Analysis of the fibroblast growth factor receptor 1 (Fgfr1)-dependent transcriptome in mouse mammary gland

2019 ◽  
Author(s):  
KL Schwertfeger
Keyword(s):  
Mammary Gland ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Mouse Mammary Gland ◽  
Fibroblast Growth

Fibroblast growth factor receptor signalling has a role in lobuloalveolar development of the mammary gland

1997 ◽  
Vol 110 (11) ◽  
pp. 1261-1268 ◽  
Author(s):  
D. Jackson ◽  
J. Bresnick ◽  
I. Rosewell ◽  
T. Crafton ◽  
R. Poulsom ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Post Partum ◽  
Growth Factor Receptor ◽  
Mammary Epithelium ◽  
Dominant Negative ◽  
Fibroblast Growth ◽  
Lobuloalveolar Development

We have used the mouse mammary tumor virus promoter to express two dominant negative (DN) fibroblast growth factor receptor (FGFR) isoforms in the mammary epithelium of transgenic mice. While expression of DN-FGFR1(IIIc) showed no discernible phenotype, a similar kinase negative form of FGFR2(IIIb) caused a marked impairment of lobuloalveolar development. The growth retardation was apparent by mid-pregnancy and persisted in the post-partum glands. Despite the substantial underdevelopment of the mammary gland there was a measurable lactational response, but it was insufficient to properly sustain the new-born pups. These findings demonstrate that fibroblast growth factor signalling is necessary for pregnancy dependent lobuloalveolar development of the mammary gland.

Fibroblast Growth Factor Receptor Inhibitors

2012 ◽  
Vol 19 (4) ◽  
pp. 687-701
Author(s):  
Suneel Kumar B.V.S ◽  
Lakshmi Narasu ◽  
Rambabu Gundla ◽  
Raveendra Dayam ◽  
Sarma J.A.R.P
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth

Enhanced Expression of Fibroblast Growth Factor Receptor 3 in Human Skin Cancer Cells

2009 ◽  
Vol 2 (1) ◽  
pp. 30-36 ◽  
Author(s):  
Motoki Terada ◽  
Chikara Ohnishi ◽  
Nobuhiro Ueno ◽  
Akio Shimizu ◽  
Michiyuki Kanai ◽  
...  
Keyword(s):  
Growth Factor ◽  
Skin Cancer ◽  
Cancer Cells ◽  
Fibroblast Growth Factor ◽  
Human Skin ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth ◽  
Enhanced Expression
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