scholarly journals Hedgehog Signaling Regulates Brain Tumor-Initiating Cell Proliferation and Portends Shorter Survival for Patients with PTEN-Coexpressing Glioblastomas

Stem Cells ◽  
2008 ◽  
Vol 26 (12) ◽  
pp. 3018-3026 ◽  
Author(s):  
Qijin Xu ◽  
Xiangpeng Yuan ◽  
Gentao Liu ◽  
Keith L. Black ◽  
John S. Yu
Keyword(s):  
Cell Proliferation ◽  
Brain Tumor ◽  
Hedgehog Signaling ◽  
Tumor Initiating Cell

scholarly journals Itraconazole inhibits the Hedgehog signaling pathway thereby inducing autophagy-mediated apoptosis of colon cancer cells

2020 ◽  
Vol 11 (7) ◽  
Author(s):  
Huiming Deng ◽  
Ling Huang ◽  
Zhongkai Liao ◽  
Mi Liu ◽  
Qiang Li ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Hedgehog Signaling ◽  
Colon Cancer Cell ◽  
Hedgehog Signaling Pathway ◽  
Colon Cancer Cells ◽  
Hct 116

AbstractItraconazole is as an antifungal medication used to treat systemic fungal infections. Recently, it has been reported to be effective in suppressing tumor growth by inhibiting the Hedgehog signaling pathway and angiogenesis. In the present study, we investigated whether itraconazole induces autophagy-mediated cell death of colon cancer cells through the Hedgehog signaling pathway. Cell apoptosis and cell cycle distribution of the colon cancer cell lines SW-480 and HCT-116 were detected by flow cytometry and terminal TUNEL assay. Autophagy and signal proteins were detected by western blotting and cell proliferation-associated antigen Ki-67 was measured using immunohistochemistry. The images of autophagy flux and formation of autophagosomes were observed by laser scanning confocal and/or transmission electron microscopy. Colon cancer cell xenograft mouse models were also established. Itraconazole treatment inhibited cell proliferation via G1 cell cycle arrest as well as autophagy-mediated apoptosis of SW-480 and HCT-116 colon cancer cells. In addition, the Hedgehog pathway was found to be involved in activation of itraconazole-mediated autophagy. After using the Hedgehog agonist recombinant human Sonic Hedgehog (rhshh), itraconazole could counteract the activation of rhshh. Moreover, treatment with itraconazole produced significant cancer inhibition in HCT-116-bearing mice. Thus, itraconazole may be a potential and effective therapy for the treatment of colon cancer.

Hedgehog Signaling and Maintenance of Homeostasis in the Intestinal Epithelium

Physiology ◽  
2012 ◽  
Vol 27 (3) ◽  
pp. 148-155 ◽  
Author(s):  
Nikè V. J. A. Büller ◽  
Sanne L. Rosekrans ◽  
Jessica Westerlund ◽  
Gijs R. van den Brink
Keyword(s):  
Cell Proliferation ◽  
Negative Feedback ◽  
Intestinal Epithelium ◽  
Hedgehog Signaling ◽  
Dynamic Equilibrium ◽  
Indian Hedgehog ◽  
Feedback Signal ◽  
Epithelial Integrity

Homeostasis of the rapidly renewing intestinal epithelium depends on a balance between cell proliferation and loss. Indian hedgehog (Ihh) acts as a negative feedback signal in this dynamic equilibrium. We discuss recent evidence that Ihh may be one of the key epithelial signals that indicates epithelial integrity to the underlying mesenchyme.

scholarly journals Sonic Hedgehog Signaling Promotes Peri-Lesion Cell Proliferation and Functional Improvement after Cortical Contusion Injury

2021 ◽  
Vol 2 (1) ◽  
pp. 27-38
Author(s):  
Ashley K. Pringle ◽  
Elshadaie Solomon ◽  
Benjamin J. Coles ◽  
Brandon R. Desousa ◽  
Anan Shtaya ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Sonic Hedgehog ◽  
Hedgehog Signaling ◽  
Functional Improvement ◽  
Sonic Hedgehog Signaling ◽  
Contusion Injury ◽  
Cortical Contusion
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