scholarly journals Analysis of the enhancer of zeste 2 polycomb repressive complex 2 subunit (Ezh2)-dependent transcriptome in mouse T-cells

2019 ◽  
Author(s):  
I Su
Keyword(s):  
T Cells ◽  
Polycomb Repressive Complex ◽  
Polycomb Repressive Complex 2 ◽  
Enhancer Of Zeste

The polycomb repressive complex 2 governs life and death of peripheral T cells

Blood ◽  
2014 ◽  
Vol 124 (5) ◽  
pp. 737-749 ◽  
Author(s):  
Yuxia Zhang ◽  
Sarah Kinkel ◽  
Jovana Maksimovic ◽  
Esther Bandala-Sanchez ◽  
Maria C. Tanzer ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Th2 Cells ◽  
Polycomb Repressive Complex ◽  
Th Cells ◽  
Polycomb Repressive Complex 2 ◽  
Life And Death ◽  
Key Points ◽  
Peripheral T Cells

Key Points Ezh2 represses Ifng, Gata3, and Il10 loci in naïve CD4+T cells, and its deficiency leads to Th1 skewing and IL-10 overproduction in Th2 cells. Ezh2 deficiency activates multiple death pathways in differentiated effector Th cells.

scholarly journals Ikaros mediates gene silencing in T cells through Polycomb repressive complex 2

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Attila Oravecz ◽  
Apostol Apostolov ◽  
Katarzyna Polak ◽  
Bernard Jost ◽  
Stéphanie Le Gras ◽  
...  
Keyword(s):  
T Cells ◽  
Gene Silencing ◽  
Polycomb Repressive Complex ◽  
Polycomb Repressive Complex 2

Enhancer of zeste 2 polycomb repressive complex 2 subunit polymorphisms in melanoma skin cancer risk

2020 ◽  
Vol 29 (10) ◽  
pp. 980-986
Author(s):  
Francesca Belpinati ◽  
Giovanni Malerba ◽  
Melissa Dal Toè ◽  
Laura Ceccuzzi ◽  
Monica Rodolfo ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Cancer Risk ◽  
Polycomb Repressive Complex ◽  
Polycomb Repressive Complex 2 ◽  
Skin Cancer Risk ◽  
Enhancer Of Zeste ◽  
Melanoma Skin

scholarly journals Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit Is Required for Uterine Epithelial Integrity

2019 ◽  
Vol 189 (6) ◽  
pp. 1212-1225 ◽  
Author(s):  
Xin Fang ◽  
Nan Ni ◽  
John P. Lydon ◽  
Ivan Ivanov ◽  
Kayla J. Bayless ◽  
...  
Keyword(s):  
Polycomb Repressive Complex ◽  
Epithelial Integrity ◽  
Polycomb Repressive Complex 2 ◽  
Enhancer Of Zeste
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