HYPERTHERMIA EFFECTS ON MACROSCOPIC FLUID TRANSPORT IN TUMORS

Author(s):  
Assunta Andreozzi ◽  
Marcello Iasiello ◽  
Paolo Netti
2008 ◽  
Vol 70 (8) ◽  
pp. 2334-2357 ◽  
Author(s):  
S. Jonathan Chapman ◽  
Rebecca J. Shipley ◽  
Rossa Jawad

Author(s):  
Assunta Andreozzi ◽  
Marcello Iasiello ◽  
Paolo Netti

2021 ◽  
Vol 11 (7) ◽  
pp. 2909
Author(s):  
Weiqing Huang ◽  
Liyi Lai ◽  
Zhenlin Chen ◽  
Xiaosheng Chen ◽  
Zhi Huang ◽  
...  

Imitating the structure of the venous valve and its characteristics of passive opening and closing with changes in heart pressure, a piezoelectric pump with flexible valves (PPFV) was designed. Firstly, the structure and the working principle of the PPFV were introduced. Then, the flexible valve, the main functional component of the pump, was analyzed theoretically. Finally, an experimental prototype was manufactured and its performance was tested. The research proves that the PPFV can achieve a smooth transition between valved and valveless by only changing the driving signal of the piezoelectric (PZT) vibrator. The results demonstrate that when the driving voltage is 100 V and the frequency is 25 Hz, the experimental flow rate of the PPFV is about 119.61 mL/min, and the output pressure is about 6.16 kPa. This kind of pump can realize the reciprocal conversion of a large flow rate, high output pressure, and a small flow rate, low output pressure under the electronic control signal. Therefore, it can be utilized for fluid transport and pressure transmission at both the macro-level and the micro-level, which belongs to the macro–micro combined component.


2021 ◽  
Vol 434 ◽  
pp. 106419
Author(s):  
E. Horstmann ◽  
Y. Tomonaga ◽  
M.S. Brennwald ◽  
M. Schmidt ◽  
V. Liebetrau ◽  
...  

1979 ◽  
Vol 19 (9) ◽  
pp. 651-659 ◽  
Author(s):  
James M. McKelvey ◽  
G. Vincent Sharps

2020 ◽  
Vol 40 (10) ◽  
pp. 1975-1986
Author(s):  
Nicholas B Bèchet ◽  
Tekla M Kylkilahti ◽  
Bengt Mattsson ◽  
Martina Petrasova ◽  
Nagesh C Shanbhag ◽  
...  

Fluid transport in the perivascular space by the glia-lymphatic (glymphatic) system is important for the removal of solutes from the brain parenchyma, including peptides such as amyloid-beta which are implicated in the pathogenesis of Alzheimer’s disease. The glymphatic system is highly active in the sleep state and under the influence of certain of anaesthetics, while it is suppressed in the awake state and by other anaesthetics. Here we investigated whether light sheet fluorescence microscopy of whole optically cleared murine brains was capable of detecting glymphatic differences in sleep- and awake-mimicking anaesthesia, respectively. Using light-sheet imaging of whole brains, we found anaesthetic-dependent cerebrospinal fluid (CSF) influx differences, including reduced tracer influx along tertiary branches of the middle cerebral artery and reduced influx along dorsal and anterior penetrating arterioles, in the awake-mimicking anaesthesia. This study establishes that light sheet microscopy of optically cleared brains is feasible for quantitative analyses and can provide images of the entire glymphatic system in whole brains.


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