scholarly journals HSP90 Inhibitor SNX5422/ 2112 Targets the Dysregulated Signal and Transcription Factor Network and Malignant Phenotype of Head and Neck Squamous Cell Carcinoma

2013 ◽  
Vol 6 (4) ◽  
pp. 429-IN5 ◽  
Author(s):  
Jay A. Friedman ◽  
Stephanie C. Wise ◽  
Michael Hu ◽  
Chris Gouveia ◽  
Robert Vander Broek ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Transcription Factor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Hsp90 Inhibitor ◽  
Neck Squamous Cell Carcinoma ◽  
Malignant Phenotype ◽  
Transcription Factor Network

Abstract 3409: Transcription factor signature of head and neck squamous cell carcinoma

2014 ◽  
Author(s):  
Daria A. Gaykalova ◽  
Judi Manola ◽  
Hiroyuki Ozawa ◽  
Kathryn Morton ◽  
Justin Bishop ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Transcription Factor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma

scholarly journals Brusatol, a Nrf2 Inhibitor Targets STAT3 Signaling Cascade in Head and Neck Squamous Cell Carcinoma

Biomolecules ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 550 ◽  
Author(s):  
Jong Hyun Lee ◽  
Shobith Rangappa ◽  
Chakrabhavi Dhananjaya Mohan ◽  
Basappa ◽  
Gautam Sethi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Transcription Factor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Signaling Pathway ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Parp Cleavage ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway

STAT3 is a latent transcription factor that plays a vital role in the transmission of extracellular signal from receptors to the nucleus. It has been regarded as a master transcription factor due to its role in the regulation of a broad spectrum of genes, which can contribute to oncogenesis. Persistent activation of STAT3 and deregulation of its signaling has been observed in various human cancers including head and neck squamous cell carcinoma (HNSCC). In the present work, we identified brusatol (BT) as a potential blocker of STAT3 signaling pathway in diverse HNSCC cells. The data from the cell-based experiments suggested that BT-induced cytotoxicity and abrogated the activation of STAT3 and that of upstream kinases such as JAK1, JAK2, and Src. It reduced the levels of nuclear STAT3 and its DNA binding ability. BT treatment increased annexin-V-positive cells, promoted procaspase-3 and PARP cleavage, and downregulated the mRNA and protein expression of diverse proteins (Bcl-2, Bcl-xl, survivin) in HNSCC cells. Taken together, brusatol can function as a promising inhibitor targeting STAT3 signaling pathway in HNSCC.

scholarly journals The transcription factor FOXM1 regulates the balance between proliferation and aberrant differentiation in head and neck squamous cell carcinoma

2019 ◽  
Vol 250 (1) ◽  
pp. 107-119
Author(s):  
Vincent Roh ◽  
Agnès Hiou‐Feige ◽  
Vinko Misetic ◽  
Jean‐Paul Rivals ◽  
Jana Sponarova ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Transcription Factor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma

DHQZ-17, a potent inhibitor of the transcription factor HNF4A, suppresses tumorigenicity of head and neck squamous cell carcinoma in vivo

2017 ◽  
Vol 233 (3) ◽  
pp. 2613-2628 ◽  
Author(s):  
Shilpa Tentu ◽  
Kumarswamyreddy Nandarapu ◽  
Prakash Muthuraj ◽  
Kesavan Venkitasamy ◽  
Ganesh Venkatraman ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Transcription Factor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Potent Inhibitor ◽  
Neck Squamous Cell Carcinoma

scholarly journals NF-κB and stat3 transcription factor signatures differentiate HPV-positive and HPV-negative head and neck squamous cell carcinoma

2015 ◽  
Vol 137 (8) ◽  
pp. 1879-1889 ◽  
Author(s):  
Daria A. Gaykalova ◽  
Judith B. Manola ◽  
Hiroyuki Ozawa ◽  
Veronika Zizkova ◽  
Kathryn Morton ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Transcription Factor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Stat3 Transcription Factor

scholarly journals BIIB021, a novel HSP90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy

2009 ◽  
pp. NA-NA ◽  
Author(s):  
Xiaoying Yin ◽  
Hong Zhang ◽  
Karen Lundgren ◽  
Lynn Wilson ◽  
Francis Burrows ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Hsp90 Inhibitor ◽  
Neck Squamous Cell Carcinoma
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