scholarly journals Silibinin Suppresses Growth of Human Colorectal Carcinoma SW480 Cells in Culture and Xenograft through Down-regulation of β-Catenin-Dependent Signaling

Neoplasia ◽  
2010 ◽  
Vol 12 (5) ◽  
pp. 415-424 ◽  
Author(s):  
Manjinder Kaur ◽  
Balaiya Velmurugan ◽  
Alpna Tyagi ◽  
Chapla Agarwal ◽  
Rana P. Singh ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Down Regulation ◽  
Cells In Culture ◽  
Sw480 Cells ◽  
Human Colorectal Carcinoma

scholarly journals Silibinin suppresses growth and induces apoptotic death of human colorectal carcinoma LoVo cells in culture and tumor xenograft

2009 ◽  
Vol 8 (8) ◽  
pp. 2366-2374 ◽  
Author(s):  
Manjinder Kaur ◽  
Balaiya Velmurugan ◽  
Alpna Tyagi ◽  
Gagan Deep ◽  
Suchitra Katiyar ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Tumor Xenograft ◽  
Cells In Culture ◽  
Apoptotic Death ◽  
Lovo Cells ◽  
Human Colorectal Carcinoma

LYG-202 inhibits the proliferation of human colorectal carcinoma HCT-116 cells through induction of G1/S cell cycle arrest and apoptosis via p53 and p21WAF1/Cip1 expression

2011 ◽  
Vol 89 (3) ◽  
pp. 287-298 ◽  
Author(s):  
Wei Liu ◽  
Qinsheng Dai ◽  
Na Lu ◽  
Libin Wei ◽  
Jun Ha ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colorectal Carcinoma ◽  
Cell Cycle Arrest ◽  
Caspase 3 ◽  
Down Regulation ◽  
Transfected Cells ◽  
Cycle Arrest ◽  
Hct 116 ◽  
Human Colorectal Carcinoma ◽  
Hct 116 Cells

We recently established that LYG-202, a new flavonoid with a piperazine substitution, exerts an anti-tumor effect in vivo and in vitro. In the present study, we demonstrate that LYG-202 induces G1/S phase arrest and apoptosis in human colorectal carcinoma HCT-116 cells. Data showed that the blockade of the cell cycle was associated with increased p21WAF1/Cip1 and Rb levels and reduced expression of cyclin D1, cyclin E, and CDK4. Moreover, PARP cleavage, activation of caspase-3, caspase-8, and caspase-9, and an increased ratio of Bax/Bcl-2 were detected in LYG-202-induced apoptosis. Additionally, activation of p53 resulted in the up-regulation of its downstream targets PUMA and p21WAF1/Cip1, as well as the down-regulation of its negative regulator MDM2, suggesting that the p53 pathway may play a crucial role in LYG-202-induced cell cycle arrest and apoptosis. Furthermore, siRNA knockdown of p53 attenuated the G1 cell cycle arrest and apoptosis induced by LYG-202, as the effects of LYG-202 on up-regulation of p21WAF1/Cip1 and down-regulation of Bcl-2 and pro-caspase-3 were partly inhibited in p53 siRNA transfected cells compared with control siRNA transfected cells. Collectively, these data indicate that LYG-202 exerts its anti-tumor potency by activating the p53–p21 pathway for G1/S cell cycle arrest and apoptosis in colorectal cancer cells.

Andrographolide could inhibit human colorectal carcinoma Lovo cells migration and invasion via down-regulation of MMP-7 expression

2009 ◽  
Vol 180 (3) ◽  
pp. 344-352 ◽  
Author(s):  
Ming-Der Shi ◽  
Hui-Hsuan Lin ◽  
Tai-An Chiang ◽  
Li-Yu Tsai ◽  
Shu-Mei Tsai ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Migration And Invasion ◽  
Down Regulation ◽  
Lovo Cells ◽  
Human Colorectal Carcinoma

Fatty Acid Profile and In Vitro Anticancer Activity of Two Marine Sponge- Associated Bacteria

2020 ◽  
Vol 16 (9) ◽  
pp. 1273-1280
Author(s):  
Giuseppina Tommonaro ◽  
Ali M. El-Hagrassi ◽  
Walid Fayad ◽  
Carmine Iodice ◽  
Kamel H. Shaker ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Colorectal Carcinoma ◽  
Cell Line ◽  
Marine Sponge ◽  
Hct116 Cell ◽  
Associated Bacteria ◽  
Sponge Associated Bacteria ◽  
Human Colorectal Carcinoma

Background: Colorectal cancer represents one of the prominent causes of mortality worldwide in men and women. The objective of this study was to search for new potential anticancer compounds, both in prevention and treatment of colorectal cancer. The anticancer potential of marine bacterial extracts against Human colorectal carcinoma cell line (HCT116) was evaluated as well as the partial identification of bioactive metabolites. Methods: All bacterial extracts were tested for their cytotoxicity against HCT116 cell line by means of MTT assay. The highly cytotoxic dichloromethane extracts of marine sponge-associated bacteria Vibrio sp. and Bacillus sp. were analyzed by GC-MS. Results: Two fractions, Vib3 and Bac3, exhibited a very interesting cytotoxicity against human colorectal carcinoma (HCT116) cell line, with a percentage of cytotoxicity of 96.04 % and 29.48 %, respectively. Discussion: The GC-MS analysis revealed the presence of two major fatty acids, palmitic and oleic acids, in Vib3 fraction and fatty acid esters and phenolic compounds in Bac3 fraction. Conclusion: Based on previous literature, it may be hypothesized that the anticancer activity of bacterial extracts could be, at least partially, to the fatty acids fraction.

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