scholarly journals Suppression of Hepatocyte Growth Factor Production Impairs the Ability of Adipose-Derived Stem Cells to Promote Ischemic Tissue Revascularization

Stem Cells ◽  
2007 ◽  
Vol 25 (12) ◽  
pp. 3234-3243 ◽  
Author(s):  
Liying Cai ◽  
Brian H. Johnstone ◽  
Todd G. Cook ◽  
Zhong Liang ◽  
Dmitry Traktuev ◽  
...  
Keyword(s):  
Stem Cells ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Adipose Derived Stem Cells ◽  
Factor Production ◽  
Ischemic Tissue ◽  
Growth Factor Production ◽  
Hepatocyte Growth

scholarly journals Differential Role of Neutrophils and Alveolar Macrophages in Hepatocyte Growth Factor Production in Pulmonary Fibrosis

2002 ◽  
Vol 82 (8) ◽  
pp. 1015-1022 ◽  
Author(s):  
Bruno Crestani ◽  
Monique Dehoux ◽  
Gilles Hayem ◽  
Véronique Leçon ◽  
Francine Hochedez ◽  
...  
Keyword(s):  
Growth Factor ◽  
Pulmonary Fibrosis ◽  
Hepatocyte Growth Factor ◽  
Alveolar Macrophages ◽  
Factor Production ◽  
Growth Factor Production ◽  
Hepatocyte Growth

scholarly journals Human adipose-derived stem cells pre-treated with platelet-rich plasma and hepatocyte growth factor alleviate liver fibrosis in mice

2018 ◽  
Vol 5 (5) ◽  
pp. 2332-2348 ◽  
Author(s):  
Nam H. Nguyen ◽  
Trinh V. Le ◽  
Huy Q. Do ◽  
Thanh M. Dang ◽  
Yen K. T. Nguyen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Growth Factor ◽  
Liver Fibrosis ◽  
Hepatocyte Growth Factor ◽  
Platelet Rich Plasma ◽  
Smooth Muscle Actin ◽  
Mrna Levels ◽  
Adipose Derived Stem Cells ◽  
Healthy Human ◽  
Hepatocyte Growth

Background: Transplantation of adipose-derived stem cells (ADSCs) is a potential therapy for a variety of liver diseases. Previous studies have shown that ADSC-based therapy is promising for liver fibrosis treatment. Recently, many publications have suggested that pretreating ADSCs with growth factors before transplantation can elevate the effectiveness of the therapy. Therefore, we hypothesize that human ADSCs (hADSCs) pretreated with platelet-rich plasma (PRP) and hepatocyte growth factor (HGF), compared to ADSCs alone, would accelerate the treatment effects on liver fibrosis in mice. Methods: The hADSCs were cultured solely with conventional media, or with HGF (human recombinant; 20 ng/ml), or with HGF and PRP (from healthy human blood, 10%), concomitantly added to the medium for 7 days before transplantation. Eight-week-old male mice were treated with CCl4 (1 ml/kg) for 11 weeks to induce liver fibrosis. The mice were then subsequently divided into: 1) Placebo group (PBS injection); 2) ADSCs/HGF+PRP (5x105HGF and PRP pre-treated cells/mice); 3) ADSCs/HGF (5x105HGF pre-treated cells/mice) and 4) ADSCs (5x105non-pretreated cells/mice). Results: Seven days post-transplantation, the alanine transaminase (ALT) level in the placebo was notably elevated (143.10±14.96 IU/L), compared to ALT levels of ADSCs-, ADSCs/HGF+PR-, and ADSCs/HGF-transplanted mice, which showed an improvement (67.94±18.57 IU/L, 49.44±7.56 IU/L, and 57.93±5.75 IU/L, respectively). The procollagen-α1 and alpha-smooth muscle actin (α-SMA) mRNA levels were significantly down-regulated in the ADSCs-transplanted group compared to those of the placebo. Importantly, these levels were lower in ADSCs/HGF+PR (procollagen-α1: 75.64±45.89; α-SMA: 36.17±36.09) than those of ADSCs/HGF (procollagen-α1: 212.8±84.35; α-SMA: 52.41±7.93) and ADSCs only (procollagen-α1: 310.50 ± 55.36; α-SMA: 184.70±14.06). Stem cell transplantation also improved histological index, reducing inflammation and collagen/necrotic structure accumulation. However, there were no statistical differences between three ADSCs treatment groups after 14 days after transplantation. Conclusion: Pre-treatment with PRP and HGF for 7 days enhanced the efficacy of ADSCs in alleviating liver fibrosis in vivo.

scholarly journals Inhibition of Hepatocyte Growth Factor Production in Human Fibroblasts by Ursodeoxycholic Acid

2005 ◽  
Vol 28 (4) ◽  
pp. 619-624 ◽  
Author(s):  
Kaori Hiramatsu ◽  
Yohsuke Matsumoto ◽  
Masahiro Miyazaki ◽  
Hirohito Tsubouchi ◽  
Itaru Yamamoto ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Ursodeoxycholic Acid ◽  
Human Fibroblasts ◽  
Factor Production ◽  
Growth Factor Production ◽  
Hepatocyte Growth

scholarly journals Exercise-Induced Hepatocyte Growth Factor Production in Patients After Acute Myocardial Infarction

2004 ◽  
Vol 68 (4) ◽  
pp. 304-307 ◽  
Author(s):  
Satoshi Yasuda ◽  
Yoichi Goto ◽  
Hiroshi Takaki ◽  
Yasuhide Asaumi ◽  
Takeshi Baba ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Factor Production ◽  
Growth Factor Production ◽  
Exercise Induced ◽  
Hepatocyte Growth

Promoting Effects on Hepatocyte Growth Factor Production of Daphnane Diterpenoids from Daphne odora

Heterocycles ◽  
2013 ◽  
Vol 87 (5) ◽  
pp. 1087 ◽  
Author(s):  
Hideyuki Shigemori ◽  
Rie Nakasone ◽  
Manami Kurisu ◽  
Manami Onodera ◽  
Yusaku Miyamae ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Factor Production ◽  
Daphne Odora ◽  
Growth Factor Production ◽  
Hepatocyte Growth
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