Isoclast™ Active broad spectrum sap-feeding insecticide: Understanding of the mode of action and implications for resistance management

2016 ◽  
Author(s):  
Michael C. Shaw
Keyword(s):  
Broad Spectrum ◽  
Mode Of Action ◽  
Resistance Management ◽  
Sap Feeding

scholarly journals Managing Insecticide and Miticide Resistance in Florida Landscapes

EDIS ◽  
2007 ◽  
Vol 2007 (19) ◽  
Author(s):  
Eileen A. Buss ◽  
James F. Price ◽  
Elzie McCord ◽  
Curtis Nagle
Keyword(s):  
Mode Of Action ◽  
Management Practices ◽  
Resistance Management ◽  
Resistance Development ◽  
Fact Sheet ◽  
Development And Management

ENY-824, a 10-page fact sheet by Eileen A. Buss, James F. Price, Elzie McCord, and Curtis Nagle, encourages landscape managers in Florida to implement resistance management practices. It provides definitions, discussions of resistance development and management, and the use of mixtures, rotations, and mosaics as strategies. Includes references and tables showing the mode of action of insecticides and miticides. Published by the UF Department of Entomology and Nematology, July 2007. ENY-842/IN714: Managing Insecticide and Miticide Resistance in Florida Landscapes (ufl.edu)

Broad Spectrum and Mode of Action of an Antibiotic Produced by Scytonema sp. TISTR 8208 in a Seaweed-Type Bioreactor

1998 ◽  
pp. 249-256
Author(s):  
Aparat Chetsumon ◽  
Fusako Umeda ◽  
Isamu Maeda ◽  
Kiyohito Yagi ◽  
Tadashi Mizoguchi ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Mode Of Action

scholarly journals Mode-of-Action of Antimicrobial Peptides: Membrane Disruption vs. Intracellular Mechanisms

2020 ◽  
Vol 2 ◽  
Author(s):  
Aurélie H. Benfield ◽  
Sónia Troeira Henriques
Keyword(s):  
Antimicrobial Peptides ◽  
Physicochemical Properties ◽  
Broad Spectrum ◽  
Mode Of Action ◽  
Bacterial Pathogens ◽  
Model Membranes ◽  
Membrane Disruption ◽  
Attractive Alternative ◽  
Bacterial Cells

Antimicrobial peptides are an attractive alternative to traditional antibiotics, due to their physicochemical properties, activity toward a broad spectrum of bacteria, and mode-of-actions distinct from those used by current antibiotics. In general, antimicrobial peptides kill bacteria by either disrupting their membrane, or by entering inside bacterial cells to interact with intracellular components. Characterization of their mode-of-action is essential to improve their activity, avoid resistance in bacterial pathogens, and accelerate their use as therapeutics. Here we review experimental biophysical tools that can be employed with model membranes and bacterial cells to characterize the mode-of-action of antimicrobial peptides.

scholarly journals Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the γ-glutamyl cycle as a proton sink

2016 ◽  
Vol 113 (6) ◽  
pp. 1630-1635 ◽  
Author(s):  
Maxwell Z. Wilson ◽  
Rurun Wang ◽  
Zemer Gitai ◽  
Mohammad R. Seyedsayamdost
Keyword(s):  
Broad Spectrum ◽  
Marine Bacteria ◽  
Anticancer Agents ◽  
Mode Of Action ◽  
Resistance Mechanism ◽  
Acid Resistance ◽  
Structural Features ◽  
Anticancer Activities ◽  
Tropodithietic Acid ◽  
Biochemical Analyses

While we have come to appreciate the architectural complexity of microbially synthesized secondary metabolites, far less attention has been paid to linking their structural features with possible modes of action. This is certainly the case with tropodithietic acid (TDA), a broad-spectrum antibiotic generated by marine bacteria that engage in dynamic symbioses with microscopic algae. TDA promotes algal health by killing unwanted marine pathogens; however, its mode of action (MoA) and significance for the survival of an algal–bacterial miniecosystem remains unknown. Using cytological profiling, we herein determine the MoA of TDA and surprisingly find that it acts by a mechanism similar to polyether antibiotics, which are structurally highly divergent. We show that like polyether drugs, TDA collapses the proton motive force by a proton antiport mechanism, in which extracellular protons are exchanged for cytoplasmic cations. The α-carboxy-tropone substructure is ideal for this purpose as the proton can be carried on the carboxyl group, whereas the basicity of the tropylium ion facilitates cation export. Based on similarities to polyether anticancer agents we have further examined TDA’s cytotoxicity and find it to exhibit potent, broad-spectrum anticancer activities. These results highlight the power of MoA-profiling technologies in repurposing old drugs for new targets. In addition, we identify an operon that confers TDA resistance to the producing marine bacteria. Bioinformatic and biochemical analyses of these genes lead to a previously unknown metabolic link between TDA/acid resistance and the γ-glutamyl cycle. The implications of this resistance mechanism in the context of the algal-bacterial symbiosis are discussed.

scholarly journals The Potential of RIP (Ribosome Inactivating Protein) as Biopesticides

Buletin Eboni ◽  
2019 ◽  
Vol 1 (1) ◽  
pp. 33-39
Author(s):  
Tati Suharti ◽  
Dharmawati F Djam’an
Keyword(s):  
Protein Synthesis ◽  
Broad Spectrum ◽  
Plant Pathogen ◽  
Mode Of Action ◽  
Castor Bean ◽  
Insect Pests ◽  
Bitter Melon ◽  
Ribosome Inactivating Protein ◽  
High Potency ◽  
Anti Fungal

RIP (Ribosome Inactivating Protein) produced by plants that can act as a plant defense from pest and disease. This protein is widely used as an anti-fungal, anti-bacterial, anti-virus and anti-insect. Therefore, RIP contained in plants has the potential to be used for environmentally friendly biopesticides. The purpose of this paper is to provide information on RIP derived from plants and its potential as a biopesticide.The mode of action of RIP works is by inhibiting protein synthesis during translating process of pest and plant pathogen. RIP has a broad spectrum so that it can overcome insect pests from various orders and pathogens both fungi, bacteria and viruses. Some types of plants that contain RIP include neem, ginger, turmeric, galangal, castor bean, jatropha, soursop and bitter melon. RP applications can be in the form of oil, essential oils, solutions, flour, ash and simplicia. RIP can be applied to seeds, seeds, plants and post-harvest products. The advantages of using RIP include easily available materials, inexpensive, easy to application and environmentally friendly.The plants contain RP has high potency to commercially developed so in the future, the controlling of pest and disease rely on the plants contain RIP both direct and in the pesticides formulations form. Therefore echo friendly plantation programme can be realized.

scholarly journals Update on diamondback moth (Plutella xylostella) insecticide resistance and the vegetable brassica insecticide management strategy

2012 ◽  
Vol 65 ◽  
pp. 114-119
Author(s):  
G.P. Walker ◽  
S.I. Davis ◽  
F.H. MacDonald ◽  
T.J.B. Herman
Keyword(s):  
Insecticide Resistance ◽  
Plutella Xylostella ◽  
Mode Of Action ◽  
Management Strategy ◽  
Diamondback Moth ◽  
Resistance Management ◽  
Foliar Spray ◽  
Insecticide Resistance Management ◽  
Rotation Strategy ◽  
Vegetable Brassica

The susceptibility of field populations of diamondback moth (DBM) Plutella xylostella to lambdacyhalothrin methamidophos spinosad and indoxacarb collected from the four major brassicagrowing regions has been assessed approximately every 2 years from 1997 to 2008 Recent results indicate that populations from all regions have increased their resistance to lambdacyhalothrin but there is little or no resistance to spinosad and indoxacarb and reduced resistance to methamidophos This mitigation of resistance in DBM is attributed to in particular a decadelong regional adherence by the vegetable industry of rotating spinosad with indoxacarb in a twowindowsperyear rotation strategy The original insecticide resistance management rotation strategy had to be updated to incorporate chlorantraniliprole registered as a foliar spray and recently a mixture of chlorantraniliprole and thiamethoxam as a seedling drench Seedling drenches have been removed from the twowindow strategy used for foliar sprays with drenches now aligned with periods targeting the highest pest pressure allowing mode of action (MoA)free periods and rotation of different MoA insecticides to mitigate any resistance buildup in DBM

scholarly journals Effective Use of Emamectin Benzoate for the Management of Spodoptera frugiperda (J. E. Smith) in Maize

BioAssay ◽  
2021 ◽  
Vol 12 ◽  
pp. ba12001
Author(s):  
Fátima T. Rampelotti-Ferreira ◽  
Leonardo V. Thiesen ◽  
Janaina de N. Corassa ◽  
Adriana Nardon ◽  
Leandro V. dos Santos ◽  
...  
Keyword(s):  
Field Study ◽  
Pest Management ◽  
Spodoptera Frugiperda ◽  
Mode Of Action ◽  
Resistance Management ◽  
Emamectin Benzoate ◽  
Mato Grosso ◽  
Real Risk ◽  
Effective Use ◽  
Selection Of

Emamectin benzoate has been largely used for controling lepidopterans larvae in grains and fiber crops and, therefore, selection of resistant populations to this pesticide is a real risk if ignored the insect resistance management (IRM) strategies. We studied the susceptibility of Spodoptera frugiperda (Smith, 1797) populations in the state of Mato Grosso - Brazil to Emamectin benzoate as well as a field study about Mode of Action rotation including this compound. Low variations in susceptibility (resistance ratios, 1,01-7,31 fold) were detected among the evalueted S. frugiperda populations. The field study reinforced our monitorings outcome that Emamectin Benzoate controls S. frugiperda and its use in IRM in Mato Grosso is practicable. Susceptibility monitoring should be continuous in order to detect possible increases of tolerance rates not only for this pesticide but also for all compounds used for this pest management aiming to apply early mitigation actions.

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