scholarly journals Analysis of erb-b2 receptor tyrosine kinase 2 (ERBB2)-, and BCAR1, Cas family scaffolding protein (BCAR1)-dependent transcriptomes in human MCF10A breast cancer cells

2019 ◽  
Author(s):  
E Medico
Keyword(s):  
Breast Cancer ◽  
Tyrosine Kinase ◽  
Cancer Cells ◽  
Receptor Tyrosine Kinase ◽  
Breast Cancer Cells ◽  
Scaffolding Protein ◽  
Tyrosine Kinase 2

scholarly journals Erb-b2 Receptor Tyrosine Kinase 2 (ERBB2) Promotes ATG12-Dependent Autophagy Contributing to Treatment Resistance of Breast Cancer Cells

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1038
Author(s):  
Yongqiang Chen ◽  
Ruobing Wang ◽  
Shujun Huang ◽  
Elizabeth S. Henson ◽  
Jayce Bi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Tyrosine Kinase ◽  
Cancer Cells ◽  
Receptor Tyrosine Kinase ◽  
Breast Cancer Cells ◽  
Treatment Resistance ◽  
Tyrosine Kinase 2 ◽  
Positive Breast Cancer ◽  
In Cells

The epidermal growth factor receptor (EGFR) family member erb-b2 receptor tyrosine kinase 2 (ERBB2) is overexpressed in many types of cancers leading to (radio- and chemotherapy) treatment resistance, whereas the underlying mechanisms are still unclear. Autophagy is known to contribute to cancer treatment resistance. In this study, we demonstrate that ERBB2 increases the expression of different autophagy genes including ATG12 (autophagy-related 12) and promotes ATG12-dependent autophagy. We clarify that lapatinib, a dual inhibitor for EGFR and ERBB2, promoted autophagy in cells expressing only EGFR but inhibited autophagy in cells expressing only ERBB2. Furthermore, breast cancer database analysis of 35 genes in the canonical autophagy pathway shows that the upregulation of ATG12 and MAP1LC3B is associated with a low relapse-free survival probability of patients with ERBB2-positive breast tumors following treatments. Downregulation of ERBB2 or ATG12 increased cell death induced by chemotherapy drugs in ERBB2-positive breast cancer cells, whereas upregulation of ERBB2 or ATG12 decreased the cell death in ERBB2-negative breast cancer cells. Finally, ERBB2 antibody treatment led to reduced expression of ATG12 and autophagy inhibition increasing drug or starvation-induced cell death in ERBB2-positive breast cancer cells. Taken together, this study provides a novel approach for the treatment of ERBB2-positive breast cancer by targeting ATG12-dependent autophagy.

scholarly journals Targeting the EphB4 receptor tyrosine kinase sensitizes HER2-positive breast cancer cells to Lapatinib

2020 ◽  
Vol 475 ◽  
pp. 53-64 ◽  
Author(s):  
Jinlei Ding ◽  
Yating Yao ◽  
Gena Huang ◽  
Xiaonan Wang ◽  
Jingyan Yi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tyrosine Kinase ◽  
Cancer Cells ◽  
Receptor Tyrosine Kinase ◽  
Breast Cancer Cells ◽  
Her2 Positive ◽  
Her2 Positive Breast Cancer ◽  
Positive Breast Cancer

scholarly journals Araguspongine C Induces Autophagic Death in Breast Cancer Cells through Suppression of c-Met and HER2 Receptor Tyrosine Kinase Signaling

Marine Drugs ◽  
2015 ◽  
Vol 13 (1) ◽  
pp. 288-311 ◽  
Author(s):  
Mohamed Akl ◽  
Nehad Ayoub ◽  
Hassan Ebrahim ◽  
Mohamed Mohyeldin ◽  
Khaled Orabi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tyrosine Kinase ◽  
Cancer Cells ◽  
Receptor Tyrosine Kinase ◽  
Breast Cancer Cells ◽  
Kinase Signaling ◽  
Her2 Receptor ◽  
Tyrosine Kinase Signaling
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