scholarly journals In Vitro Culture During Retroviral Transduction Improves Thymic Repopulation and Output After Total Body Irradiation and Autologous Peripheral Blood Progenitor Cell Transplantation in Rhesus Macaques

Stem Cells ◽  
2006 ◽  
Vol 24 (6) ◽  
pp. 1539-1548 ◽  
Author(s):  
Karin Loré ◽  
Ruth Seggewiss ◽  
F. Javier Guenaga ◽  
Stefania Pittaluga ◽  
Robert E. Donahue ◽  
...  
Keyword(s):  
In Vitro Culture ◽  
Cell Transplantation ◽  
Total Body Irradiation ◽  
Peripheral Blood ◽  
Progenitor Cell ◽  
Rhesus Macaques ◽  
Peripheral Blood Progenitor Cell ◽  
Retroviral Transduction ◽  
Total Body

Hematologic Changes After Total Body Irradiation and Autologous Transplantation of Hematopoietic Peripheral Blood Progenitor Cells in Dogs With Lymphoma

2011 ◽  
Vol 49 (2) ◽  
pp. 341-343 ◽  
Author(s):  
C. Escobar ◽  
C. Grindem ◽  
J. A. Neel ◽  
S. E. Suter
Keyword(s):  
Blood Cell ◽  
Progenitor Cells ◽  
Cell Lines ◽  
Total Body Irradiation ◽  
Peripheral Blood ◽  
Progenitor Cell ◽  
Peripheral Blood Cell ◽  
Peripheral Blood Progenitor Cell ◽  
Cell Transplant ◽  
Total Body

Dogs with and without lymphoma have undergone hematopoietic cell transplantation in a research setting for decades. North Carolina State University is currently treating dogs with B- and T-cell lymphoma in a clinical setting with autologous peripheral blood progenitor cell transplants, using peripheral blood CD34+ progenitor cells harvested using an apheresis machine. Complete blood counts were performed daily for 15 to 19 days posttransplantation to monitor peripheral blood cell nadirs and subsequent CD34+ cell engraftment. This study documents the hematologic toxicities of total body irradiation in 10 dogs and the subsequent recovery of the affected cell lines after peripheral blood progenitor cell transplant, indicating successful CD34+ engraftment. All peripheral blood cell lines, excluding red blood cells, experienced grade 4 toxicities. All dogs had ≥ 500 neutrophils/μl by day 12, while thrombocytopenia persisted for many weeks. All dogs were clinically normal at discharge.

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