Gene profiling of the FXR agonist fexaramine in human cultured hepatocytes

2013 ◽  
Author(s):  
M Downes
Keyword(s):  
Gene Profiling ◽  
Cultured Hepatocytes

1841: Characterization of the Development of Chronic Allograft Nephropathy (CAN) by Gene Profiling- Effects of Isotretinoin (IT)

2004 ◽  
Vol 171 (4S) ◽  
pp. 486-487
Author(s):  
Judith Adams ◽  
Eva Kiss ◽  
Shijun Wang ◽  
Hermann-Josef Groene ◽  
Markus Hohenfellner
Keyword(s):  
Chronic Allograft Nephropathy ◽  
Gene Profiling

NLRP3 inflammasome expression in cultured hepatocytes is regulated by nuclear factor-κB (NF-κB)

2015 ◽  
Vol 53 (01) ◽  
Author(s):  
SG Boaru ◽  
E Borkham-Kamphorst ◽  
E Van de Leur ◽  
C Liedtke ◽  
R Weiskirchen
Keyword(s):  
Nlrp3 Inflammasome ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Cultured Hepatocytes

scholarly journals Phenylalanine Hydroxylase in Cultured Hepatocytes

1973 ◽  
Vol 248 (1) ◽  
pp. 223-232
Author(s):  
Donald F. Haggerty ◽  
Peggy L. Young ◽  
G. Popják ◽  
William H. Carnes
Keyword(s):  
Phenylalanine Hydroxylase ◽  
Cultured Hepatocytes

scholarly journals Single-Oocyte Gene Expression Suggests That Curcumin Can Protect the Ovarian Reserve by Regulating the PTEN-AKT-FOXO3a Pathway

2021 ◽  
Vol 22 (12) ◽  
pp. 6570
Author(s):  
Yue Lv ◽  
Rui-Can Cao ◽  
Hong-Bin Liu ◽  
Xian-Wei Su ◽  
Gang Lu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ovarian Reserve ◽  
Primordial Follicle ◽  
Term Treatment ◽  
New Drugs ◽  
Gene Profiling ◽  
Primordial Follicles ◽  
Long Term Treatment ◽  
Follicle Activation

A better understanding of the mechanism of primordial follicle activation will help us better understand the causes of premature ovarian insufficiency (POI), and will help us identify new drugs that can be applied to the clinical treatment of infertility. In this study, single oocytes were isolated from primordial and primary follicles, and were used for gene profiling with TaqMan array cards. Bioinformatics analysis was performed on the gene expression data, and Ingenuity Pathway Analysis was used to analyze and predict drugs that affect follicle activation. An ovarian in vitro culture system was used to verify the function of the drug candidates, and we found that curcumin maintains the ovarian reserve. Long-term treatment with 100 mg/kg curcumin improved the ovarian reserve indicators of AMH, FSH, and estradiol in aging mice. Mechanistic studies show that curcumin can affect the translocation of FOXO3, thereby inhibiting the PTEN-AKT-FOXO3a pathway and protecting primordial follicles from overactivation. These results suggest that curcumin is a potential drug for the treatment of POI patients and for fertility preservation.

scholarly journals Increase in surface expression of transferrin receptors on cultured hepatocytes of adult rats in response to iron deficiency.

1988 ◽  
Vol 263 (29) ◽  
pp. 14753-14756
Author(s):  
U Muller-Eberhard ◽  
H H Liem ◽  
J A Grasso ◽  
S Giffhorn-Katz ◽  
M G DeFalco ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Surface Expression ◽  
Transferrin Receptors ◽  
Cultured Hepatocytes ◽  
Adult Rats
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