scholarly journals Bone Marrow-Derived Cells Contribute to Podocyte Regeneration and Amelioration of Renal Disease in a Mouse Model of Alport Syndrome

Stem Cells ◽  
2006 ◽  
Vol 24 (11) ◽  
pp. 2448-2455 ◽  
Author(s):  
Evangelia I. Prodromidi ◽  
Richard Poulsom ◽  
Rosemary Jeffery ◽  
Candice A. Roufosse ◽  
Patrick J. Pollard ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mouse Model ◽  
Renal Disease ◽  
Alport Syndrome ◽  
Bone Marrow Derived Cells ◽  
Podocyte Regeneration

scholarly journals Characterization of cell fusion in an experimental mouse model of endometriosis†

2018 ◽  
Vol 100 (2) ◽  
pp. 390-397 ◽  
Author(s):  
A Tal ◽  
R Tal ◽  
S Shaikh ◽  
S Gidicsin ◽  
R Mamillapalli ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mouse Model ◽  
Cell Fusion ◽  
Bone Marrow Cells ◽  
Low Frequency ◽  
Uterine Cavity ◽  
Stromal Compartment ◽  
Experimental Mouse Model ◽  
Experimental Mouse ◽  
Bone Marrow Derived Cells

Abstract Cell fusion is involved in the development of some adult organs, is implicated in the pathogenesis of specific types of cancer, and is known to participate in repair/regeneration processes mediated by bone-marrow-derived cells (BMDCs). Endometriosis is a disease characterized by growth of functional endometrial tissue outside of the uterine cavity. Endometriosis shares some molecular properties with cancer and BMDCs home to endometriosis lesions in a mouse model. Our objective was to determine if cell fusion can occur in endometriosis and establish whether bone-marrow-derived cells participate in cell fusion events in lesions. We employed a Cre-Lox system to identify cell fusion events in a mouse model of endometriosis. Fused cells were detected in endometriotic lesions, albeit at a low frequency (∼1 in 400 cells), localized to the stromal compartment, and displayed restricted proliferation. Using 5-fluorouracil-based nongonadotoxic bone marrow transplantation model, we demonstrate that bone marrow cells represent a principal cell source for fusion events in lesions. Cell fusion progeny uniformly lacked expression of selected markers of hematopoietic, endothelial, and epithelial markers, though they expressed the mesenchymal/stromal markers Sca-1 and CD29. This study is the first to describe the phenomenon of cell fusion in endometriosis and points to a mesenchymal population derived from cell fusion events with limited proliferative activity, properties previously attributed to endometrial stem cells. Their putative role in the pathogenesis of the disease remains to be elucidated.

scholarly journals Bone marrow-derived cells or C-X-C motif chemokine 12 (CXCL12) treatment improve thin endometrium in a mouse model†

2018 ◽  
Vol 100 (1) ◽  
pp. 61-70 ◽  
Author(s):  
Kyong Wook Yi ◽  
Ramanaiah Mamillapalli ◽  
Cagdas Sahin ◽  
Jaeyen Song ◽  
Reshef Tal ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mouse Model ◽  
Thin Endometrium ◽  
Bone Marrow Derived Cells

Systemically Transplanted Bone Marrow–derived Cells Contribute to Dental Pulp Regeneration in a Chimeric Mouse Model

2016 ◽  
Vol 42 (2) ◽  
pp. 263-268 ◽  
Author(s):  
Wenan Xu ◽  
Shan Jiang ◽  
Qiuyue Chen ◽  
Yanyan Ye ◽  
Jiajing Chen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mouse Model ◽  
Dental Pulp ◽  
Chimeric Mouse ◽  
Pulp Regeneration ◽  
Bone Marrow Derived Cells ◽  
Chimeric Mouse Model

scholarly journals Chimeric Mouse model to track the migration of bone marrow derived cells in glioblastoma following anti-angiogenic treatments

2016 ◽  
Vol 17 (3) ◽  
pp. 280-290 ◽  
Author(s):  
B. R. Achyut ◽  
Adarsh Shankar ◽  
A. S. M. Iskander ◽  
Roxan Ara ◽  
Robert A. Knight ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mouse Model ◽  
Chimeric Mouse ◽  
Bone Marrow Derived Cells ◽  
Chimeric Mouse Model

scholarly journals Bone marrow-derived cells do not repair endothelium in a mouse model of chronic endothelial cell dysfunction

2009 ◽  
Vol 84 (2) ◽  
pp. 317-325 ◽  
Author(s):  
Tashera E. Perry ◽  
Minjung Song ◽  
Daryl J. Despres ◽  
Soo Mi Kim ◽  
Hong San ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Endothelial Cell ◽  
Mouse Model ◽  
Endothelial Cell Dysfunction ◽  
Cell Dysfunction ◽  
Bone Marrow Derived Cells

Bone marrow–derived cells participate in the long-term remodeling in a mouse model of esophageal reconstruction

2013 ◽  
Vol 182 (1) ◽  
pp. e1-e7 ◽  
Author(s):  
Alejandro Nieponice ◽  
Thomas W. Gilbert ◽  
Scott A. Johnson ◽  
Neill J. Turner ◽  
Stephen F. Badylak
Keyword(s):  
Bone Marrow ◽  
Mouse Model ◽  
Esophageal Reconstruction ◽  
Bone Marrow Derived Cells
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