Lithocholic acid

2015 ◽  
Author(s):  
LB Becnel ◽  
YF Darlington ◽  
S Orechsner ◽  
J Easton-Marks ◽  
CA Watkins ◽  
...  
Keyword(s):  
Lithocholic Acid

Hepatic Ultrastructure Changes Induced by Lithocholic Acid

1967 ◽  
Vol 25 ◽  
pp. 162-163 ◽  
Author(s):  
F. G. Zaki
Keyword(s):  
Endoplasmic Reticulum ◽  
Lithocholic Acid ◽  
Smooth Endoplasmic Reticulum ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Electron Microscopic ◽  
Hydropic Degeneration ◽  
Hepatic Cells ◽  
Low Protein ◽  
Microscopic Studies

Addition of lithocholic acid (LCA), a naturally occurring bile acid in mammals, to a low protein diet fed to rats induced marked inflammatory reaction in the hepatic cells followed by hydropic degeneration and ductular cell proliferation. These changes were accompanied by dilatation and hyperplasia of the common bile duct and formation of “gallstones”. All these changes were reversible when LCA was withdrawn from the low protein diet except for the hardened gallstones which persisted.Electron microscopic studies revealed marked alterations in the hepatic cells. Early changes included disorganization, fragmentation of the rough endoplasmic reticulum and detachment of its ribosomes. Free ribosomes, either singly or arranged in small clusters were frequently seen in most of the hepatic cells. Vesiculation of the smooth endoplasmic reticulum was often encountered as early as one week after the administration of LCA (Fig. 1).

Pharmacological effects of secondary bile acid microparticles in diabetic murine model

2020 ◽  
Vol 16 ◽  
Author(s):  
Armin Mooranian ◽  
Nassim Zamani ◽  
Bozica Kovacevic ◽  
Corina Mihaela Ionescu ◽  
Giuseppe Luna ◽  
...  
Keyword(s):  
Bile Acid ◽  
Blood Glucose ◽  
Bile Acids ◽  
Lithocholic Acid ◽  
Diabetes Treatment ◽  
Secondary Bile Acid ◽  
Glucose Levels ◽  
Anti Inflammatory ◽  
Antidiabetic Effects

Aim: Examine bile acids effects in Type 2 diabetes. Background: In recent studies, the bile acid ursodeoxycholic acid (UDCA) has shown potent anti-inflammatory effects in obese patients while in type 2 diabetics (T2D) levels of the pro-inflammatory bile acid lithocholic acid were increased, and levels of the anti-inflammatory bile acid chenodeoxycholic acid were decreased, in plasma. Objective: Hence, this study aimed to examine applications of novel UDCA nanoparticles in diabetes. Methods: Diabetic balb/c adult mice were divided into three equal groups and gavaged daily with either empty microcapsules, free UDCA, or microencapsulated UDCA over two weeks. Their blood, tissues, urine, and faeces were collected for blood glucose, inflammation, and bile acid analyses. UDCA resulted in modulatory effects on bile acids profile without antidiabetic effects suggesting that bile acid modulation was not directly linked to diabetes treatment. Results: UDCA resulted in modulatory effects on bile acids profile without antidiabetic effects suggesting that bile acid modulation was not directly linked to diabetes treatment. Conclusion: Bile acids modulated the bile profile without affecting blood glucose levels.

scholarly journals Metabolism of lithocholic acid in the rat: formation of lithocholic acid 3-O-glucuronide in vivo.

1990 ◽  
Vol 31 (4) ◽  
pp. 615-622
Author(s):  
JM Little ◽  
P Zimniak ◽  
KE Shattuck ◽  
R Lester ◽  
A Radominska
Keyword(s):  
Lithocholic Acid

scholarly journals Lithocholic acid: notes on purification

1980 ◽  
Vol 21 (8) ◽  
pp. 1136-1137
Author(s):  
K Budai ◽  
N B Javitt
Keyword(s):  
Lithocholic Acid

scholarly journals LITHOCHOLIC ACID GALLSTONES FROM HOG BILE

1937 ◽  
Vol 120 (2) ◽  
pp. 499-501 ◽  
Author(s):  
Rudolf Schoenheimer ◽  
Charles G. Johnston
Keyword(s):  
Lithocholic Acid

Lithocholic Acid-Based Design of Noncalcemic Vitamin D Receptor Agonists

2021 ◽  
pp. 104878
Author(s):  
Sunil Gaikwad ◽  
Carmen M. González ◽  
Daniel Vilariño ◽  
Gonzalo Lasanta ◽  
Carmen Villaverde ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Lithocholic Acid ◽  
Receptor Agonists

Synthesis of Steroid–Porphyrin Conjugates from Oestradiol, Oestrone, and Lithocholic Acid

2014 ◽  
Vol 67 (11) ◽  
pp. 1632 ◽  
Author(s):  
Fargol Taba ◽  
Tze Han Sum ◽  
Paul J. Sintic ◽  
Ann H. Lundmark ◽  
Maxwell J. Crossley
Keyword(s):  
Nucleophilic Substitution ◽  
Substitution Reaction ◽  
Lithocholic Acid ◽  
The Other ◽  
Nucleophilic Substitution Reaction ◽  
Porphyrin Synthesis ◽  
Synthesis Reactions ◽  
Steroid Conjugates ◽  
The Way

The synthesis of porphyrin–steroid conjugates is examined using the natural steroids oestradiol, oestrone, and lithocholic acid as precursors. Two strategies differing in the timing of formation of the steroid–porphyrin linkage leading to four different construction motifs are explored. Two approaches are based on a strategy of introduction of steroidal components in the porphyrin-forming reaction involving condensation of steroidal-alkylaldehydes and pyrrole to give 5,10,15,20-tetrakis(steroidal-alkyl)porphyrins and differ in the way in which the required aldehyde is introduced to the steroidal component. In the other strategy, a steroidal component is introduced by post-porphyrin synthesis reactions and here also two approaches were explored, one involving nucleophilic substitution and the other esterification. Of the four approaches investigated, the most efficient and most versatile one attaches the steroidal components late in the sequence to a 5,10,15,20-tetra(ω-haloalkyl)porphyrin by a nucleophilic substitution reaction. In this way, a 5,10,15,20-tetrakis[oestrone-linked-heptyl)porphyrin was obtained in 47 % yield.

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