin ◽  
Yuru Liu ◽  
Richard D. Minshall

Stem Cells ◽  
2008 ◽  
Vol 26 (4) ◽  
pp. 979-987 ◽  
Author(s):  
Mohammad G. Golmohammadi ◽  
Daniel G. Blackmore ◽  
Beatrice Large ◽  
Hassan Azari ◽  
Ebrahim Esfandiary ◽  
...  

2013 ◽  
Vol 13 (4) ◽  
pp. 433-445 ◽  
Author(s):  
Cynthia Lilian Andoniadou ◽  
Danielle Matsushima ◽  
Seyedeh Neda Mousavy Gharavy ◽  
Massimo Signore ◽  
Albert Ian Mackintosh ◽  
...  

1999 ◽  
Vol 11 (12) ◽  
pp. 4357-4366 ◽  
Author(s):  
Brahim Nait-Oumesmar ◽  
Laurence Decker ◽  
François Lachapelle ◽  
Virginia Avellana-Adalid ◽  
Corinne Bachelin ◽  
...  

2021 ◽  
Author(s):  
Yao Lulu Xing ◽  
Bernard H.A. Chuang ◽  
Jasmine Poh ◽  
Kaveh Moradi ◽  
Stanislaw Mitew ◽  
...  

Approaches to investigate adult oligodendrocyte progenitor cells (OPCs) by targeted cell ablation in the rodent central nervous system have been limited by methodological challenges resulting in only partial and transient OPC depletion. We have developed a novel pharmacogenetic model of conditional OPC ablation, resulting in the elimination of 99.7% of all OPCs throughout the brain. By combining recombinase-based transgenic and viral strategies for targeting of OPCs and ventricular-subventricular zone (V-SVZ)-derived neural precursor cells (NPCs), we found that new PDGFRα-expressing cells born in the V-SVZ repopulated the OPC-deficient brain starting 12 days after OPC ablation. Our data reveal that OPC depletion induces V-SVZ-derived NPCs to generate vast numbers of PDGFRα+/NG2+ cells with the capacity to migrate and proliferate extensively throughout the dorsal anterior forebrain. Further application of this novel approach to ablate OPCs will advance knowledge of the function of both OPCs and oligodendrogenic NPCs in health and disease.


2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Per Flodby ◽  
Zea Borok ◽  
Danping Gao ◽  
Yong Ho Kim ◽  
Kwang-Jin Kim ◽  
...  

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