scholarly journals The FOXL2 Mutation (c.402C^|^gt;G) in Adult-Type Ovarian Granulosa Cell Tumors of Three Japanese Patients: Clinical Report and Review of the Literature

2013 ◽  
Vol 231 (4) ◽  
pp. 243-250 ◽  
Author(s):  
Akimasa Takahashi ◽  
Fuminori Kimura ◽  
Akiyoshi Yamanaka ◽  
Akie Takebayashi ◽  
Nobuyuki Kita ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Japanese Patients ◽  
Clinical Report ◽  
Review Of The Literature ◽  
Adult Type ◽  
Granulosa Cell Tumors ◽  
Ovarian Granulosa Cell

scholarly journals Characteristics and outcome of recurrence in molecularly defined adult-type ovarian granulosa cell tumors

2016 ◽  
Vol 143 (3) ◽  
pp. 571-577 ◽  
Author(s):  
Saara Bryk ◽  
Anniina Färkkilä ◽  
Ralf Bützow ◽  
Arto Leminen ◽  
Johanna Tapper ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Adult Type ◽  
Granulosa Cell Tumors ◽  
Ovarian Granulosa Cell

scholarly journals Ovarian granulosa cell tumors: a retrospective study of 27 cases and a review of the literature

2013 ◽  
Vol 11 (1) ◽  
Author(s):  
Sakina Sekkate ◽  
Mouna Kairouani ◽  
Badr Serji ◽  
Adnane Tazi ◽  
Hind Mrabti ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Granulosa Cell ◽  
Review Of The Literature ◽  
Granulosa Cell Tumors ◽  
Ovarian Granulosa Cell

scholarly journals Adult type granulosa cell tumor in adult testis: report of a case and review of the literature

Rare Tumors ◽  
2011 ◽  
Vol 3 (4) ◽  
pp. 117-119 ◽  
Author(s):  
Zhao Song ◽  
David J. Vaughn ◽  
Zhanyong Bing
Keyword(s):  
Alkaline Phosphatase ◽  
Granulosa Cell ◽  
Epithelial Membrane Antigen ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Review Of The Literature ◽  
Adult Type ◽  
Adult Testis ◽  
Granulosa Cell Tumors ◽  
Hmb 45

Granulosa cell tumors can be classified into juvenile and adult types and more commonly occur in ovaries. Adult testicular granulosa cell tumors are extremely rare and only 29 cases of adult type have previously been reported. We report here a 28-year old Caucasian man with a left testicular adult type granulosa cell tumor. The tumor measured 2.6×2.6×2.5 cm and was mitotically active (10/10 HPF). Immunohistochemical stains showed the tumor diffusely positive for inhibin and vimentin, and negative for epithelial membrane antigen, cytokeratins, synaptophysin, HMB-45, OCT-4, placental-like alkaline phosphatase and lymphoid markers. The reported granulosa cell tumors in adult testis were briefly reviewed.

Assessment of predictive biomarker prevalence in molecularly defined adult-type ovarian granulosa cell tumors.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 5567-5567
Author(s):  
Robert Tyler Hillman ◽  
Douglas I. Lin ◽  
David Marc Gershenson
Keyword(s):  
Microsatellite Instability ◽  
Granulosa Cell ◽  
Predictive Biomarkers ◽  
Cross Sectional Study ◽  
Adult Type ◽  
Cross Sectional ◽  
Granulosa Cell Tumors ◽  
Mutational Burden ◽  
Ovarian Granulosa Cell ◽  
Tumor Mutational Burden

5567 Background: The FDA has separately approved pembrolizumab for all advanced solid tumors with either microsatellite instability or high tumor mutational burden (≥10 mutations per megabase), and homologous recombination deficiency is an established biomarker for response to poly ADP ribose polymerase inhibitors in epithelial ovarian cancer. The detection of these predictive biomarkers in adult-type ovarian granulosa cell tumors could identify novel treatment strategies in this rare disease. The primary objective of this study was to determine the prevalence of established predictive biomarkers among molecularly defined adult-type ovarian granulosa cell tumors. Methods: With institutional review board approval, we performed a cross-sectional study examining de-identified FoundationOne companion diagnostic molecular profiles for 423 women with molecularly defined (FOXL2 c.C402G positive) adult type ovarian granulosa cell tumors. The dataset was comprised of coding variants for up to 406 genes as well as genomic signatures including microsatellite instability, tumor mutational burden, and genome wide loss of heterozygosity. PD-L1 expression by immunohistochemistry was also available for a subset of tumors. Descriptive statistics were used for comparison between groups and all statistical tests were two-sided. Results: Women in this cohort had a mean age of 57 years (range 24-87) at the time of sample submission for molecular profiling. The median tumor mutational burden was 1.3 mutations per megabase [mut/Mb] (range 0-8.8 mut/Mb). TP53-mutated aGCT had a higher tumor mutation burden than TP53 non-mutated tumors (median 2.4 mut/Mb, 95% CI 1.7-3.0 mut/Mb vs median 1.3 mut/Mb, 95% CI 1.5-1.9 mut/Mb; P=.02). All 384 tumors with available microsatellite instability testing were microsatellite stable. Sixty-seven tumors had PD-L1 expression measured and of these 94% (63/67) were negative with the remainder “low positive.” No tumors were positive for genome wide loss of heterozygosity. Apart from FOXL2 c.C402G, the most frequent short variants were TERT promoter mutations (-124C>T: 190/423, 45.0%; -146C>T: 39/423, 9.2%). Other frequently observed variants included truncating mutations in KMT2D/MLL2 (71/423, 16.8%), pathogenic TP53 mutations (35/423, 8.3%), CDKN2A/B deletions (43/423, 10.2%), and activating PIK3CA mutations (23/423, 5.4%). Conclusions: No women with molecularly defined adult-type ovarian granulosa cell tumors in this large cross-sectional study would be eligible for FDA-approved pembrolizumab based on either microsatellite instability or high tumor mutational burden. No tumors exhibited evidence of homologous recombination deficiency and molecularly targetable mutations were rare. The development of novel precision treatment options remains a critical unmet need for this rare disease.

A long-term follow-up study of 176 cases with adult-type ovarian granulosa cell tumors

2012 ◽  
Vol 124 (2) ◽  
pp. 244-249 ◽  
Author(s):  
Hsu-Dong Sun ◽  
Hao Lin ◽  
Mei-Shan Jao ◽  
Kung-Liahng Wang ◽  
Wen-Shiung Liou ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Adult Type ◽  
Follow Up Study ◽  
Granulosa Cell Tumors ◽  
Ovarian Granulosa Cell ◽  
Long Term Follow Up

Ovarian granulosa cell tumors frequently express EGFR (Her-1), Her-3, and Her-4: An immunohistochemical study

2006 ◽  
Vol 101 (1) ◽  
pp. 18-23 ◽  
Author(s):  
Sebastian Leibl ◽  
Koppany Bodo ◽  
Margit Gogg-Kammerer ◽  
Andelko Hrzenjak ◽  
Edgar Petru ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Immunohistochemical Study ◽  
Granulosa Cell Tumors ◽  
Ovarian Granulosa Cell
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