scholarly journals Treatment with L-Valine Ameliorates Liver Fibrosis and Restores Thrombopoiesis in Rats Exposed to Carbon Tetrachloride

2010 ◽  
Vol 221 (2) ◽  
pp. 151-159 ◽  
Author(s):  
Chikashi Nakanishi ◽  
Hideyuki Doi ◽  
Kazunori Katsura ◽  
Susumu Satomi
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Fibrosis

Protective effect of mixture of Aloe and Silybum on carbon tetrachloride-induced acute hepatotoxicity and liver fibrosis

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
YJ Moon ◽  
WC Lee ◽  
SJ Kim ◽  
ST Oh ◽  
EJ Shin ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Fibrosis ◽  
Protective Effect

scholarly journals Increased procollagen mRNA levels in carbon tetrachloride-induced liver fibrosis in rats.

1987 ◽  
Vol 262 (4) ◽  
pp. 1652-1658
Author(s):  
R A Pierce ◽  
M R Glaug ◽  
R S Greco ◽  
J W Mackenzie ◽  
C D Boyd ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Fibrosis ◽  
Mrna Levels

Chinese medicine CGA formula ameliorates liver fibrosis induced by carbon tetrachloride involving inhibition of hepatic apoptosis in rats

2019 ◽  
Vol 232 ◽  
pp. 227-235 ◽  
Author(s):  
Huajie Tian ◽  
Lin Liu ◽  
Zhixiong Li ◽  
Wei Liu ◽  
Zhaolin Sun ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Carbon Tetrachloride ◽  
Liver Fibrosis

scholarly journals Protective Effect of a Mixture of Aloe vera and Silybum marianum Against Carbon Tetrachloride–Induced Acute Hepatotoxicity and Liver Fibrosis

2009 ◽  
Vol 109 (1) ◽  
pp. 119-127 ◽  
Author(s):  
Sung-Hwa Kim ◽  
Ho Jun Cheon ◽  
Nari Yun ◽  
Sun-Tack Oh ◽  
Eunju Shin ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Fibrosis ◽  
Protective Effect ◽  
Aloe Vera ◽  
Silybum Marianum

scholarly journals Protection Effect of Kallistatin on Carbon Tetrachloride-Induced Liver Fibrosis in Rats via Antioxidative Stress

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e88498 ◽  
Author(s):  
Xiaoping Huang ◽  
Xiao Wang ◽  
Yinghui Lv ◽  
Luli Xu ◽  
Junsheng Lin ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Fibrosis ◽  
Protection Effect ◽  
Antioxidative Stress

scholarly journals Identification of GDF15 as A Pro-Fibrotic Factor in Mouse Liver Fibrosis Progression

2021 ◽  
Author(s):  
Peng Qi ◽  
Ming-Ze Ma ◽  
Jing-Hua Kuai
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Fibrosis ◽  
Hepatic Stellate Cell ◽  
Hepatic Stellate Cells ◽  
Liver Tissue ◽  
Cell Activation ◽  
Stellate Cell ◽  
Neutralizing Antibody ◽  
Stellate Cells ◽  
Fibrosis Progression

Abstract Aim:To elucidate the inhibitory role of growth differentiation factor 15 (GDF15) in liver fibrosis and its possible activation mechanism in hepatic stellate cells of mice.Methods:We generated a GDF15-neutralizing antibody that can inhibit TGF-β1-induced activation of the TGF-β/Smad2/3 pathway in LX-2 cells. All the mice in this study were induced by carbon tetrachloride and thioacetamide. In addition, primary hepatic stellate cells from mice were isolated from fresh livers using Nycodenz density gradient separation. The severity and extent of liver fibrosis in mice were evaluated by Sirius Red and Masson staining. The effect of GDF15 on the activation of the TGF-β pathway was detected using dual-luciferase reporter assays and Western blotting assays.Results:The expression of GDF15 in cirrhotic liver tissue was higher than that in normal liver tissue. Blocking GDF15 with a neutralizing antibody resulted in a delay in primary hepatic stellate cell activation and remission of liver fibrosis induced by carbon tetrachloride or thioacetamide. Meanwhile, TGF-β pathway activation was partly inhibited by a GDF15-neutralizing antibody in primary hepatic stellate cells. These results indicated that GDF15 plays an important role in regulating HSC activation and liver fibrosis progression.Conclusions:The inhibition of GDF15 attenuates chemical-inducible liver fibrosis and delays hepatic stellate cell activation, and this effect is probably mainly attributed to its regulatory role in TGF-β signalling.

scholarly journals Suppression of Carbon Tetrachloride-Induced Liver Fibrosis by Transplantation of a Clonal Mesenchymal Stem Cell Line Derived from Rat Bone Marrow

2009 ◽  
Vol 18 (1) ◽  
pp. 89-100 ◽  
Author(s):  
Marhaen Hardjo ◽  
Masahiro Miyazaki ◽  
Masakiyo Sakaguchi ◽  
Takuro Masaka ◽  
Sukaeni Ibrahim ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Carbon Tetrachloride ◽  
Liver Fibrosis ◽  
Mesenchymal Stem Cell ◽  
Cell Line ◽  
Stem Cell Line ◽  
Rat Bone
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