Analysis of the fulvestrant (FULV) and tamoxifen (TAM)-regulated ESR1 and lysine 27-acetylated HISTH3 cistromes in MCF-7 and MCF-7 long term estrogen deprived (LTED) breast cancer cells

2019 ◽  
Author(s):  
L Magnani
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Mcf 7

Short- and long-term cytotoxic effects of doxorubicin conjugates with dendrimers and vector protein on MCF-7/MDR1 chemoresistant breast cancer cells

2017 ◽  
Author(s):  
I. A. Zamulaeva ◽  
O. N. Matchuk ◽  
K. A. Churyukina ◽  
V. A. Kudryavtzev ◽  
N. G. Yabbarov ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cytotoxic Effects ◽  
Short And Long Term ◽  
Mcf 7

scholarly journals Long-term exposure of MCF-7 breast cancer cells to ethanol stimulates oncogenic features

2016 ◽  
Vol 50 (1) ◽  
pp. 49-65 ◽  
Author(s):  
Robert Gelfand ◽  
Dolores Vernet ◽  
Kevin W. Bruhn ◽  
Suren Sarkissyan ◽  
David Heber ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Mcf 7

scholarly journals CURCUMIN INCREASES THE SENSITIVITY OF BREAST CANCER CELLS TO TAMOXIFEN BY INHIBITING MRP2 MRNA EXPRESSION OF EFFLUX TRANSPORTER MRP2

2019 ◽  
pp. 88-90
Author(s):  
DESAK GEDE BUDI KRISNAMURTI ◽  
SEPTELIA INAWATI WANANDI ◽  
MELVA LOUISA
Keyword(s):  
Breast Cancer ◽  
T Cells ◽  
Cell Viability ◽  
Mrna Expression ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Tamoxifen Treatment ◽  
Efflux Transporter ◽  
Mcf 7

Objective: Tamoxifen is the drug of choice to treat breast cancer positive for estrogen receptor. Long-term use of tamoxifen can induce multidrug resistance (MDR) associated with decreased sensitivity of cancer cells to the drug. One of the causes of MDR is overexpression of efflux transporter multidrug resistance-associated protein (MRP)2. Various drugs are known to act as MRP2 inhibitors, including curcumin. This study investigated the effects of curcumin on the sensitivity of breast cancer cells to tamoxifen through inhibition of MRP2. Methods: We used MCF-7 cells that were previously exposed to long-term tamoxifen treatment [MCF-7(T) cells]. MCF-7(T) cells were treated with 1 µM tamoxifen, curcumin (5, 10, and 20 µM), combinations of curcumin (5, 10, and 20 µM) and 1 µM tamoxifen, or 10 µM nevirapine (a known MRP2 inhibitor) for 5 d. Then, the cells were harvested, counted to assess cell viability, and evaluated for MRP2 mRNA expression. Results: Treatment with curcumin alone or in combination with tamoxifen significantly reduced cell viability at all curcumin concentrations compared with the control. The reduction in cell viability was accompanied by a reduced level of MRP2 mRNA expression. Conclusion: Application of curcumin to MCF-7 cells previously exposed to long-term tamoxifen treatment increase the sensitivity of cancer cells to tamoxifen. The increased sensitivity of these cells was attributed, at least in part, to inhibition of the efflux transporter MRP2.

Adaptation of Estrogen-regulated Genes in Long-term Estradiol Deprived MCF-7 Breast Cancer Cells

2005 ◽  
Vol 94 (3) ◽  
pp. 213-223 ◽  
Author(s):  
R. J. Santen ◽  
E. K. Lobenhofer ◽  
C. A. Afshari ◽  
Y. Bao ◽  
R. X. Song
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Mcf 7

scholarly journals Bongkrekic Acid as a Warburg Effect Modulator in Long-term Estradiol-deprived MCF-7 Breast Cancer Cells

2016 ◽  
Vol 36 (10) ◽  
pp. 5171-5182 ◽  
Author(s):  
SHUSO TAKEDA ◽  
HIROYUKI OKAZAKI ◽  
TAICHI KUDO ◽  
KAZUHIRO KAKIZOE ◽  
TAICHI HIMENO ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Warburg Effect ◽  
Breast Cancer Cells ◽  
Bongkrekic Acid ◽  
Mcf 7
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