scholarly journals The Serum Lipid Lowering Effect of Rugosa Rose Petal Extract Rich in Polyphenols in Adults with High Serum Triglyceride

2015 ◽  
Vol 12 (1) ◽  
pp. 29-35
Author(s):  
Takashi YAMAGISHI ◽  
Keiji TAKANO ◽  
Sumio KONDO
Keyword(s):  
Serum Lipid ◽  
Serum Triglyceride ◽  
High Serum ◽  
Lipid Lowering ◽  
Lowering Effect ◽  
Rose Petal ◽  
Lipid Lowering Effect

Serum lipid-lowering effect of vinca alkaloids

1979 ◽  
Vol 28 (2) ◽  
pp. 227-230 ◽  
Author(s):  
T. Kremmer ◽  
L. Holczinger ◽  
Susan Somfai-Relle
Keyword(s):  
Serum Lipid ◽  
Lipid Lowering ◽  
Vinca Alkaloids ◽  
Lowering Effect ◽  
Lipid Lowering Effect

scholarly journals Comparison of Lipid Lowering Effect of Aqueous Extract of Cinnamon (Cinnamomum Cassiae) with that of Rosuvastatin on Experimentally Induced Hypercholesterolaemic Rats

2019 ◽  
Vol 31 (1) ◽  
pp. 52-61
Author(s):  
Sagia Afrose ◽  
Md Ismail Khan ◽  
Elisa Omar Eva ◽  
Mohammad Imtiaj Mahbub
Keyword(s):  
Serum Lipid ◽  
Lipid Level ◽  
Serum Lipid Level ◽  
Lipid Lowering ◽  
High Cholesterol Diet ◽  
P Value ◽  
High Cholesterol ◽  
Lowering Effect ◽  
Lipid Lowering Effect ◽  
Experimentally Induced

Background: Hypercholesterolemia is a condition characterized by very high level of cholesterol in the blood. Too much cholesterol increases risk of developing heart disease called coronary artery disease. This condition occurs when excess cholesterol in the bloodstream is deposited in the walls of blood vessels, particularly in the coronary arteries that supply blood to the heart. A phenolic compound of the cinnamon extract lowers serum lipid level by inhibiting HMG COA reductase & by activation of nuclear receptor peroxisome proliferator activated receptor alpha (PPAR-α). We are trying to evaluate the lipid lowering effect of cinnamon (Cinnamomum cassiae) in comparison with rosuvastatin in hypercholesterolaemic rats. Aim: To find out the lipid lowering effect of aqueous extract of cinnamon (Cinnamomum cassiae) and compare it with a established lipid lowering drug (rosuvastatin) on hypercholesterolaemic rats. Method: This was a experimental study conducted in the department of Pharmacology, Dhaka medical college & Hospital from July 2015 to June 2016. Sample size was 30.The study was designed as 2 parts: Experiment-1 & Experiment -2. Result: Cinnamon produces no statistically significant effect on serum lipid level of healthy rats (P- value >0.05; which is not significant). Cinnamon significantly reduced serum lipid level of high cholesterol diet induced hypercholesterolaemic rats. But, there is statistically significant difference between cinnamon and rosuvastatin lipid lowering effect in high cholesterol diet induced hypercholesterolaemic rats (p value <0.05; which is significant). Conclusion: The study was conducted to find out lipid lowering effect of cinnamon on experimentally induced hypercholesterolaemic rats. The present study found that cinnamon (Cinnamomum cassaiae) significantly lowers serum lipid level in experimentally induced hypercholesterolaemic rats. So cinnamon can be used as alternative lipid lowering agent for its easy availability, cost effectiveness and as well as lack of significant side effects. TAJ 2018; 31(1): 52-61

scholarly journals Bai-Hu-Jia-Ren-Shen-Tang Decoction Reduces Fatty Liver by Activating AMP-Activated Protein Kinase In Vitro and In Vivo

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Hui-Kang Liu ◽  
Tzu-Min Hung ◽  
Hsiu-Chen Huang ◽  
I-Jung Lee ◽  
Chia-Chuan Chang ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Fatty Liver ◽  
Lipid Accumulation ◽  
Serum Triglyceride ◽  
Total Lipid Content ◽  
Lipid Lowering ◽  
Acid Oxidation ◽  
Lowering Effect ◽  
Amp Activated Protein Kinase ◽  
Lipid Lowering Effect

Obesity and associated conditions, such as type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD), are currently a worldwide health problem. In Asian traditional medicine, Bai-Hu-Jia-Ren-Shen-Tang (BHJRST) is widely used in diabetes patients to reduce thirst. However, whether it has a therapeutic effect on T2DM or NAFLD is not known. The aim of this study was to examine whether BHJRST had a lipid-lowering effect using a HuS-E/2 cell model of fatty liver induced by palmitate and in a db/db mouse model of dyslipidemia. Incubation of HuS-E/2 cells with palmitate markedly increased lipid accumulation and expression of adipose triglyceride lipase (ATGL), which is involved in lipolysis. BHJRST significantly decreased lipid accumulation and increased ATGL levels and phosphorylation of AMP-activated protein kinase (AMPK) and its primary downstream target, acetyl-CoA carboxylase (ACC), which are involved in fatty acid oxidation. Furthermore, after twice daily oral administration for six weeks, BHJRST significantly reduced hepatic fat accumulation in db/db mice, as demonstrated by increased hepatic AMPK and ACC phosphorylation, reduced serum triglyceride levels, and reduced hepatic total lipid content. The results show that BHJRST has a lipid-lowering effect in the liver that is mediated by activation of the AMPK signaling pathway.

scholarly journals Serum Lipid Lowering Effect of DHA Supplemented Bread.

2001 ◽  
Vol 50 (8) ◽  
pp. 673-675 ◽  
Author(s):  
Kazunaga YAZAWA ◽  
Takashi TERANO ◽  
Tokunori MATSUI
Keyword(s):  
Serum Lipid ◽  
Lipid Lowering ◽  
Lowering Effect ◽  
Lipid Lowering Effect

Phytochemical, Nutrient Composition and Serum Lipid Lowering Effect of Xylopia aethiopica Fruit

2014 ◽  
Vol 4 (17) ◽  
pp. 2096-2105 ◽  
Author(s):  
Yusuf Omeh ◽  
Samuel Onoja ◽  
Maxwell Ezeja ◽  
S. Bassey ◽  
G. Ogbenta ◽  
...  
Keyword(s):  
Serum Lipid ◽  
Nutrient Composition ◽  
Lipid Lowering ◽  
Lowering Effect ◽  
Xylopia Aethiopica ◽  
Lipid Lowering Effect

Does chenodesoxycholic acid have a lipid lowering effect in primary hyperlipoproteinemia?

1976 ◽  
Vol 10 (2) ◽  
pp. 147-149 ◽  
Author(s):  
G. Schlierf ◽  
A. Stiehl ◽  
C. C. Heuck ◽  
P. D. Lang ◽  
P. Oster ◽  
...  
Keyword(s):  
Lipid Lowering ◽  
Lowering Effect ◽  
Lipid Lowering Effect
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