Viral genetics as a critical factor to control the infection and dissemination of yellow fever virus inAedes aegypti

2016 ◽  
Author(s):  
Yan-Jang Scott Huang
Keyword(s):  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Critical Factor ◽  
Fever Virus ◽  
Viral Genetics

scholarly journals Role of the yellow fever virus structural protein genes in viral dissemination from the Aedes aegypti mosquito midgut

2006 ◽  
Vol 87 (10) ◽  
pp. 2993-3001 ◽  
Author(s):  
Kate L. McElroy ◽  
Konstantin A. Tsetsarkin ◽  
Dana L. Vanlandingham ◽  
Stephen Higgs
Keyword(s):  
Aedes Aegypti ◽  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Fever Virus ◽  
Structural Protein ◽  
Viral Genetics ◽  
Mosquito Midgut ◽  
Infectious Clones ◽  
Domain Iii

Live-attenuated virus vaccines are key components in controlling arboviral diseases, but they must not disseminate in or be transmitted by mosquito vectors. Although the cycles in which many mosquito-borne viruses are transmitted are well understood, the role of viral genetics in these processes has not been fully elucidated. Yellow fever virus (YFV) is an important arbovirus and the prototype member of the family Flaviviridae. Here, YFV was used in Aedes aegypti mosquitoes as a model to investigate the genetic basis of infection and dissemination in mosquitoes. Viruses derived from infectious clones and chimeric viruses with defined sequential manipulations were used to investigate the influence of specific sequences within the membrane and envelope structural protein genes on dissemination of virus from the mosquito midgut. Substitution of domain III of the envelope protein from a midgut-restricted YFV into a wild-type YFV resulted in a marked decrease in virus dissemination, suggesting an important role for domain III in this process. However, synergism between elements within the flavivirus structural and non-structural protein genes may be necessary for efficient virus escape from the mosquito midgut.

scholarly journals Yellow fever virus outbreak in Brazil under current and future climate

2021 ◽  
Vol 6 ◽  
pp. 664-677
Author(s):  
Tara Sadeghieh ◽  
Jan M. Sargeant ◽  
Amy L. Greer ◽  
Olaf Berke ◽  
Guillaume Dueymes ◽  
...  
Keyword(s):  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Fever Virus ◽  
Future Climate

scholarly journals Yellow Fever Outbreak in Eastern Senegal, 2020–2021

Viruses ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1475
Author(s):  
Moussa Moïse Diagne ◽  
Marie Henriette Dior Ndione ◽  
Alioune Gaye ◽  
Mamadou Aliou Barry ◽  
Diawo Diallo ◽  
...  
Keyword(s):  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Mosquito Species ◽  
Virus Transmission ◽  
Genomic Analysis ◽  
Hemorrhagic Fever ◽  
Fever Virus ◽  
World Health ◽  
Effective Vaccine ◽  
Ministry Of Health

Yellow fever virus remains a major threat in low resource countries in South America and Africa despite the existence of an effective vaccine. In Senegal and particularly in the eastern part of the country, periodic sylvatic circulation has been demonstrated with varying degrees of impact on populations in perpetual renewal. We report an outbreak that occurred from October 2020 to February 2021 in eastern Senegal, notified and managed through the synergistic effort yellow fever national surveillance implemented by the Senegalese Ministry of Health in collaboration with the World Health Organization, the countrywide 4S network set up by the Ministry of Health, the Institut Pasteur de Dakar, and the surveillance of arboviruses and hemorrhagic fever viruses in human and vector populations implemented since mid 2020 in eastern Senegal. Virological analyses highlighted the implication of sylvatic mosquito species in virus transmission. Genomic analysis showed a close relationship between the circulating strain in eastern Senegal, 2020, and another one from the West African lineage previously detected and sequenced two years ago from an unvaccinated Dutch traveler who visited the Gambia and Senegal before developing signs after returning to Europe. Moreover, genome analysis identified a 6-nucleotide deletion in the variable domain of the 3′UTR with potential impact on the biology of the viral strain that merits further investigations. Integrated surveillance of yellow fever virus but also of other arboviruses of public health interest is crucial in an ecosystem such as eastern Senegal.

YELLOW FEVER VIRUS

1929 ◽  
Vol 92 (7) ◽  
pp. 550 ◽  
Author(s):  
HENRIQUE DE BEAUREPAIRE ARAGÃO
Keyword(s):  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Fever Virus

Complete nucleotide sequence of yellow fever virus vaccine strains 17DD and 17D-213

1995 ◽  
Vol 35 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Claudia N. Duarte dos Santos ◽  
Paulo R. Post ◽  
Ricardo Carvalho ◽  
Idevaldo I. Ferreira ◽  
Charles M. Rice ◽  
...  
Keyword(s):  
Nucleotide Sequence ◽  
Yellow Fever ◽  
Virus Vaccine ◽  
Complete Nucleotide Sequence ◽  
Yellow Fever Virus ◽  
Fever Virus

Isolation of Yellow Fever Virus from Nulliparous Haemagogus (Haemagogus) janthinomys in Eastern Amazonia

2002 ◽  
Vol 2 (1) ◽  
pp. 47-50 ◽  
Author(s):  
B. Mondet ◽  
P.F.C. Vasconcelos ◽  
A.P.A. Travassos da Rosa ◽  
E.S. Travassos da Rosa ◽  
S.G. Rodrigues ◽  
...  
Keyword(s):  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Fever Virus

scholarly journals A DNA Vaccine against Yellow Fever Virus: Development and Evaluation

2015 ◽  
Vol 9 (4) ◽  
pp. e0003693 ◽  
Author(s):  
Milton Maciel ◽  
Fábia da Silva Pereira Cruz ◽  
Marli Tenório Cordeiro ◽  
Márcia Archer da Motta ◽  
Klécia Marília Soares de Melo Cassemiro ◽  
...  
Keyword(s):  
Dna Vaccine ◽  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Fever Virus

scholarly journals Using next generation sequencing to identify yellow fever virus in Uganda

Virology ◽  
2012 ◽  
Vol 422 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Laura K. McMullan ◽  
Mike Frace ◽  
Scott A. Sammons ◽  
Trevor Shoemaker ◽  
Stephen Balinandi ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Fever Virus ◽  
Next Generation ◽  
Generation Sequencing
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