scholarly journals HLA-A2–Restricted Cytotoxic T Lymphocyte Epitopes from Human Heparanase as Novel Targets for Broad-Spectrum Tumor Immunotherapy

Neoplasia ◽  
2008 ◽  
Vol 10 (9) ◽  
pp. 977-986 ◽  
Author(s):  
Ting Chen ◽  
Xu-Dong Tang ◽  
Yin Wan ◽  
Ling Chen ◽  
Song-Tao Yu ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Broad Spectrum ◽  
Cytotoxic T Lymphocyte ◽  
Tumor Immunotherapy ◽  
Novel Targets

scholarly journals HLA-A2-restricted Cytotoxic T Lymphocyte Epitopes from Human Hepsin as Novel Targets for Prostate Cancer Immunotherapy

2013 ◽  
Vol 78 (3) ◽  
pp. 248-257 ◽  
Author(s):  
J. Guo ◽  
G. Li ◽  
J. Tang ◽  
X.-B. Cao ◽  
Q.-Y. Zhou ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Immunotherapy ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Novel Targets

scholarly journals Identification of Two Novel HLA-A∗0201-Restricted CTL Epitopes Derived from MAGE-A4

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Zheng-Cai Jia ◽  
Bing Ni ◽  
Ze-Min Huang ◽  
Yi Tian ◽  
Jun Tang ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Tumor Immunotherapy ◽  
Target Cells ◽  
Ctl Epitopes ◽  
Normal Tissues ◽  
Specific Ctls ◽  
Ct Antigens ◽  
Cancer Testis

MAGE-A antigens belong to cancer/testis (CT) antigens that are expressed in tumors but not in normal tissues except testis and placenta. MAGE-A antigens and their epitope peptides have been used in tumor immunotherapy trials. MAGE-A4 antigen is extensively expressed in various histological types of tumors, so it represents an attractive target for tumor immunotherapy. In this study, we predicted HLA-A∗0201-restricted cytotoxic T lymphocyte (CTL) epitopes of MAGE-A4, followed by peptide/HLA-A∗0201 affinity and complex stability assays. Of selected four peptides (designated P1, P2, P3, and P4), P1 (MAGE-A4286-294, KVLEHVVRV) and P3 (MAGE-A4272-280, FLWGPRALA) could elicit peptide-specific CTLs bothin vitrofrom HLA-A∗0201-positive PBMCs and in HLA-A∗0201/Kbtransgenic mice. And the induced CTLs could lyse target cells in an HLA-A∗0201-restricted fashion, demonstrating that the two peptides are HLA-A∗0201-restricted CTL epitopes and could serve as targets for therapeutic antitumoral vaccination.

scholarly journals HER-2/neu and hTERT Cryptic Epitopes as Novel Targets for Broad Spectrum Tumor Immunotherapy

2002 ◽  
Vol 168 (11) ◽  
pp. 5900-5906 ◽  
Author(s):  
Antonio Scardino ◽  
David-Alexandre Gross ◽  
Pedro Alves ◽  
Joachim L. Schultze ◽  
Stéphanie Graff-Dubois ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Tumor Immunotherapy ◽  
Her 2 ◽  
Novel Targets ◽  
Cryptic Epitopes
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