scholarly journals Sonic Hedgehog Stimulates Mouse Embryonic Stem Cell Proliferation by Cooperation of Ca2+/Protein Kinase C and Epidermal Growth Factor Receptor As Well as Gli1 Activation

Stem Cells ◽  
2007 ◽  
Vol 25 (12) ◽  
pp. 3069-3080 ◽  
Author(s):  
Jung Sun Heo ◽  
Min Young Lee ◽  
Ho Jae Han
Keyword(s):  
Cell Proliferation ◽  
Epidermal Growth Factor Receptor ◽  
Stem Cell ◽  
Sonic Hedgehog ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cell ◽  
Growth Factor Receptor ◽  
Stem Cell Proliferation ◽  
Kinase C ◽  
Epidermal Growth

scholarly journals Nitric Oxide Decreases Subventricular Zone Stem Cell Proliferation by Inhibition of Epidermal Growth Factor Receptor and Phosphoinositide-3-Kinase/Akt Pathway

Stem Cells ◽  
2006 ◽  
Vol 25 (1) ◽  
pp. 88-97 ◽  
Author(s):  
Ana Torroglosa ◽  
Maribel Murillo-Carretero ◽  
Carmen Romero-Grimaldi ◽  
Esperanza R. Matarredona ◽  
Antonio Campos-Caro ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cell Proliferation ◽  
Epidermal Growth Factor Receptor ◽  
Stem Cell ◽  
Subventricular Zone ◽  
Growth Factor Receptor ◽  
Akt Pathway ◽  
Stem Cell Proliferation ◽  
Epidermal Growth ◽  
Phosphoinositide 3 Kinase

scholarly journals Effects of Oxidative Stress on Mouse Embryonic Stem Cell Proliferation, Apoptosis, Senescence, and Self-Renewal

2010 ◽  
Vol 19 (9) ◽  
pp. 1321-1331 ◽  
Author(s):  
Yan-Lin Guo ◽  
Samujjwal Chakraborty ◽  
Suja S. Rajan ◽  
Rouxing Wang ◽  
Faqing Huang
Keyword(s):  
Oxidative Stress ◽  
Cell Proliferation ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cell ◽  
Self Renewal ◽  
Stem Cell Proliferation

scholarly journals 14-3-3σ Regulates β-Catenin-Mediated Mouse Embryonic Stem Cell Proliferation by Sequestering GSK-3β

PLoS ONE ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. e40193 ◽  
Author(s):  
Tzu-Ching Chang ◽  
Chia-Chia Liu ◽  
En-Wei Hsing ◽  
Shu-Man Liang ◽  
Ya-Hui Chi ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cell ◽  
Stem Cell Proliferation ◽  
Gsk 3Β

scholarly journals Bidirectional Regulation of Mouse Embryonic Stem Cell Proliferation by Nicotine Is Mediated Through Wnt Signaling Pathway

Dose-Response ◽  
2017 ◽  
Vol 15 (4) ◽  
pp. 155932581773976 ◽  
Author(s):  
Qinglan Qu ◽  
Fengrong Zhang ◽  
Xiang Zhang ◽  
Weihong Yin
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cell ◽  
Biologically Active ◽  
Stem Cell Proliferation ◽  
Bidirectional Regulation

Introduction: Nicotine is a key biologically active compound of cigarettes. Although nicotine is a risk factor for various health issues, it may also be beneficial when treated at moderate concentrations. Nicotine has been shown to bidirectionally regulate stem cell proliferation and differentiation depending on the doses applied. It is not clear whether or how nicotine regulates mouse embryonic stem cell (mESC) survival and proliferation. Methods: Mouse embryonic stem cells were cultured in the presence of 0.01, 0.1, 1, or 10 μM nicotine. The effects of nicotine on cell survival and proliferation were examined. The signaling pathway that mediated these effects was analyzed. Results: Cell viability was not affected by nicotine at all 4 concentrations examined. The proliferation of mESCs was promoted by 0.01 and 0.1 μM nicotine and suppressed by 1 and 10 μM. This dose-dependent regulation was mediated through the Wnt/β-catenin pathway. Modulation of Wnt/β-catenin activity either worsens or reverses the effects of nicotine. Conclusions: We have identified a bidirectional function of nicotine on mESC proliferation through regulation of the Wnt/β-catenin pathway and this is associated with different doses. This study suggests that concentration of nicotine is a crucial aspect for consideration when designing research or therapeutic strategies.

Activation of protein kinase C delta by ψδRACK peptide promotes embryonic stem cell proliferation through ERK 1/2

2013 ◽  
Vol 94 ◽  
pp. 497-512 ◽  
Author(s):  
Nicole Milaré Garavello ◽  
Darlene Aparecida Pena ◽  
José Matheus Camargo Bonatto ◽  
Mariana Lemos Duarte ◽  
Helio Miranda Costa-Junior ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Protein Kinase C Delta ◽  
Stem Cell Proliferation ◽  
Kinase C
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