scholarly journals Evaluation of the Effectiveness of Mass Trapping With BG-Sentinel Traps for Dengue Vector Control: A Cluster Randomized Controlled Trial in Manaus, Brazil

2014 ◽  
Vol 51 (2) ◽  
pp. 408-420 ◽  
Author(s):  
C. M. Degener ◽  
Á. E. Eiras ◽  
T. M. F. Ázara ◽  
R. A. Roque ◽  
S. Rösner ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Vector Control ◽  
Controlled Trial ◽  
Cluster Randomized Controlled Trial ◽  
Mass Trapping ◽  
Dengue Vector ◽  
Randomized Controlled ◽  
Cluster Randomized ◽  
Bg Sentinel ◽  
Dengue Vector Control

scholarly journals The iDEM trial (intervention for Dengue Epidemiology in Malaysia) to measure the effectiveness of integrated vector management with targeted outdoor residual spraying and autodissemination devices on the incidence of dengue in urban Malaysia: Study protocol for a cluster randomized controlled trial

2021 ◽  
Author(s):  
Mitra SAADATIAN-ELAHI ◽  
Neal Alexander ◽  
Tim Möhlmann ◽  
Carole Langlois-Jacques ◽  
Remco Suer ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Regression Model ◽  
Vector Control ◽  
Controlled Trial ◽  
Cluster Randomized Controlled Trial ◽  
Integrated Vector Management ◽  
Randomized Controlled ◽  
Vector Management ◽  
Cluster Randomized ◽  
Dengue Control

Abstract Background: In common with many South East Asian countries, Malaysia is endemic for dengue. Dengue control in Malaysia is currently based on reactive vector management within 24 hours of a dengue case being reported. Preventive rather than reactive vector control approaches, with combined interventions, are expected to improve the cost-effectiveness of dengue control programs. The principal objective of this cluster randomized controlled trial is to quantify the effectiveness of a preventive integrated vector management (IVM) strategy on the incidence of dengue as compared to routine vector control efforts. Methods: The trial is conducted in randomly allocated low and medium cost clusters located in the Federal Territory of Kuala Lumpur and Putrajaya. The IVM approach combines: targeted outdoor residual spraying with K-Othrine Polyzone, deployment of mosquito traps as auto-dissemination devices, and community engagement activities. The trial includes 280 clusters randomly allocated in a 1:1 ratio. The clusters receive either the preventive IVM in addition to the routine vector control activities, or the routine vector control activities only. Epidemiological data from monthly confirmed dengue cases during the study period will be obtained from the Vector Borne Disease Sector, Malaysian Ministry of Health e-Dengue surveillance system. Entomological surveillance data will be collected in 12 clusters randomly selected from each arm. To measure the effectiveness of the IVM approach on dengue incidence, a negative binomial regression model will be used to compare the incidence between control and intervention clusters. To quantify the effect of the interventions on the main entomological outcome, ovitrap index, a modified ordinary least squares regression model using a robust standard error estimator will be used. Discussion: Considering the ongoing expansion of dengue burden in Malaysia, setting up proactive control strategies is critical. Despite some limitations of the trial such as the use of passive surveillance to identify cases the results will be informative for a better understanding of effectiveness of proactive IVM approach in the control of dengue. Evidence from this trial may help justify investment in preventive IVM approaches as preferred to reactive case management strategies. Trial registration: ISRCTN, ISRCTN81915073, retrospectively registered on 17 April 2020 (https://doi.org/10.1186/ISRCTN81915073)

scholarly journals Measuring the effectiveness of integrated vector management with targeted outdoor residual spraying and autodissemination devices on the incidence of dengue in urban Malaysia in the iDEM trial (intervention for Dengue Epidemiology in Malaysia): study protocol for a cluster randomized controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Mitra Saadatian-Elahi ◽  
Neal Alexander ◽  
Tim Möhlmann ◽  
Carole Langlois-Jacques ◽  
Remco Suer ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Regression Model ◽  
Vector Control ◽  
Controlled Trial ◽  
Cluster Randomized Controlled Trial ◽  
Integrated Vector Management ◽  
Randomized Controlled ◽  
Vector Management ◽  
Cluster Randomized ◽  
Dengue Control

Abstract Background In common with many South East Asian countries, Malaysia is endemic for dengue. Dengue control in Malaysia is currently based on reactive vector management within 24 h of a dengue case being reported. Preventive rather than reactive vector control approaches, with combined interventions, are expected to improve the cost-effectiveness of dengue control programs. The principal objective of this cluster randomized controlled trial is to quantify the effectiveness of a preventive integrated vector management (IVM) strategy on the incidence of dengue as compared to routine vector control efforts. Methods The trial is conducted in randomly allocated clusters of low- and medium-cost housing located in the Federal Territory of Kuala Lumpur and Putrajaya. The IVM approach combines: targeted outdoor residual spraying with K-Othrine Polyzone, deployment of mosquito traps as auto-dissemination devices, and community engagement activities. The trial includes 300 clusters randomly allocated in a 1:1 ratio. The clusters receive either the preventive IVM in addition to the routine vector control activities or the routine vector control activities only. Epidemiological data from monthly confirmed dengue cases during the study period will be obtained from the Vector Borne Disease Sector, Malaysian Ministry of Health e-Dengue surveillance system. Entomological surveillance data will be collected in 12 clusters randomly selected from each arm. To measure the effectiveness of the IVM approach on dengue incidence, a negative binomial regression model will be used to compare the incidence between control and intervention clusters. To quantify the effect of the interventions on the main entomological outcome, ovitrap index, a modified ordinary least squares regression model using a robust standard error estimator will be used. Discussion Considering the ongoing expansion of dengue burden in Malaysia, setting up proactive control strategies is critical. Despite some limitations of the trial such as the use of passive surveillance to identify cases, the results will be informative for a better understanding of effectiveness of proactive IVM approach in the control of dengue. Evidence from this trial may help justify investment in preventive IVM approaches as preferred to reactive case management strategies. Trial registration ISRCTN ISRCTN81915073. Retrospectively registered on 17 April 2020.

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