scholarly journals Mood Stabilizing Drugs Expand the Neural Stem Cell Pool in the Adult Brain Through Activation of Notch Signaling

Stem Cells ◽  
2008 ◽  
Vol 26 (7) ◽  
pp. 1758-1767 ◽  
Author(s):  
Mikito Higashi ◽  
Noriko Maruta ◽  
Alan Bernstein ◽  
Kazuhiro Ikenaka ◽  
Seiji Hitoshi
Keyword(s):  
Stem Cell ◽  
Notch Signaling ◽  
Neural Stem Cell ◽  
Adult Brain ◽  
Cell Pool ◽  
Stem Cell Pool

scholarly journals Autocrine Mfge8 Signaling Prevents Developmental Exhaustion of the Adult Neural Stem Cell Pool

2018 ◽  
Vol 23 (3) ◽  
pp. 444-452.e4 ◽  
Author(s):  
Yi Zhou ◽  
Allison M. Bond ◽  
Jamie E. Shade ◽  
Yunhua Zhu ◽  
Chung-ha O. Davis ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Adult Neural Stem Cell ◽  
Cell Pool ◽  
Stem Cell Pool

scholarly journals The Small GTPase RhoA Is Required to Maintain Spinal Cord Neuroepithelium Organization and the Neural Stem Cell Pool

2011 ◽  
Vol 31 (13) ◽  
pp. 5120-5130 ◽  
Author(s):  
D. Herzog ◽  
P. Loetscher ◽  
J. van Hengel ◽  
S. Knusel ◽  
C. Brakebusch ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cell ◽  
Neural Stem Cell ◽  
Small Gtpase ◽  
Cell Pool ◽  
Stem Cell Pool

Pax6 maintains the EGF-responsive neural stem cell pool in the SVZ

2010 ◽  
Vol 34 (8) ◽  
pp. S38-S38
Author(s):  
Qikuan Hu ◽  
Meiyu Li ◽  
Haitao Jia ◽  
Hong Tao ◽  
Jie bai ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Cell Pool ◽  
Stem Cell Pool

scholarly journals Hes1 overexpression leads to expansion of embryonic neural stem cell pool and stem cell reservoir in the postnatal brain

Development ◽  
2021 ◽  
Vol 148 (4) ◽  
pp. dev189191
Author(s):  
Toshiyuki Ohtsuka ◽  
Ryoichiro Kageyama
Keyword(s):  
Stem Cell ◽  
Subventricular Zone ◽  
Radial Glia ◽  
Adult Brain ◽  
Postnatal Brain ◽  
Neocortical Development ◽  
Cell Pool ◽  
Hes1 Expression ◽  
Embryonic Neural Stem Cell ◽  
Stem Cell Pool

ABSTRACTNeural stem cells (NSCs) gradually alter their characteristics during mammalian neocortical development, resulting in the production of various neurons and glial cells, and remain in the postnatal brain as a source of adult neurogenesis. Notch-Hes signaling is a key regulator of stem cell properties in the developing and postnatal brain, and Hes1 is a major effector that strongly inhibits neuronal differentiation and maintains NSCs. To manipulate Hes1 expression levels in NSCs, we generated transgenic (Tg) mice using the Tet-On system. In Hes1-overexpressing Tg mice, NSCs were maintained in both embryonic and postnatal brains, and generation of later-born neurons was prolonged until later stages in the Tg neocortex. Hes1 overexpression inhibited the production of Tbr2+ intermediate progenitor cells but instead promoted the generation of basal radial glia-like cells in the subventricular zone (SVZ) at late embryonic stages. Furthermore, Hes1-overexpressing Tg mice exhibited the expansion of NSCs and enhanced neurogenesis in the SVZ of adult brain. These results indicate that Hes1 overexpression expanded the embryonic NSC pool and led to the expansion of the NSC reservoir in the postnatal and adult brain.

Ulk4 Regulates Neural Stem Cell Pool

Stem Cells ◽  
2016 ◽  
Vol 34 (9) ◽  
pp. 2318-2331 ◽  
Author(s):  
Min Liu ◽  
Zhenlong Guan ◽  
Qin Shen ◽  
Frances Flinter ◽  
Laura Domínguez ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Cell Pool ◽  
Stem Cell Pool
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