scholarly journals Fine Structure of the Reticuloendothelial System in the Spleen with Special Reference to the Red Pulp

1967 ◽  
Vol 91 (4) ◽  
pp. 367-374 ◽  
Author(s):  
Takeo Yamori ◽  
Yoshitaka Mori
Keyword(s):  
Fine Structure ◽  
Special Reference ◽  
Reticuloendothelial System ◽  
Red Pulp

scholarly journals Splenic Mechanisms of Thrombocytopenia

Blood ◽  
2017 ◽  
Vol 130 (Suppl_1) ◽  
pp. SCI-33-SCI-33
Author(s):  
John W. Semple
Keyword(s):  
Immune Responses ◽  
Reticuloendothelial System ◽  
Lymphoid Organ ◽  
The Body ◽  
White Pulp ◽  
Cellular Mechanisms ◽  
Venous Circulation ◽  
Destructive Processes ◽  
Clinical Conditions ◽  
Red Pulp

The spleen is the largest secondary lymphoid organ in the body and contains up to 25 percent of the body's lymphocyte populations. It is not only responsible for initiating immune responses against a multitude of infectious antigens within its white pulp, it also has the exquisite ability to filter the blood and remove, for example, senescent erythrocytes and platelets. This natural process is carried out within the red pulp of the spleen which is composed monocyte-rich connective tissue cords of Billroth intertwined with sinus cavities lined by parallel-oriented endothelial cells that have interendothelial slits which allow for the mechanical sorting of "old" cells. This occurs because of the inability of the senescent cells to properly migrate through the endothelial fenestrae into the venous circulation allowing them to be identified by cells of the reticuloendothelial system (RES) and quickly destroyed by phagocytosis. This process also allows for the efficient recycling of iron from destroyed erythrocyte hemoglobin molecules. There are a wide variety of clinical conditions that can significantly alter the ability of the RES to destroy blood cells including hereditary blood cell defects, inflammation, cancer and abnormal immune responses. This lecture will focus on the central role that the spleen plays in not only generating immune responses against platelets but also in primarily causing the destruction of both senescent and antibody-opsonized platelets leading to thrombocytopenia. It will discuss the soluble and cellular mechanisms of splenic sequestration, destruction and the ability of the spleen to modulate anti-platelet immunity. Mechanisms involving complement activation, Fc Receptor-mediated phagocytosis, antibody dependent cellular cytotoxicity and platelet self-destruction will be addressed. It will compare the spleen's platelet destructive capabilities with other organs, particularly the liver and will detail how immune responses generated in the white pulp can modulate platelet destructive processes in the red pulp. Disclosures Semple: Amgen: Consultancy, Honoraria, Speakers Bureau; Rigel: Consultancy, Honoraria; UCB: Consultancy, Honoraria.

Fine structure of prolactin pituitary adenoma with special reference to annulate lamellae

1979 ◽  
Vol 46 (1-2) ◽  
pp. 163-166 ◽  
Author(s):  
M. Scanarini ◽  
R. Giordano ◽  
S. Mingrino ◽  
N. Pennelli
Keyword(s):  
Fine Structure ◽  
Pituitary Adenoma ◽  
Special Reference ◽  
Annulate Lamellae

A Discussion on solar studies with special reference to space observations - The manifold structure of the chromosphere and corona

1971 ◽  
Vol 270 (1202) ◽  
pp. 77-80 ◽  
Keyword(s):  
Magnetic Field ◽  
Fine Structure ◽  
High Resolution ◽  
Field Strength ◽  
Special Reference ◽  
Velocity Fields ◽  
Field Patterns ◽  
Uniform Region ◽  
Determining Factor ◽  
The Magnetic Field

Although the photosphere is a uniform region for scales greater than the granulation, the fact that the magnetic field strength falls off less sharply than the gas pressure leads to strong magnetic influence at greater heights in the solar atmosphere. This magnetic influence leads to non-uniformity and fine structure in the chromosphere and corona. The existence of such structure has been deduced mostly from measurements of photospheric phenomena; in particular, from measurements of photospheric velocity fields (Leighton, Noyes & Simon 1962) and of photospheric magnetic fields (Bumba & Howard 1965). The determining factor would thus appear to be in the photosphere; but visible effects only are produced in the chromosphere and corona. In recent years, high resolution filter photography has enabled us to recognize different regions of the chromosphere, where qualitatively different structure is associated with distinct magnetic field patterns. This progress has been possible because of better Lyot filters, better films and better observing sites; the spectroheliograph has always been limited for high resolution work by the finite slit width and the difficulty of accurate guiding during the long exposures.

Morphological study of noradrenaline innervation in the caudal raphe nuclei with special reference to fine structure

1981 ◽  
Vol 203 (1) ◽  
pp. 15-22 ◽  
Author(s):  
Hiroshi Takagi ◽  
Kazumi Yamamoto ◽  
Sadao Shiosaka ◽  
Emiko Senba ◽  
Kenichi Takatsuki ◽  
...  
Keyword(s):  
Fine Structure ◽  
Special Reference ◽  
Morphological Study ◽  
Raphe Nuclei ◽  
Raphé Nuclei
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