Exemplar Abstract for Mycobacterium avium paratuberculosis (Bergey et al. 1923) Thorel et al. 1990.

2003 ◽  
Author(s):  
Charles Thomas Parker ◽  
Dorothea Taylor ◽  
George M Garrity
Keyword(s):  
Mycobacterium Avium ◽  
Mycobacterium Avium Paratuberculosis

scholarly journals Antibodies Recognizing Mycobacterium avium paratuberculosis Epitopes Cross-React with the Beta-Cell Antigen ZnT8 in Sardinian Type 1 Diabetic Patients

PLoS ONE ◽  
2011 ◽  
Vol 6 (10) ◽  
pp. e26931 ◽  
Author(s):  
Speranza Masala ◽  
Daniela Paccagnini ◽  
Davide Cossu ◽  
Vedran Brezar ◽  
Adolfo Pacifico ◽  
...  
Keyword(s):  
Beta Cell ◽  
Mycobacterium Avium ◽  
Diabetic Patients ◽  
Mycobacterium Avium Paratuberculosis ◽  
Cell Antigen ◽  
Type 1 Diabetic Patients

scholarly journals Mycobacterium avium paratuberculosis infection of calves – The impact of dam infection status

2020 ◽  
Vol 181 ◽  
pp. 104634 ◽  
Author(s):  
S. Patterson ◽  
K. Bond ◽  
M. Green ◽  
S. van Winden ◽  
J. Guitian
Keyword(s):  
Mycobacterium Avium ◽  
Infection Status ◽  
Mycobacterium Avium Paratuberculosis ◽  
The Impact

scholarly journals Notch-1 Signaling Modulates Macrophage Polarization and Immune Defense against Mycobacterium avium paratuberculosis Infection in Inflammatory Diseases

2020 ◽  
Vol 8 (7) ◽  
pp. 1006 ◽  
Author(s):  
Esra’a Keewan ◽  
Saleh A. Naser
Keyword(s):  
Inflammatory Response ◽  
Notch Signaling ◽  
Mycobacterium Avium ◽  
Macrophage Polarization ◽  
Immune Defense ◽  
Notch 1 ◽  
Macrophage Response ◽  
Mycobacterium Avium Paratuberculosis ◽  
Vitro Effect

Despite the extensive research on Notch signaling involvement in inflammation, its specific role in macrophage response in autoimmune disease and defense mechanisms against bacterial infection, such as Mycobacterium avium paratuberculosis (MAP), remains unknown. In this study, we investigated the molecular role of Notch-1 signaling in the macrophage response during MAP infection. In particular, we measured the in vitro effect of MAP on Notch-1 signaling and downstream influence on interleukin (IL)-6 and myeloid cell leukemia sequence-1 (MCL-1) and consequent cellular apoptosis, MAP viability, and macrophage polarization. Overall, the data show significant upregulation in Notch-1, IL-6, and MCL-1 in MAP-infected macrophages, parallel with a decrease in apoptosis and elevated pro-inflammatory response in these infected cells. On the contrary, blocking Notch signaling with γ-secretase inhibitor (DAPT) decreased MAP survival and burden, increased apoptosis, and diminished the pro-inflammatory response. In particular, the treatment of infected macrophages with DAPT shifted macrophage polarization toward M2 anti-inflammatory phenotypic response. The outcome of this study clearly demonstrates the critical role of Notch signaling in macrophage response during infection. We conclude that MAP infection in macrophages activates Notch-1 signaling and downstream influence on IL-6 which hijack MCL-1 dependent inhibition of apoptosis leading to its chronic persistence, and further inflammation. This study supports Notch-1 signaling as a therapeutic target to combat infection in autoimmune diseases such as Crohn’s disease and Rheumatoid Arthritis.

scholarly journals Gastrointestinal: Mycobacterium avium paratuberculosis and Crohn's disease

2005 ◽  
Vol 20 (12) ◽  
pp. 1943-1943 ◽  
Author(s):  
RB Gearry ◽  
JM Aitken ◽  
RL Roberts ◽  
S Ismail ◽  
J Keenan ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Mycobacterium Avium ◽  
Mycobacterium Avium Paratuberculosis

Serological, culture and molecular survey of Mycobacterium avium paratuberculosis in a goat flock in Tuscany

2017 ◽  
Vol 62 (6) ◽  
pp. 471-477 ◽  
Author(s):  
Alessia Galiero ◽  
Barbara Turchi ◽  
Francesca Pedonese ◽  
Roberta Nuvoloni ◽  
Carlo Cantile ◽  
...  
Keyword(s):  
Mycobacterium Avium ◽  
Mycobacterium Avium Paratuberculosis ◽  
Molecular Survey ◽  
Goat Flock

scholarly journals Mycobacterium Avium Paratuberculosis: A Disease Burden on the Dairy Industry

Animals ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1773
Author(s):  
Mary Garvey
Keyword(s):  
Economic Impact ◽  
Mycobacterium Avium ◽  
Dairy Industry ◽  
Latency Period ◽  
Johne's Disease ◽  
Johne’S Disease ◽  
Control Measures ◽  
Dairy Herds ◽  
Infectious Dose ◽  
Mycobacterium Avium Paratuberculosis

Mycobacterium avium paratuberculosis is responsible for paratuberculosis or Johne’s disease in cows, having economic impacts on the dairy industry and a prevalence rate exceeding 50% in dairy herds. The economic burden of Johne’s disease relates to decreased milk production and costs of disease prevention, treatment, and management, while having an economic impact on dairy producers, processors, consumers, and stakeholders of the dairy industry. Determining the true economic impact of the disease is difficult at regional and farm level as symptoms are not evident in subclinically infected animals. At present, the virulence, pathogenicity, persistence, and infectious dose of M. avium paratuberculosis are poorly understood, consequently effective paratuberculosis control measures remain obscure. M. avium paratuberculosis is potentially zoonotic with foodborne transmission a public health risk due to a possible causative link with inflammatory bowel disease in humans. A preventive approach is necessary to reduce the presence of this drug-resistant pathogen in dairy herds and subsequently dairy food. The use of inefficient diagnostic tests coupled with the long latency period of infection results in delayed animal culling and trade of asymptomatic animals, leading to regional transmission and increased disease prevalence. To date, there has been limited success at controlling and treating this terminal endemic disease, leading to significant prevalence rates. This study aims to outline the key factors associated with Johne’s’ disease while outlining its significant impact on the dairy sector.

Radiometric culture of Mycobacterium avium paratuberculosis from the feces of tule elk

1997 ◽  
Vol 33 (3) ◽  
pp. 635-637 ◽  
Author(s):  
W. E. Cook ◽  
T. E. Cornish ◽  
S. Shideler ◽  
B. Lasley ◽  
M. T. Collins
Keyword(s):  
Mycobacterium Avium ◽  
Mycobacterium Avium Paratuberculosis ◽  
Tule Elk
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