scholarly journals Effect of Dose-Rate and Lung Dose in Total Body Irradiation on Interstitial Pneumonitis after Bone Marrow Transplantation

2004 ◽  
Vol 202 (4) ◽  
pp. 255-263 ◽  
Author(s):  
Murat Beyzadeoglu ◽  
Kaan Oysul ◽  
Bahar Dirican ◽  
Fikret Arpaci ◽  
Arzu Balkan ◽  
...  
Blood ◽  
1984 ◽  
Vol 64 (4) ◽  
pp. 852-857
Author(s):  
R Parkman ◽  
JM Rappeport ◽  
S Hellman ◽  
J Lipton ◽  
B Smith ◽  
...  

The capacity of busulfan and total body irradiation to ablate hematopoietic stem cells as preparation for the allogeneic bone marrow transplantation of patients with congenital bone marrow disorders was studied. Fourteen patients received 18 transplants; busulfan was used in the preparatory regimen of eight transplants and total body irradiation in the regimens of six transplants. Sustained hematopoietic ablation was achieved in six of eight patients prepared with busulfan and in all six patients prepared with total body irradiation. Three patients prepared with total body irradiation died with idiopathic interstitial pneumonitis, whereas no patients receiving busulfan developed interstitial pneumonitis. The optimal antihematopoietic stem cell agent to be used for the preparation of patients with congenital bone marrow disorder for bone marrow transplantation is not certain.


Haematologia ◽  
2002 ◽  
Vol 32 (1) ◽  
pp. 25-30 ◽  
Author(s):  
Fikret Arpaci ◽  
Bahar Dirican ◽  
Murat Beyzadeoglu ◽  
Kaan Oysul ◽  
Yucel Pak

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