Animal Studies: Habitat, Adaptations for Survival, Environmental Factors, and Human Impact—An Interdisciplinary Unit for Grade 4

2014 ◽  
pp. 1-23
Author(s):  
Erin FitzPatrick ◽  
Katie Schrodt
Keyword(s):  
Environmental Factors ◽  
Human Impact ◽  
Animal Studies

scholarly journals Epigenetic Approach to PTSD: In the Aspects of Rat Models

2021 ◽  
Author(s):  
Asli Aykac ◽  
Rasime Kalkan
Keyword(s):  
Risk Factors ◽  
Environmental Factors ◽  
Animal Studies ◽  
Stress Disorder ◽  
Biological Response ◽  
Traumatic Experiences ◽  
Biochemical Processes ◽  
Life Threatening ◽  
Shed Light

AbstractPosttraumatic stress disorder (PTSD) is a stress-related mental disorder and develops after exposure to life-threatening traumatic experiences. The risk factors of PTSD included genetic factors; alterations in hypothalamic–pituitary–adrenal (HPA) axis; neurotrophic, serotonergic, dopaminergic, and catecholaminergic systems; and a variety of environmental factors, such as war, accident, natural disaster, pandemic, physical, or sexual abuse, that cause stress or trauma in individuals. To be able to understand the molecular background of PTSD, rodent animal models are widely used by researchers. When looking for a solution for PTSD, it is important to consider preexisting genetic risk factors and physiological, molecular, and biochemical processes caused by trauma that may cause susceptibility to this disorder. In studies, it is reported that epigenetic mechanisms play important roles in the biological response affected by environmental factors, as well as the task of programming cell identity. In this article, we provided an overview of the role of epigenetic modifications in understanding the biology of PTSD. We also summarized the data from animal studies and their importance during the investigation of PTSD. This study shed light on the epigenetic background of stress and PTSD.

scholarly journals Environmental factors acting during development to influence MS risk: insights from animal studies

2013 ◽  
Vol 19 (13) ◽  
pp. 1684-1689 ◽  
Author(s):  
Dimitry N Krementsov ◽  
Cory Teuscher
Keyword(s):  
Environmental Factors ◽  
Animal Studies ◽  
Molecular Mechanisms ◽  
Demyelinating Disease ◽  
Disease Risk ◽  
Clinical Intervention ◽  
Population Level ◽  
Epidemiological Data ◽  
Developmental Exposure ◽  
The Central Nervous System

Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system with an increasing incidence in females. Epidemiological data strongly implicate environmental factors acting at the population level during gestation, childhood and adulthood in the increasing incidence of MS. Several such factors are implicated in disease risk, but their causality remains unproven, while other factors remain unknown. An understanding of the risk factors acting during development is particularly limited. Animal studies could potentially bridge the gap between observational epidemiology and clinical intervention, providing not only direct evidence of causality for a given environmental agent, but also an opportunity to dissect the underlying molecular mechanisms. Given a rodent’s short gestational and developmental period, the effects of developmental exposure can also be readily addressed. Nonetheless, studies in this area so far are few. In this review, we summarize the insights gleaned from studies that test environmental influences in animal models of MS, with a particular focus on gestational and early life exposures.

scholarly journals Pattern of Urban Flora in Intra-City Railway Habitats (Alexandria, Egypt): A Conservation Perspective

Biology ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 698
Author(s):  
Selim Z. Heneidy ◽  
Marwa W. A. Halmy ◽  
Soliman M. Toto ◽  
Sania K. Hamouda ◽  
Amal M. Fakhry ◽  
...  
Keyword(s):  
Invasive Species ◽  
Environmental Factors ◽  
Human Impact ◽  
Native Species ◽  
Climatic Factors ◽  
Detrended Correspondence Analysis ◽  
Floristic Composition ◽  
Conservation Action ◽  
Urban Flora ◽  
Rare And Endangered Species

Intra-city railway areas are deemed large greenspaces and are believed to be key in enhancing the diversity and dynamics of urban flora. In the current study, the floristic composition and diversity along intra-city railway and tram tracks in Alexandria were surveyed. The floristic composition of the plant communities in relation to environmental factors, ecological indicators, and level of human impact was analyzed using multivariate analysis (two-way indicator species analysis (TWINSPAN) for classification and detrended correspondence analysis (DECORANA) for ordination. The multivariate ordination techniques (CCA) revealed differences in the environmental factors and climatic factors influencing the floristic composition of the railway and tram track habitats. Tram tracks suffered higher human impact while maintaining higher vitality and cover compared to train tracks. Species recorded were mainly therophytes, followed by phanerophytes and hemicryptophytes dominated by native species; however, invasive species’ contribution was higher compared to surrounding regions. The number of invasive species was greater in railway areas compared to tram track areas (19 and 15, respectively). The occurrence of two endemic species (Sinapis allionii and Sonchus macrocarpus) with limited national distribution highlights the importance of these habitats as valuable refuge areas for rare and endangered species worthy of conservation action.

The effects of rock climbing on the vegetation of three Minnesota cliff systems

1998 ◽  
Vol 76 (12) ◽  
pp. 1981-1990 ◽  
Author(s):  
Michael A Farris
Keyword(s):  
Environmental Factors ◽  
Human Impact ◽  
Human Disturbance ◽  
Vegetation Structure ◽  
Plant Cover ◽  
Technical Difficulty ◽  
Rock Climbing ◽  
Total Plant ◽  
Human Use ◽  
Careful Assessment

I quantified the distribution and abundance of major plant taxa on three distinct cliff systems in Minnesota and examined the effects of recreational rock climbing on that vegetation. The three cliff systems differed significantly in the amount and type of vegetation present in undisturbed plots. Frequencies of most taxa were lower in climbed areas, although the differences were generally not significant. Total plant cover was significantly lower in climbed plots at all three locations. Fragile forms, such as umbilicate and fruticose lichens, were especially sensitive to human disturbance. The microtopography of the rock substrate had a significant impact on both the amount of vegetation present and the use of a cliff area by climbers. Cracks in the rock were significantly more common in climbed areas while ledges were less common. Microtopography also varied with the technical difficulty of the climbing route. While human impact decreased vegetation frequency and cover on these cliffs, identification of causal links between human disturbance and vegetation structure must include a careful assessment of the geological and environmental factors that strongly influence both human use and vegetation dynamics.Key words: cliff, lichen, rock climbing, vegetation, Minnesota, human disturbance.

Reductionist thinking and animal models in neuropsychiatric research

2019 ◽  
Vol 42 ◽  
Author(s):  
Nicole M. Baran
Keyword(s):  
Animal Models ◽  
Mental Disorders ◽  
Environmental Factors ◽  
Neuropsychiatric Disorders ◽  
Model Organisms ◽  
Developmental Genetic ◽  
Term Study ◽  
Genetic And Environmental Factors ◽  
Mechanisms Of Plasticity

AbstractReductionist thinking in neuroscience is manifest in the widespread use of animal models of neuropsychiatric disorders. Broader investigations of diverse behaviors in non-model organisms and longer-term study of the mechanisms of plasticity will yield fundamental insights into the neurobiological, developmental, genetic, and environmental factors contributing to the “massively multifactorial system networks” which go awry in mental disorders.

Decellularized bone extracellular matrix in skeletal tissue engineering

2020 ◽  
Vol 48 (3) ◽  
pp. 755-764
Author(s):  
Benjamin B. Rothrauff ◽  
Rocky S. Tuan
Keyword(s):  
Tissue Engineering ◽  
Bone Regeneration ◽  
Tissue Regeneration ◽  
Animal Studies ◽  
Tumor Resection ◽  
Regenerative Capacity ◽  
Skeletal Tissue ◽  
Large Bone

Bone possesses an intrinsic regenerative capacity, which can be compromised by aging, disease, trauma, and iatrogenesis (e.g. tumor resection, pharmacological). At present, autografts and allografts are the principal biological treatments available to replace large bone segments, but both entail several limitations that reduce wider use and consistent success. The use of decellularized extracellular matrices (ECM), often derived from xenogeneic sources, has been shown to favorably influence the immune response to injury and promote site-appropriate tissue regeneration. Decellularized bone ECM (dbECM), utilized in several forms — whole organ, particles, hydrogels — has shown promise in both in vitro and in vivo animal studies to promote osteogenic differentiation of stem/progenitor cells and enhance bone regeneration. However, dbECM has yet to be investigated in clinical studies, which are needed to determine the relative efficacy of this emerging biomaterial as compared with established treatments. This mini-review highlights the recent exploration of dbECM as a biomaterial for skeletal tissue engineering and considers modifications on its future use to more consistently promote bone regeneration.

The dual nature of obesity in metabolic programming: quantity versus quality of adipose tissue

2020 ◽  
Vol 134 (18) ◽  
pp. 2447-2451
Author(s):  
Anissa Viveiros ◽  
Gavin Y. Oudit
Keyword(s):  
Adipose Tissue ◽  
Environmental Factors ◽  
Maternal Obesity ◽  
Metabolic Programming ◽  
Dual Nature ◽  
Prevalence Of Obesity ◽  
Adipose Tissue Volume ◽  
Males And Females ◽  
Metabolically Healthy

Abstract The global prevalence of obesity has been rising at an alarming rate, accompanied by an increase in both childhood and maternal obesity. The concept of metabolic programming is highly topical, and in this context, describes a predisposition of offspring of obese mothers to the development of obesity independent of environmental factors. Research published in this issue of Clinical Science conducted by Litzenburger and colleagues (Clin. Sci. (Lond.) (2020) 134, 921–939) have identified sex-dependent differences in metabolic programming and identify putative signaling pathways involved in the differential phenotype of adipose tissue between males and females. Delineating the distinction between metabolically healthy and unhealthy obesity is a topic of emerging interest, and the precise nature of adipocytes are key to pathogenesis, independent of adipose tissue volume.

Shared Responsibilities for Full Participation in Society: Planning Further Integration of the ICF Into AAC

2016 ◽  
Vol 1 (12) ◽  
pp. 83-93 ◽  
Author(s):  
Mary Blake Huer ◽  
Travis T. Threats
Keyword(s):  
Environmental Factors ◽  
Augmentative And Alternative Communication ◽  
Functional Limitations ◽  
Community Support ◽  
World Health ◽  
International Classification Of Functioning ◽  
Personal Factors ◽  
Social Service Agencies ◽  
Persons With Disabilities ◽  
Full Participation

The World Health Organization's (WHO's) 2001 International Classification of Functioning Disability and Health (ICF) has as one of its central tenets the full inclusion of persons with disabilities in society. It acknowledges the need for medical and rehabilitation intervention in its biopscychosocial framework. However, the WHO realizes that society must do its part to facilitate this full participation and empowerment. Persons with complex communication needs (PWCCN) often need augmentative and alternative communication (AAC) in order to express themselves. However, in order to access and successfully use AAC, PWCCN need access to the necessary AAC devices and services, as well as a willing society to interact with them as full contributing members of society. The factors outside of a person's specific physical and/or cognitive functional limitations are addressed in the ICF via the Personal and Environmental Factors. Personal Factors include the individual's personality traits, lifestyle, experiences, social/educational/professional background, race, gender, and age. Environmental Factors include community support systems, social service agencies, governments, social networks, and those persons that interact with the PWCCN. This article addresses the sociopolitical influences on PWCCN and their functioning from a human rights perspective. The necessary introspective role of speech-language pathologists in this process is explored.

377: Distribution of Smoking, Water Resource and Other Environmental Factors in Patients Affected by Superficial Bladder Cancer

2004 ◽  
Vol 171 (4S) ◽  
pp. 99-99
Author(s):  
Vincenzo Serretta ◽  
Vincenzo Altieri ◽  
Giuseppe Morgia ◽  
Rosalinda Allegro ◽  
Alessandra Di Lallo ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Environmental Factors ◽  
Water Resource ◽  
Superficial Bladder Cancer
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