scholarly journals Clinical Evaluation of M30 and M65 ELISA Cell Death Assays as Circulating Biomarkers in a Drug-Sensitive Tumor, Testicular Cancer

Neoplasia ◽  
2008 ◽  
Vol 10 (10) ◽  
pp. 1041-1048 ◽  
Author(s):  
Esther C. de Haas ◽  
Alessandra di Pietro ◽  
Kathryn L. Simpson ◽  
Coby Meijer ◽  
Albert J.H. Suurmeijer ◽  
...  
Keyword(s):  
Cell Death ◽  
Testicular Cancer ◽  
Clinical Evaluation ◽  
Circulating Biomarkers

Determination of cell death modes using circulating biomarkers

2011 ◽  
Vol 32 (2) ◽  
pp. 347-348
Author(s):  
Stig Linder ◽  
Richard Herrmann
Keyword(s):  
Cell Death ◽  
Circulating Biomarkers

scholarly journals Optimisation of circulating biomarkers of cell death for routine clinical use

2008 ◽  
Vol 19 (5) ◽  
pp. 990-995 ◽  
Author(s):  
A. Greystoke ◽  
J. Cummings ◽  
T. Ward ◽  
K. Simpson ◽  
A. Renehan ◽  
...  
Keyword(s):  
Cell Death ◽  
Clinical Use ◽  
Circulating Biomarkers

Elevated Serum Levels of Cell Death Circulating Biomarkers, M30 and M65, In Patients with β-Thalassemia Major

Hemoglobin ◽  
2013 ◽  
Vol 37 (4) ◽  
pp. 404-410
Author(s):  
Nafiseh Esmaeil ◽  
Behjat Moayedi ◽  
Marjan Gharagozloo ◽  
Mohamad Reza Maracy
Keyword(s):  
Cell Death ◽  
Elevated Serum ◽  
Serum Levels ◽  
Thalassemia Major ◽  
Circulating Biomarkers

scholarly journals Elevated levels of circulating biomarkers of cell death (nucleosomes) in the patients with plaque psoriasis treated with the Goeckerman regimen

2014 ◽  
Vol 115 (04) ◽  
pp. 229-232 ◽  
Author(s):  
D. Ranna ◽  
C. Andrys ◽  
J. Krejsek ◽  
K. Hamakova ◽  
J. Kremlacek ◽  
...  
Keyword(s):  
Cell Death ◽  
Plaque Psoriasis ◽  
Circulating Biomarkers ◽  
Goeckerman Regimen

scholarly journals PNU-74654 Suppresses TNFR1/IKB Alpha/p65 Signaling and Induces Cell Death in Testicular Cancer

2022 ◽  
Vol 44 (1) ◽  
pp. 222-232
Author(s):  
Wen-Jung Chen ◽  
Wen-Wei Sung ◽  
Chia-Ying Yu ◽  
Yu-Ze Luan ◽  
Ya-Chuan Chang ◽  
...  
Keyword(s):  
Cell Death ◽  
Testicular Cancer ◽  
Cell Viability ◽  
Cell Lines ◽  
Cancer Progression ◽  
Treatment Strategies ◽  
Annexin V ◽  
Western Blots ◽  
Execution Phase ◽  
Induced Apoptosis

Testicular cancer (TC) is a rare malignancy worldwide and is the most common malignancy in males aged 15–44 years. The Wnt/β-catenin signaling pathway mediates numerous essential cellular functions and has potentially important effects on tumorigenesis and cancer progression. The search for drugs to inhibit this pathway has identified a small molecule, PNU-74654, as an inhibitor of the β-catenin/TCF4 interaction. We evaluated the therapeutic role of PNU-74654 in two TC cell lines, NCCIT and NTERA2, by measuring cell viability, cell cycle transition and cell death. Potential pathways were evaluated by protein arrays and Western blots. PNU-74654 decreased cell viability and induced apoptosis of TC cells, with significant increases in the sub G1, Hoechst-stained, Annexin V-PI-positive rates. PNU-74654 treatment of both TC cell lines inhibited the TNFR1/IKB alpha/p65 pathway and the execution phase of apoptosis. Our findings demonstrate that PNU-74654 can induce apoptosis in TC cells through mechanisms involving the execution phase of apoptosis and inhibition of TNFR1/IKB alpha/p65 signaling. Therefore, small molecules such as PNU-74654 may identify potential new treatment strategies for TC.

scholarly journals CLINICAL EVALUATION ON DIFFERENTIAL QUANTITATION OF HUMAN CHORIONIC GONADOTROPIN IN TESTICULAR CANCER

1990 ◽  
Vol 81 (3) ◽  
pp. 408-413
Author(s):  
Kaoru Nakamura ◽  
Nobuhiro Deguchi ◽  
Masamichi Hagiwara ◽  
Takashi Nakanoma ◽  
Jun-ichi Hata ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Clinical Evaluation ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin

scholarly journals Optimization of Circulating Biomarkers of Obatoclax-Induced Cell Death in Patients with Small Cell Lung Cancer

Neoplasia ◽  
2011 ◽  
Vol 13 (4) ◽  
pp. 339-347 ◽  
Author(s):  
Emma J. Dean ◽  
Jeff Cummings ◽  
Anne Roulston ◽  
Mark Berger ◽  
Malcolm Ranson ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Death ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Circulating Biomarkers ◽  
Small Cell Lung
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