scholarly journals Comparative Study of Cancer Treatment Potential Effects of Tumor-Treating Fields and Cold Atmospheric Plasma

2020 ◽  
Vol 10 (1) ◽  
pp. 45-59 ◽  
Author(s):  
Xiaoliang Yao ◽  
Isaac Goldstein ◽  
Li Lin ◽  
Jonathan H. Sherman ◽  
Michael Keidar
Keyword(s):  
Comparative Study ◽  
Cancer Treatment ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma ◽  
Tumor Treating Fields

scholarly journals INNV-08. COMPARATIVE STUDY OF THE CANCER TREATMENT POTENTIAL EFFECT OF TUMOR-TREATING FIELDS AND COLD ATMOSPHERIC PLASMA

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii118-ii118
Author(s):  
Xiaoliang Yao ◽  
Isaac Goldstein ◽  
Li Lin ◽  
Jonathan Sherman ◽  
Michael Keidar
Keyword(s):  
Cell Viability ◽  
Cancer Treatment ◽  
Brain Cancer ◽  
Room Temperature ◽  
Treatment Time ◽  
In Vitro Study ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma ◽  
Tumor Treating Fields

Abstract INTRODUCTION Cold Atmospheric Plasma (CAP) is ionized gas close to room temperature that generates reactive oxygen and nitrogen species, an electromagnetic field (EMF) and UV, which are selectively cytotoxic to cancer cells. Tumor Treating Fields (TTFields) is an FDA approved cancer treatment that utilizes “low intensity” and “intermediate frequency” alternating electric fields to produce an inhibitory effect on cancerous cells. OBJECTIVES In this study, we directly compared CAP and TTFields treatments using U87 glioblastoma tumor cells. We aimed to assess the relative merits of both technologies as potential approaches for brain cancer treatment. METHODS In this in vitro study, the cells were treated with either CAP or TTFields at room temperature. In both cases in order the optimize the treatment parameters, the energy we applied was varied for both methods by changing the power and time of the treatment. The resulting cell viability changes were measured 72 hours after treatment. RESULTS The results revealed that increased energy resulted in decreased cell viability of U87 glioblastoma tumor cells with both CAP and TTFields treatment. The rate of U87 glioblastoma tumor cell viability under CAP treatment was 80% of the original viability after using 4.8J of energy, compared with 15,752J of energy with TTFields treatment. Additionally, the CAP displayed significantly greater time-efficiency as compared to TTFields. For instance, the most effective TTFields treatment took 4 hours, while the CAP treatment displayed a comparable effect on tumor cell viability with a treatment time of 30 seconds. CONCLUSIONS This preliminary in vitro study indicates that CAP treatment is potentially a more favorable effective method of brain cancer therapy. This data indicates that CAP is significantly more energy-efficient and requires significantly less treatment time than TTFields. Future research looks to compare the 2 treatments in an intracranial mouse xenograft model.

The Application of the Cold Atmospheric Plasma-Activated Solutions in Cancer Treatment

2018 ◽  
Vol 18 (6) ◽  
pp. 769-775 ◽  
Author(s):  
Dayun Yan ◽  
Jonathan H. Sherman ◽  
Michael Keidar
Keyword(s):  
Cancer Treatment ◽  
Atmospheric Plasma ◽  
Current Status ◽  
Cold Atmospheric Plasma ◽  
Anti Cancer ◽  
Long Time ◽  
Key Topics ◽  
The Common

Background: Over the past five years, the cold atmospheric plasma-activated solutions (PAS) have shown their promissing application in cancer treatment. Similar as the common direct cold plasma treatment, PAS shows a selective anti-cancer capacity in vitro and in vivo. However, different from the direct cold atmospheric plasma (CAP) treatment, PAS can be stored for a long time and can be used without dependence on a CAP device. The research on PAS is gradually becoming a hot topic in plasma medicine. Objectives: In this review, we gave a concise but comprehensive summary on key topics about PAS including the development, current status, as well as the main conclusions about the anti-cancer mechanism achieved in past years. The approaches to make strong and stable PAS are also summarized.

scholarly journals The Cell Activation Phenomena in the Cold Atmospheric Plasma Cancer Treatment

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Dayun Yan ◽  
Wenjun Xu ◽  
Xiaoliang Yao ◽  
Li Lin ◽  
Jonathan H. Sherman ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Cell Activation ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma

scholarly journals Comparative Study between Direct and Indirect Treatment with Cold Atmospheric Plasma on In Vitro and In Vivo Models of Wound Healing

2018 ◽  
Vol 8 (4) ◽  
pp. 379-401 ◽  
Author(s):  
Constance Duchesne ◽  
Nadira Frescaline ◽  
Jean-Jacques Lataillade ◽  
Antoine Rousseau
Keyword(s):  
Wound Healing ◽  
Comparative Study ◽  
Atmospheric Plasma ◽  
In Vivo Models ◽  
Cold Atmospheric Plasma ◽  
Indirect Treatment

scholarly journals Micro-Sized Cold Atmospheric Plasma Source for Brain and Breast Cancer Treatment

2018 ◽  
Vol 8 (2) ◽  
pp. 203-215 ◽  
Author(s):  
Zhitong Chen ◽  
Li Lin ◽  
Qinmin Zheng ◽  
Jonathan H. Sherman ◽  
Jerome Canady ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Plasma Source ◽  
Breast Cancer Treatment ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma

scholarly journals Principles of using Cold Atmospheric Plasma Stimulated Media for Cancer Treatment

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Dayun Yan ◽  
Annie Talbot ◽  
Niki Nourmohammadi ◽  
Xiaoqian Cheng ◽  
Jerome Canady ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma

scholarly journals Cold Atmospheric Plasma Cancer Treatment, a Critical Review

2021 ◽  
Vol 11 (16) ◽  
pp. 7757
Author(s):  
Dayun Yan ◽  
Alisa Malyavko ◽  
Qihui Wang ◽  
Li Lin ◽  
Jonathan H. Sherman ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Molecular Mechanisms ◽  
Critical Evaluation ◽  
Atmospheric Plasma ◽  
Physical Factors ◽  
Atmospheric Conditions ◽  
Cold Atmospheric Plasma ◽  
Anti Cancer ◽  
Biological Impacts ◽  
Indirect Treatment

Cold atmospheric plasma (CAP) is an ionized gas, the product of a non-equilibrium discharge at atmospheric conditions. Both chemical and physical factors in CAP have been demonstrated to have unique biological impacts in cancer treatment. From a chemical-based perspective, the anti-cancer efficacy is determined by the cellular sensitivity to reactive species. CAP may also be used as a powerful anti-cancer modality based on its physical factors, mainly EM emission. Here, we delve into three CAP cancer treatment approaches, chemically based direct/indirect treatment and physical-based treatment by discussing their basic principles, features, advantages, and drawbacks. This review does not focus on the molecular mechanisms, which have been widely introduced in previous reviews. Based on these approaches and novel adaptive plasma concepts, we discuss the potential clinical application of CAP cancer treatment using a critical evaluation and forward-looking perspectives.

scholarly journals Portable air-fed cold atmospheric plasma device for postsurgical cancer treatment

2021 ◽  
Vol 7 (36) ◽  
Author(s):  
Guojun Chen ◽  
Zhitong Chen ◽  
Zejun Wang ◽  
Richard Obenchain ◽  
Di Wen ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Atmospheric Plasma ◽  
Cold Atmospheric Plasma ◽  
Plasma Device

Mathematical modeling and control for cancer treatment with cold atmospheric plasma jet

2019 ◽  
Vol 52 (18) ◽  
pp. 185202 ◽  
Author(s):  
Yuanwei Lyu ◽  
Li Lin ◽  
Eda Gjika ◽  
Taeyoung Lee ◽  
Michael Keidar
Keyword(s):  
Mathematical Modeling ◽  
Cancer Treatment ◽  
Plasma Jet ◽  
Atmospheric Plasma ◽  
Modeling And Control ◽  
Cold Atmospheric Plasma ◽  
And Control
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